Raised Concentration of a Circulating Na+-K+-ATPase Inhibitor in Essential Hypertension

2015 ◽  
pp. 185-191 ◽  
Author(s):  
H. E. de Wardener ◽  
S. Fenton ◽  
J. Alaghband-Zadeh ◽  
G. A. MacGregor
Keyword(s):  
Essential Hypertension ◽  
Atpase Inhibitor

The Role of Na,K-ATPase Inhibitor on Pressor Responsiveness in Patients With Benign Essential Hypertension

1990 ◽  
Vol 3 (3) ◽  
pp. 176-181 ◽  
Author(s):  
Izumi Yamaji ◽  
Kenjiro Kikuchi ◽  
Mitsuhiro Nishimura ◽  
Akihiko Nozawa ◽  
Tohru Hasegawa ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Atpase Inhibitor

Effect of Dietary Sodium on the Na-K ATPase Inhibitor in Patients With Essential Hypertension

1989 ◽  
Vol 2 (7) ◽  
pp. 560-562 ◽  
Author(s):  
Terunao Ashida ◽  
Mono Kuramochi ◽  
Shunichi Kojima ◽  
Hiroki Yoshimi ◽  
Yuhei Kawano ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Dietary Sodium ◽  
Atpase Inhibitor

Interactions Between Insulin and Angiotensin II on Calcium Mobilization in Skin Fibroblasts from Insulin Resistant Patients with Essential Hypertension

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 726-726
Author(s):  
Ceolotto Giulio ◽  
Baritono Elisabetta ◽  
Valente Roberto ◽  
Monari Alessandra ◽  
Reato Stefania ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Angiotensin Ii ◽  
Mrna Expression ◽  
Pertussis Toxin ◽  
Inhibitory Effect ◽  
Skin Fibroblasts ◽  
Ang Ii ◽  
Atpase Inhibitor ◽  
Specific Primers ◽  
Insulin Resistant

P181 Objectives: Insulin attenuates angiotensin II (Ang II)-induced Cai2+ mobilization in insulin sensitive (IS) control subjects. Therefore we compared the interactions between Ang II and insulin on Cai2+ mobilization in skin fibroblasts from insulin resistant (IR) and insulin sensitive (IS) patients with essential hypertension (HT). Methods: Skin fibroblasts from 9 normotensives (NT) and 18 HT were cultured and used after 4 passages. Ca2+ was measured in monolayers of 24h serum-deprived cells using Fura-2 AM. mRNA expression of Gαi2 subunit was determined by RT-PCR using a 5 and 3 specific primers. Results: Resting and Ang II-stimulated (100nM) Cai2+ peak were higher in fibroblasts from HT than NT (76±3 vs 62±3 nM, p<0.01 and 225±8 vs 164±12 nM, p<0.01). In the absence of extracellular Ca2+, the Cai2+ response to Ang II was still significantly enhanced in fibroblasts from HT (212±8 vs 158±9 nM, p<0.01). Thapsigargin (500 nM), a Ca2+ -ATPase inhibitor, induced a Cai2+ rise that was similar in HT and NT (from 42±7 to 93±15 vs 52±5 to 106±8 nM). Pertussis toxin (20ng/ml, 6h), inhibitor of Gαi2 subunit, reduced Ang II stimulated Cai2+ peak both in NT (from 153±7 to 98±8nM, p<0.01) and HT (from 189±16 to 138±12, p<0.01). In IS HT, insulin (100 nM, 20 min) blunted the Ang II stimulated Cai2+ response (from 208±9 to 167±9 nM, p<0.01), while in IR HT it did not (from 205±16 to 208±13 nM, ns). Pertussis toxin attenuated AngII stimulated Cai2+ peak in IS HT (from 208±4 to 112±2 p<0.01), but not in IR HT (from 207±10 to 165±9). mRNA expression of Gαi2 subunit was increased in IR HT compared to IS HT. Conclusion: In human skin fibroblasts the inhibitory effect of insulin on Ang II - induced Cai2+ mobilization is blunted in IR HT by a pertussis toxin sensitive mechanism, probably involving a Gαi2subunit.

Predominance of High Molecular Weight Plasma Na+-K+-ATPase Inhibitor in Essential Hypertension

1993 ◽  
Vol 6 (8) ◽  
pp. 680-687 ◽  
Author(s):  
Harvey C. Gonick ◽  
Elmar W.J. Weiler ◽  
Farhad Khalil-Manesh ◽  
Michael A. Weber
Keyword(s):  
Molecular Weight ◽  
Essential Hypertension ◽  
High Molecular Weight ◽  
Atpase Inhibitor

Short-term Plasma Renin Activity Suppression by Saline and Release of a Plasma Endogenous Na/K ATPase Inhibitor in Essential Hypertension

1990 ◽  
Vol 3 (2) ◽  
pp. 98-104 ◽  
Author(s):  
Claudio Borghi ◽  
Stefano Boschi ◽  
Alessandra Munarini ◽  
Alessandra Mussi ◽  
Francesco Vittori. Costa ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Plasma Renin ◽  
Renin Activity ◽  
Atpase Inhibitor ◽  
Short Term
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