Stimulus-Secretion Coupling

2015 ◽  
pp. 52-72 ◽  
Author(s):  
Ronald P. Rubin
Keyword(s):  
Stimulus Secretion Coupling

The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine

Diabetes ◽  
1980 ◽  
Vol 29 (6) ◽  
pp. 431-437 ◽  
Author(s):  
W. J. Malaisse ◽  
J. C. Hutton ◽  
A. R. Carpinelli ◽  
A. Herchuelz ◽  
A. Sener
Keyword(s):  
Amino Acid ◽  
Insulin Release ◽  
Stimulus Secretion Coupling

Stimulus-secretion coupling of arginine-induced insulin release

1989 ◽  
Vol 38 (2) ◽  
pp. 327-330 ◽  
Author(s):  
A. Sener ◽  
P. Lebrun ◽  
F. Blachier ◽  
W.J. Malaisse
Keyword(s):  
Insulin Release ◽  
Stimulus Secretion Coupling

scholarly journals The effect of nickel on secretory systems. Studies on the release of amylase, insulin and growth hormone

1974 ◽  
Vol 140 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Robert L. Dormer ◽  
Alan L. Kerbey ◽  
Margaret McPherson ◽  
Susan Manley ◽  
Stephen J. H. Ashcroft ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Energy Metabolism ◽  
Cyclic Amp ◽  
Inhibitory Action ◽  
Substrate Oxidation ◽  
Tissue Concentrations ◽  
Mouse Pancreatic Islets ◽  
Stimulus Secretion Coupling ◽  
Potential Use ◽  
Systems Studies

The effects of Ni2+ on the release of amylase from rat parotids, insulin from mouse pancreatic islets and growth hormone from bovine pituitary slices were investigated. In all these secretory systems, Ni2+ was shown to inhibit release evoked by a variety of stimuli both physiological and pharmacological. Measurements of rates of substrate oxidation and tissue concentrations of ATP and 3′:5′-cyclic AMP suggest that this inhibitory action of Ni2+ does not arise through an effect on energy metabolism or cyclic AMP metabolism. It is concluded that although some effects of Ni2+ may involve antagonism between Ni2+ and Ca2+ in stimulus–secretion coupling, others appear to be independent of Ca2+. It is suggested that Ni2+ may block exocytosis by interfering with either secretory-granule migration or membrane fusion and microvillus formation. The possible mode of action of Ni2+ and its potential use as a tool in the study of exocytosis are discussed.

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