Experimental Studies on the Role of Preventive Measures in Acute Oliguric Ischemic Renal Failure

2015 ◽  
pp. 89-104
Author(s):  
H. J. Kramer ◽  
R. D�sing ◽  
D. Klingm�ller ◽  
F. Kr�ck
Keyword(s):  
Renal Failure ◽  
Preventive Measures ◽  
Experimental Studies ◽  
Ischemic Renal Failure

Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite

2007 ◽  
Vol 293 (6) ◽  
pp. H3542-H3549 ◽  
Author(s):  
Miguel G. Salom ◽  
Susana Nieto Cerón ◽  
Francisca Rodriguez ◽  
Bernardo Lopez ◽  
Isabel Hernández ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Beneficial Effects ◽  
Medullary Blood Flow ◽  
Ischemic Renal Failure ◽  
Oxide Synthase

The present study evaluated the effects of heme oxygenase-1 (HO-1) induction on the changes in renal outer medullary nitric oxide (NO) and peroxynitrite levels during 45-min renal ischemia and 30-min reperfusion in anesthetized rats. Glomerular filtration rate (GFR), outer medullary blood flow (OMBF), HO and nitric oxide synthase (NOS) isoform expression, and renal low-molecular-weight thiols (–SH) were also determined. During ischemia significant increases in NO levels and peroxynitrite signal were observed (from 832.1 ± 129.3 to 2,928.6 ± 502.0 nM and from 3.8 ± 0.7 to 9.0 ± 1.6 nA before and during ischemia, respectively) that dropped to preischemic levels during reperfusion. OMBF and –SH significantly decreased after 30 min of reperfusion. Twenty-four hours later, an acute renal failure was observed (GFR 923.0 ± 66.0 and 253.6 ± 55.3 μl·min−1·g kidney wt−1 in sham-operated and ischemic kidneys, respectively; P < 0.05). The induction of HO-1 (CoCl2 60 mg/kg sc, 24 h before ischemia) decreased basal NO concentration (99.7 ± 41.0 nM), although endothelial and neuronal NOS expression were slightly increased. CoCl2 administration also blunted the ischemic increase in NO and peroxynitrite (maximum values of 1,315.6 ± 445.6 nM and 6.3 ± 0.5 nA, respectively; P < 0.05), preserving postischemic OMBF and GFR (686.4 ± 45.2 μl·min−1·g kidney wt−1). These beneficial effects of CoCl2 on ischemic acute renal failure seem to be due to HO-1 induction, because they were abolished by stannous mesoporphyrin, a HO inhibitor. In conclusion, HO-1 induction has a protective effect on ischemic renal failure that seems to be partially mediated by decreasing the excessive production of NO with the subsequent reduction in peroxynitrite formation observed during ischemia.

scholarly journals Effect of immune-modulators (Rasayana Dravya) in Janapadodhwansa WSR to COVID-19

2020 ◽  
Vol 6 (1) ◽  
pp. 26-29
Author(s):  
Vaidya Pratigya Chauhan ◽  
◽  
Bhawna Dutt ◽  
Mahesh Vyas ◽  
S. K. Gupta ◽  
...  
Keyword(s):  
Health Care ◽  
Immune Response ◽  
21St Century ◽  
Preventive Measures ◽  
Experimental Studies ◽  
Collective Actions ◽  
Immune Modulators ◽  
Ancient Science ◽  
The People

Ayurveda provide a basic way of living to the people and mentioned the different “Charyas” to be done by the individuals in day to day life as well as this ancient science garlanded us with the knowledge and code of conducts to conduct different type of studies like experimental studies, survey studies etc. In this sequence, Janapadodhwansa, a chapter describes in Vimana Sthana by Acharya Charaka is considered as the chapter of epidemiological study. Where he explained the whole concept on handling the situation of pandemic state. Now, a days It is evident to notify the Pandemic state of China and different countries due to the virus knows as corona virus, which is responsible and causes pressure on societies and health care system. This is the first pandemic condition of 21st century which requires internationally unified cogent and collective actions by the individuals, communities, commercial bodies etc. Due to the novelty of the virus, there is no treatment known and no vaccination is available. Only social distancing and other preventive measures are tolls used to deal this emergency. And hence, this condition can be correlated with Janapadodhwansa. And Rasayana is one of them, which provide the strength against the viral condition and improve the immune response towards this pandemic disease. This article aims to provide information about role of Rasayana dravyas (Gudhuchi, Amalaki and Haridra) which can be in cooperated in day to day life and act as immune modulators.

The Role of Reduced Medullary Perfusion in the Genesis of Acute Ischemic Renal Failure

Nephron ◽  
1982 ◽  
Vol 31 (4) ◽  
pp. 321-323 ◽  
Author(s):  
G. Thiel ◽  
D. de Rougemont ◽  
W. Kriz ◽  
J. Mason ◽  
J. Torhorst ◽  
...  
Keyword(s):  
Renal Failure ◽  
Ischemic Renal Failure

scholarly journals Role of the medullary perfusion defect in the pathogenesis of ischemic renal failure

1984 ◽  
Vol 26 (3) ◽  
pp. 283-293 ◽  
Author(s):  
June Mason ◽  
Joachim Torhorst ◽  
Johanna Welsch
Keyword(s):  
Renal Failure ◽  
Perfusion Defect ◽  
Ischemic Renal Failure

Impaired Fibrinolysis in Obstructive Jaundice - Evidence from Clinical and Experimental Studies

1988 ◽  
Vol 60 (01) ◽  
pp. 025-029 ◽  
Author(s):  
M Colucci ◽  
D F Altomare ◽  
G Chetta ◽  
R Triggiani ◽  
L G Cavallo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Bile Duct ◽  
Obstructive Jaundice ◽  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Experimental Studies ◽  
Plasminogen Activator Inhibitor ◽  
Venous Stasis ◽  
Microvascular Thrombosis ◽  
Duct Ligation

SummaryMicrovascular thrombosis is considered an important pathogenetic factor in renal failure associated with obstructive jaundice but the mechanisms leading to fibrin deposition are still unknown. The plasma levels of plasminogen activator inhibitor (PAI) in 29 patients with obstructive jaundice were found significantly increased as compared to 20 nonjaundiced patients. Fibrin autography of plasma supplemented with tissue plasminogen activator (t-PA) revealed that in icteric samples most of the added activator migrated with an apparent Mr of 100 kDa, corresponding to t-PA-PAI complex, whereas in control samples virtually all t-PA migrated as free enzyme. PAI activity detected in icteric samples is similar to the endothelial type PAI since it is neutralized by a monoclonal antibody against PAI-1.Venous stasis in jaundiced patients was neither associated with an increase in blood fibrinolytic activity nor with a decrease in PAI activity. Immunologic assay showed that t-PA release was impaired in 3 out of 4 patients. In controls, venous occlusion induced an increase in both fibrinolytic activity and t-PA antigen and a reduction in PAI activity. Bile duct recanalization in jaundiced patients subjected to surgery was accompanied by a decrease in plasma PAI activity which paralleled the decrease in serum bilirubin levels. In nonjaundiced patients, surgical treatment did not cause significant changes in either parameter. Rabbits made icteric by bile duct ligation showed an early and progressive increase in plasma PAI activity indicating that obstructive jaundice itself causes the elevation of circulating PAI. It is concluded that obstructive jaundice is associated with a severe impairment of fibrinolysis which might contribute to microvascular thrombosis and renal failure.

Covid-19 – rumours and facts in media

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 171-174
Author(s):  
Tarare Toshida ◽  
Chaple Jagruti
Keyword(s):  
Social Media ◽  
Preventive Measures ◽  
Vital Role ◽  
The Other ◽  
Sources Of Information ◽  
Other Hand ◽  
Corona Virus ◽  
The People ◽  
The World

The covid-19 resulted in broad range of spread throughout the world in which India has also became a prey of it and in this situation the means of media is extensively inϑluencing the mentality of the people. Media always played a role of loop between society and sources of information. In this epidemic also media is playing a vital role in shaping the reaction in ϑirst place for both good and ill by providing important facts regarding symptoms of Corona virus, preventive measures against the virus and also how to deal with any suspect of disease to overcome covid-19. On the other hand, there are endless people who spread endless rumours overs social media and are adversely affecting life of people but we always count on media because they provide us with valuable answers to our questions, facts and everything in need. Media always remains on top of the line when it comes to stop the out spread of rumours which are surely dangerous kind of information for society. So on our side we should react fairly and maturely to handle the situation to keep it in the favour of humanity and help government not only to ϑight this pandemic but also the info emic.

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