Circadian Rhythms in Affective Disorders

2015 ◽  
pp. 114-127 ◽  
Author(s):  
Domien G. M. Beersma ◽  
Rudi H. van den Hoofdakker ◽  
Hans W. B. M. van Berkestijn
Keyword(s):  
Circadian Rhythms ◽  
Affective Disorders

Affective Disorders and Circadian Rhythms

1986 ◽  
Vol 31 (3) ◽  
pp. 259-272 ◽  
Author(s):  
J.D. Hallonquist ◽  
M.A. Goldberg ◽  
J.S. Brandes
Keyword(s):  
At Risk ◽  
Circadian Rhythms ◽  
Causal Relationship ◽  
Affective Disorders ◽  
Bipolar Depression ◽  
Circadian System ◽  
Therapeutic Interventions ◽  
Circadian Dysfunction

Abnormal circadian rhythms have been associated with affective disorders. A review of this rapidly expanding area of investigation shows that while a clear causal relationship has not yet been proven, a knowledge of the circadian system and its dysfunction can help in understanding unipolar and bipolar depression. Evidence suggests that existing therapies such as lithium and antidepressants act upon the circadian system. Better identification of individuals at risk for affective disorders and the development of new preventive and therapeutic interventions may result from further study of circadian dysfunction.

scholarly journals Sleep and Depression: What We Know and What to Learn?

2020 ◽  
pp. 33-49
Author(s):  
Andrey Viktorovich Antsyborov ◽  
Anna Valerievna Kalinchuk ◽  
Irina Vladimirovna Dubatova
Keyword(s):  
Obstructive Sleep Apnea ◽  
Circadian Rhythms ◽  
Affective Disorders ◽  
Sleep Disturbances ◽  
Biological Clock ◽  
The Core ◽  
Obstructive Sleep ◽  
Function Of Sleep ◽  
Depressive Episodes

Presently, a lot of data indicate that the disturbance of mechanisms underlying the regulation of sleep-waking cycle coincides with the mechanisms underlying the development of depression. The disturbance of circadian rhythms is one of the core factors in the genesis of the most affective disorders including depression, which indicates the role of the internal biological clock in the pathophysiology of affective disorders. The episodes of depression, mania or hypomania may result from the disturbances in endogenous biological timing. In this review, we have summarized the literature data obtained in animal models or in the patients with affective pathology, in which the connection between the function of sleep and depression was demonstrated. Specifically, we highlight the mechanisms underlying sleep dysfunction during depression (imbalance of circadian rhythms, melatonin metabolism and mechanisms of neuroinflammatory dysregulation) and provide an evidence for the link between sleep function and depression (sleep disturbances during depressive episodes, the effects of pharmacotherapy, chronotherapy, the effect of sleep deprivation, comorbidity of obstructive sleep apnea and depression).

Molecular Link between Circadian Rhythmicity and Mood Disorders

2021 ◽  
Vol 28 ◽  
Author(s):  
Frank Faltraco ◽  
Denise Palm ◽  
Andrew Coogan ◽  
Frederick Simon ◽  
Oliver Tucha ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Mood Disorders ◽  
Affective Disorders ◽  
Current Knowledge ◽  
Unipolar Depression ◽  
Internal Clock ◽  
Circadian Genes ◽  
Pubmed Database

Background: The internal clock is driven by circadian genes [e.g., Clock, Bmal1, Per1-3, Cry1-2], hormones [e.g., melatonin, cortisol], as well as zeitgeber [‘synchronisers’]. Chronic disturbances in the circadian rhythm in patients diagnosed with mood disorders have been recognised for more than 50 years. Objectives: The aim of this review is to summarise the current knowledge and literature regarding circadian rhythms in the context of mood disorders, focussing on the role of circadian genes, hormones, and neurotransmitters. Method: The review presents the current knowledge and literature regarding circadian rhythms in mood disorders using the Pubmed database. Articles with a focus on circadian rhythms and mood disorders [n=123], particularly from 1973 to 2020, were included. Results: The article suggests a molecular link between disruptions in the circadian rhythm and mood disorders. Circadian disturbances, caused by the dysregulation of circadian genes, hormones, and neurotransmitters, often result in a clinical picture resembling depression. Conclusion: Circadian rhythms are intrinsically linked to affective disorders, such as unipolar depression and bipolar disorder.

Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders

2017 ◽  
Vol 94 ◽  
pp. 131-138 ◽  
Author(s):  
Joanne S. Carpenter ◽  
Rébecca Robillard ◽  
Daniel F. Hermens ◽  
Sharon L. Naismith ◽  
Christopher Gordon ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Young People ◽  
Core Temperature ◽  
Affective Disorders

Effects of Phototherapy on Circadian Rhythms of Body Temperature in Affective Disorders

1992 ◽  
Vol 46 (1) ◽  
pp. 240-240
Author(s):  
Kazushi Daimon ◽  
Naoto Yamada ◽  
Tetsushi Tsujimoto ◽  
Toshiki Shioiri ◽  
Koichi Hanada ◽  
...  
Keyword(s):  
Body Temperature ◽  
Circadian Rhythms ◽  
Affective Disorders

scholarly journals Comorbidities, Depression Severity, and Circadian Rhythms Disturbances as Clinical Correlates of Duration of Untreated Illness in Affective Disorders

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 459
Author(s):  
Giulia Menculini ◽  
Norma Verdolini ◽  
Francesca Brufani ◽  
Valentina Pierotti ◽  
Federica Cirimbilli ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Circadian Rhythms ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Rating Scale ◽  
Biological Rhythms ◽  
Point Of View ◽  
Clinical Severity ◽  
Duration Of Untreated Illness ◽  
Syndrome Scale

Background and Objectives: Affective disorders, namely bipolar (BDs) and depressive disorders (DDs) are characterized by high prevalence and functional impairment. From a dimensional point of view, BDs and DDs can be considered as psychopathological entities lying on a continuum. A delay in treatment initiation might increase the burden associated with affective disorders. The aim of this study is to analyze the correlates of a long duration of untreated illness (DUI) in these conditions. Materials and Methods: Subjects with BDs and DDs, both in- and outpatients, were recruited. Long DUI was defined according to previous research criteria as >2 years for BDs or >1 year for DDs. Socio-demographic, clinical and psychopathological characteristics of the recruited subjects were collected. Bivariate analyses were performed to compare subjects with a long and short DUI (p < 0.05). Results: In our sample (n = 61), 34.4% of subjects presented a long DUI. A long DUI was significantly associated with longer overall illness duration (p = 0.022) and a higher rate of psychiatric (p = 0.048) and physical comorbidities (p = 0.023). As for psychopathological features, depressive symptoms were more severe in the long DUI subgroup, as demonstrated by a higher score at the Clinical Global Impression-severity of depression (p = 0.012) item and at the anxiety/depression factor of the Positive and Negative Syndrome Scale (p = 0.041). Furthermore, subjects with a long DUI displayed more severe disruption of circadian rhythms, as evaluated by the Biological Rhythms Interview for Assessment in Neuropsychiatry total (p = 0.044) and social domain (p = 0.005) scores and by the Hamilton Depression Rating Scale diurnal variation items (18a: p = 0.029, 18b: p = 0.047). Conclusions: A long DUI may underpin higher clinical severity, as well as worse illness course and unfavorable prognosis in affective disorders. Intervention strategies targeting comorbidities, depressive symptoms and circadian rhythms may decrease disease burden in subjects with a long DUI.

Sign in / Sign up

Export Citation Format

Share Document