4 Years Experience in Rheumatology with Tiaprofenic Acid

2015 ◽  
pp. 27-39
Author(s):  
Gabor Katona Salgo
Keyword(s):  
Tiaprofenic Acid

Tiaprofenic acid

1994 ◽  
Vol &NA; (492) ◽  
pp. 12
Author(s):  
&NA;
Keyword(s):  
Tiaprofenic Acid

scholarly journals Thiophene-Based Compounds with Potential Anti-Inflammatory Activity

2021 ◽  
Vol 14 (7) ◽  
pp. 692
Author(s):  
Ryldene Marques Duarte da Cruz ◽  
Francisco Jaime Bezerra Mendonça-Junior ◽  
Natália Barbosa de Mélo ◽  
Luciana Scotti ◽  
Rodrigo Santos Aquino de Araújo ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Structural Characteristics ◽  
Tiaprofenic Acid ◽  
Inflammatory Activity ◽  
Drug Candidates ◽  
Biological Target ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Privileged Structures

Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical treatments, despite their severe side effects and their exclusive action in improving symptoms, without effectively promoting the cure. However, recent advances in the fields of pharmacology, medicinal chemistry, and chemoinformatics have provided valuable information and opportunities for development of new anti-inflammatory drug candidates. For drug design and discovery, thiophene derivatives are privileged structures. Thiophene-based compounds, like the commercial drugs Tinoridine and Tiaprofenic acid, are known for their anti-inflammatory properties. The present review provides an update on the role of thiophene-based derivatives in inflammation. Studies on mechanisms of action, interactions with receptors (especially against cyclooxygenase (COX) and lipoxygenase (LOX)), and structure-activity relationships are also presented and discussed. The results demonstrate the importance of thiophene-based compounds as privileged structures for the design and discovery of novel anti-inflammatory agents. The studies reveal important structural characteristics. The presence of carboxylic acids, esters, amines, and amides, as well as methyl and methoxy groups, has been frequently described, and highlights the importance of these groups for anti-inflammatory activity and biological target recognition, especially for inhibition of COX and LOX enzymes.

scholarly journals Effect of tiaprofenic acid on abnormal sensation in the throat.

1989 ◽  
Vol 82 (10) ◽  
pp. 1497-1506
Author(s):  
Mikikazu Yamagiwa ◽  
Masahiko Kubo ◽  
Teruhiko Harada ◽  
Hiroyuki Yamada ◽  
Yasuo Sakakura
Keyword(s):  
Tiaprofenic Acid

scholarly journals Tiaprofenic acid and cystitis

BMJ ◽  
1994 ◽  
Vol 309 (6954) ◽  
pp. 552-553 ◽  
Author(s):  
D N Bateman
Keyword(s):  
Tiaprofenic Acid

HPLC ANALYSIS OF TIAPROFENIC ACID IN THE SAMPLES OF WHOLE BLOOD USING L-L AND S-L EXTRACTIONS

2000 ◽  
Vol 23 (20) ◽  
pp. 3191-3201 ◽  
Author(s):  
J. Sochor ◽  
J. Klimeš ◽  
J. Sedláček ◽  
B. Somolíková ◽  
D. Slovenčík
Keyword(s):  
Whole Blood ◽  
Hplc Analysis ◽  
Tiaprofenic Acid

Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

1994 ◽  
Vol 22 (2) ◽  
pp. 100-106 ◽  
Author(s):  
G Hasçelik ◽  
B ŞLener ◽  
Z Hasçelik
Keyword(s):  
Acetylsalicylic Acid ◽  
Polymorphonuclear Leukocyte ◽  
Polymorphonuclear Leukocytes ◽  
Diclofenac Sodium ◽  
Tiaprofenic Acid ◽  
Boyden Chamber ◽  
Random Migration ◽  
Leukocyte Chemotaxis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The effects of piroxicam, tenoxicam, diclofenac sodium, acetylsalicylic acid and tiaprofenic acid on the chemotaxis and random migration of human polymorphonuclear leukocytes were investigated, using zymosan-activated serum as chemo-attractant, with a modified Boyden chamber technique. All five compounds significantly reduced chemotaxis. The random migration of polymorphonuclear leukocytes was inhibited by piroxicam, diclofenac sodium and tiaprofenic acid but not by tenoxicam or acetylsalicylic acid. The inhibitory effect of these non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte chemotaxis and on random migration was generally dose-dependent. The results suggest that the drugs studied may have a direct effect on polymorphonuclear leukocyte chemotaxis and that this activity may contribute to their anti-inflammatory properties.

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