Membrane Receptors and Hormone Action

2015 ◽  
pp. 1-51 ◽  
Author(s):  
Karen A. Valentine ◽  
Morley D. Hollenberg
Keyword(s):  
Membrane Receptors ◽  
Hormone Action

Principles of hormone action

2020 ◽  
pp. 2245-2257
Author(s):  
Rob Fowkes ◽  
V. Krishna Chatterjee ◽  
Mark Gurnell
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Vitamin D ◽  
Nuclear Receptors ◽  
Physiological Response ◽  
Membrane Receptors ◽  
Signalling Pathways ◽  
Hormone Action ◽  
Biochemical Pathways ◽  
Releasing Factors

Hormones, produced by glands or cells, are messengers which act locally or at a distance to coordinate the function of cells and organs. Types of hormone include: peptides (e.g. hypothalamic releasing factors) and proteins (e.g. insulin, growth hormone)—these generally interact with membrane receptors located on the cell surface, causing activation of downstream signalling pathways leading to alteration in gene transcription or modulation of biochemical pathways to effect a physiological response; steroids (e.g. cortisol, progesterone, testosterone, oestradiol) and other lipophilic substances (e.g. vitamin D, retinoic acid, thyroid hormone)—these act by crossing the plasma membrane to interact with intracellular receptors, with hormone action via nuclear receptors altering cellular gene expression directly.

scholarly journals Membrane receptors for hormones and neurotransmitters.

1976 ◽  
Vol 70 (2) ◽  
pp. 261-286 ◽  
Author(s):  
C R Kahn
Keyword(s):  
Hormone Receptors ◽  
Biological Function ◽  
Structure And Function ◽  
Membrane Receptors ◽  
Receptor Interaction ◽  
Hormone Action ◽  
Membrane Structure And Function ◽  
And Function ◽  
Mechanism Of Hormone Action ◽  
Synthesis And Degradation

Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotransmitter with its receptor is rapid, reversible, and of high affinity and specificity. Many receptors exhibit cooperative properties in hormone binding or biological function. The concentration of receptors on the membrane is a function of continued synthesis and degradation, and may be altered by a variety of factors including the hormone itself. The fluid mosaic nature of the membrane may allow hormone receptors and effectors to exist in free floating states. Further investigations of the hormone-receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.

Membrane receptors and hormone action: Recent developments

1978 ◽  
Vol 2 (3) ◽  
pp. 287-302 ◽  
Author(s):  
Morley D. Hollenberg ◽  
Pedro Cuatrecasas
Keyword(s):  
Membrane Receptors ◽  
Hormone Action ◽  
Recent Developments

Principles of hormone action

2010 ◽  
pp. 1787-1798
Author(s):  
Mark Gurnell ◽  
Jacky Burrin ◽  
V. Krishna Chatterjee
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Vitamin D ◽  
Nuclear Receptors ◽  
Physiological Response ◽  
Membrane Receptors ◽  
Signalling Pathways ◽  
Hormone Action ◽  
Biochemical Pathways ◽  
Releasing Factors

Hormones, produced by glands or cells, are messengers which act locally or at a distance to coordinate the function of cells and organs. Types of hormone include (1) peptides (e.g hypothalamic releasing factors) and proteins (e.g. insulin, growth hormone)—these generally interact with membrane receptors located on the cell surface, causing activation of downstream signalling pathways leading to alteration in gene transcription or modulation of biochemical pathways to effect a physiological response; (2) steroids (e.g. cortisol, progesterone, testosterone, oestradiol) and other lipophilic substances (e.g. vitamin D, retinoic acid, thyroid hormone)—these act by crossing the plasma membrane to interact with intracellular receptors, with hormone action via nuclear receptors altering cellular gene expression directly....

Membrane receptors mediating thyroid hormone action

2005 ◽  
Vol 16 (9) ◽  
pp. 429-435 ◽  
Author(s):  
Paul J. Davis ◽  
Faith B. Davis ◽  
Vivian Cody
Keyword(s):  
Thyroid Hormone ◽  
Membrane Receptors ◽  
Hormone Action ◽  
Thyroid Hormone Action
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