Therapeutic Implications of Immune Suppression

2015 ◽  
pp. 383-391
Author(s):  
Helmut J. Bauer
Keyword(s):  
Immune Suppression ◽  
Therapeutic Implications

scholarly journals Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications

2021 ◽  
Vol 11 ◽  
Author(s):  
Benjamin T. Himes ◽  
Philipp A. Geiger ◽  
Katayoun Ayasoufi ◽  
Adip G. Bhargav ◽  
Desmond A. Brown ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Suppressor Cells ◽  
Primary Brain Tumor ◽  
Current Understanding ◽  
Therapeutic Implications ◽  
Novel Treatments ◽  
New Therapeutic Approaches ◽  
Current State ◽  
Downstream Effectors

Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy has remained largely unchanged in recent years as new therapeutic approaches have struggled to demonstrate benefit. One of the most challenging hurdles to overcome in developing novel treatments is the profound immune suppression found in many GBM patients. This limits the utility of all manner of immunotherapeutic agents, which have revolutionized the treatment of a number of cancers in recent years, but have failed to show similar benefit in GBM therapy. Understanding the mechanisms of tumor-mediated immune suppression in GBM is critical to the development of effective novel therapies, and reversal of this effect may prove key to effective immunotherapy for GBM. In this review, we discuss the current understanding of tumor-mediated immune suppression in GBM in both the local tumor microenvironment and systemically. We also discuss the effects of current GBM therapy on the immune system. We specifically explore some of the downstream effectors of tumor-driven immune suppression, particularly myeloid-derived suppressor cells (MDSCs) and other immunosuppressive monocytes, and the manner by which GBM induces their formation, with particular attention to the role of GBM-derived extracellular vesicles (EVs). Lastly, we briefly review the current state of immunotherapy for GBM and discuss additional hurdles to overcome identification and implementation of effective therapeutic strategies.

Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression

2007 ◽  
Vol 19 (5) ◽  
pp. 583-588 ◽  
Author(s):  
B LI ◽  
S SAOUAF ◽  
A SAMANTA ◽  
Y SHEN ◽  
W HANCOCK ◽  
...  
Keyword(s):  
Immune Suppression ◽  
Therapeutic Implications

Pregabalin and gabapentin treatment in MS patients: Clinical experiences and therapeutic implications

2011 ◽  
Vol 42 (01) ◽  
Author(s):  
S. Bittner ◽  
K.G. Höhn ◽  
K. Göbel ◽  
H. Wiendl ◽  
S.G. Meuth
Keyword(s):  
Clinical Experiences ◽  
Therapeutic Implications

Changes in Adrenocortical Function with Aging and Therapeutic Implications

1999 ◽  
Vol Volume 17 (Number 4) ◽  
pp. 0327-0338 ◽  
Author(s):  
Andrew J. Harper ◽  
John E. Buster ◽  
Peter R. Casson
Keyword(s):  
Adrenocortical Function ◽  
Therapeutic Implications

Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

2020 ◽  
Vol 3 (2) ◽  
pp. 216-242 ◽  
Author(s):  
Mayuri Shukla ◽  
Areechun Sotthibundhu ◽  
Piyarat Govitrapong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adult Neurogenesis ◽  
Adult Brain ◽  
Therapeutic Approaches ◽  
Therapeutic Implications ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.   

Sign in / Sign up

Export Citation Format

Share Document