Intercorrelations between Different Computer-Based Measures of the EEG Alpha Amplitude and Its Variability over Time and Their Validity in Differentiating Healthy Volunteers from Depressed Patients1

2015 ◽  
pp. 172-181 ◽  
Author(s):  
L. von Knorring ◽  
C. Perris ◽  
L. Goldstein ◽  
D. Kemali ◽  
K. Monakhov ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Computer Based ◽  
Eeg Alpha ◽  
Over Time

scholarly journals Using Redox Potential as a Feasible Marker for Banked Blood Quality and the State of Oxidative Stress in Stored Red Blood Cells

2020 ◽  
Author(s):  
Rodney C Daniels ◽  
Hyesun Jun ◽  
Robertson D Davenport ◽  
Maryanne M Collinson ◽  
Kevin R Ward
Keyword(s):  
Oxidative Stress ◽  
Redox Potential ◽  
Red Blood Cells ◽  
Healthy Volunteers ◽  
Blood Cells ◽  
Storage Time ◽  
Cell Function ◽  
Venous Blood ◽  
Functional Changes ◽  
Over Time

Abstract Background Stored Red Blood Cells (RBCs) may undergo oxidative stress over time, with functional changes affecting critical tasks such as oxygen delivery. Central to these changes are oxidation-reduction (redox) reactions and the redox potential (RP) that must be maintained for proper cell function. RP imbalance can lead to oxidative stress that may contribute to storage lesions and transfusion-related morbidities. Direct measures of RP may allow for evaluation of erythrocyte quality and enable corrections of RP prior to transfusion. Methods Multiple random RBC segments were tested, ranging in age from 5 to 40 days at 5 day intervals. RP was recorded by measuring open circuit potential of RBCs using novel nanoporous gold electrodes with Ag/AgCl reference. RP measures were also performed on peripheral venous blood samples from 10 healthy volunteers. RP measures were compared between groups of aged RBCs, and with volunteer blood. Results Stored RBCs show time-dependent increases in RP. There were significant differences in Day 5 RP compared to all other groups (p≤0.005), Day 10-15 vs ages ≥ Day 20 (p≤0.025), Day 20-25 vs Day 40 (p=0.039), and all groups compared to healthy volunteers. RP became more positive over time suggesting ongoing oxidation as RBCs age. However, storage time alone does not predict the ultimate RP value measured from a given unit.Conclusions There are significant differences in RP between freshly stored RBCs and all others, with RP becoming more positive over time. However, storage time alone does not predict RP, indicating RP screening may be important independent of storage time and may serve as a marker of RBC quality and state of oxidative stress. RP measurements may also provide a target by which to restore RP balance in aged pRBCs, improving their clinical effectiveness while reducing associated morbidities.

scholarly journals The Effect of Hyperinsulinaemic Euglycaemia on Myocardial Blood Flow Reserve in Healthy Volunteers Over Time

2016 ◽  
Vol 25 ◽  
pp. S278
Author(s):  
M. Nam ◽  
T. Stanton ◽  
A. Russell ◽  
I. Hickman ◽  
C. Askew ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Healthy Volunteers ◽  
Flow Reserve ◽  
Myocardial Blood Flow Reserve ◽  
Over Time

scholarly journals Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

2001 ◽  
Vol 52 (5) ◽  
pp. 601-604 ◽  
Author(s):  
T. Simon ◽  
L. Becquemont ◽  
B. Hamon ◽  
E. Nouyrigat ◽  
Y. Chodjania ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Healthy Volunteers ◽  
Cytochrome P450 1A2 ◽  
Over Time

scholarly journals Characteristics of exhaled particle production in healthy volunteers: possible implications for infectious disease transmission

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 14 ◽  
Author(s):  
Fatima Wurie ◽  
Olivier Le Polain de Waroux ◽  
Matthew Brande ◽  
Wesley DeHaan ◽  
Katherine Holdgate ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Respiratory Infection ◽  
Disease Transmission ◽  
Particle Production ◽  
Great Majority ◽  
Transmission Risk ◽  
Linear Regression Models ◽  
Tidal Breathing ◽  
High Production ◽  
Over Time

The size and concentration of exhaled particles may influence respiratory infection transmission risk. We assessed variation in exhaled particle production between individuals, factors associated with high production and stability over time.We measured exhaled particle production during tidal breathing in a sample of 79 healthy volunteers, using optical particle counter technology. Repeat measurements (several months after baseline) were obtained for 37 of the 79 participants.   Multilevel linear regression models of log transformed particle production measures were used to assess risk factors for high production.  Stability between measurements over time was assessed using Lin’s correlation coefficients.Ninety-nine percent of expired particles were <1μm in diameter. Considerable variation in exhaled particle production was observed between individuals and within individuals over time. Distribution of particle production was right skewed.  Approximately 90% of individuals produce <150 particles per litre in normal breathing.  A few individuals had measurements of over 1000 particles per litre (maximum 1456). Particle production increased with age (p<0.001) and was associated with high tree pollen counts. Particle production levels did not remain stable over time [rho 0.14 (95%CI -0.10, 0.38, p=0.238)].Sub-micron particles conducive to airborne rather than droplet transmission form the great majority of exhaled particles in tidal breathing. There is a high level of variability between subjects but measurements are not stable over time. Production increases with age and may be influenced by airway inflammation caused by environmental irritants. Further research is needed to determine whether the observed variations in exhaled particle production affect transmission of respiratory infection.

Supplementing Access to Social Capital Over Time: Computer-Mediated Communication Competence for Social-Resource Development

2019 ◽  
pp. 089443931989550
Author(s):  
Brandon C. Bouchillon
Keyword(s):  
Social Capital ◽  
Computer Mediated Communication ◽  
Social Contact ◽  
Resource Development ◽  
Occupational Prestige ◽  
Social Resource ◽  
Mediated Communication ◽  
Computer Mediated ◽  
Computer Based ◽  
Over Time

Social capital has been declining in America for the better part of a century, as citizens now find themselves connected to fewer people and resources. But computer-based modes of social contact have at the same time opened up new frontiers for expanding and developing personal relationships online. A two-wave U.S. web survey was used to examine the importance of computer-mediated communication (CMC) competence for social-resource development, measured in terms of occupational prestige. CMC competence related to acquiring more total resources over time. It also contributed to accessing a wider range of resources and having more valuable connections on average. When CMC competence was broken down into subscale measures, computer-based motivation contributed to total resources and range in resources, while computer-based attentiveness related to developing better resources. Findings speak to the value of CMC competence for social capital and the waning influence of interpersonal competence in general.

Evaluating Social Interaction and Support Methods Over Time

2014 ◽  
Vol 4 (3) ◽  
pp. 1-17 ◽  
Author(s):  
Birgitta Maria Kopp
Keyword(s):  
Social Interaction ◽  
Group Dynamics ◽  
Subjective Evaluation ◽  
Positive Influence ◽  
Specific Pattern ◽  
Computer Supported Collaborative Learning ◽  
Computer Based Learning ◽  
Computer Based ◽  
Support Methods ◽  
Over Time

This research focuses on the evaluation of social interaction and support methods for computer-supported collaborative learning over the period of one semester. Specifically, there are three main topics for investigation: first, the subjective evaluation of social interaction and support methods, second, the students' perceptions of these over time, and third, the correlations between social interaction and support methods. Results indicate a specific pattern regarding important aspects of social interaction indicating possible problems in group dynamics (especially relating to taking responsibility). This evaluation pattern remains nearly constant over time. Furthermore, correlation analyses show strong connections between the design of group work and group dynamics, indicating a positive influence of support methods on problematic dimensions of social interaction. As this relation is strongest during the middle phase of collaboration, this study gives a first indication that also CSCL groups may go through the storming and norming stage of collaboration. These findings substantiate the necessity of providing support for computer-based learning.

Reproducible activation in BA2, 1 and 3b associated with texture discrimination in healthy volunteers over time

NeuroImage ◽  
2008 ◽  
Vol 39 (1) ◽  
pp. 40-51 ◽  
Author(s):  
Leeanne M. Carey ◽  
David F. Abbott ◽  
Gary F. Egan ◽  
Geoffrey A. Donnan
Keyword(s):  
Healthy Volunteers ◽  
Texture Discrimination ◽  
Over Time

P.1.c.001 Acute psychomotor, memory and subjective effects of MDMA and THC (co-) administration over time in healthy volunteers

2010 ◽  
Vol 20 ◽  
pp. S235-S236
Author(s):  
G. Dumont ◽  
J. van Hasselt ◽  
M. de Kam ◽  
J. van Gerven ◽  
D. Touw ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Subjective Effects ◽  
Over Time
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