Intracellular Electrolytes and Hypertension

2015 ◽  
pp. 179-184 ◽  
Author(s):  
H. Losse ◽  
W. Zidek ◽  
H. Vetter
Keyword(s):  
Intracellular Electrolytes

MEASUREMENT OF BODY WATER AND INTRACELLULAR ELECTROLYTES BY MEANS OF MUSCLE BIOPSY

The Lancet ◽  
1967 ◽  
Vol 290 (7527) ◽  
pp. 1172-1176 ◽  
Author(s):  
J.A. Graham ◽  
J.F. Lamb ◽  
A.L. Linton
Keyword(s):  
Muscle Biopsy ◽  
Body Water ◽  
Intracellular Electrolytes

Intracellular Electrolytes in Essential Hypertension during Treatment with Torasemide

1987 ◽  
pp. 261-264
Author(s):  
C. Spieker ◽  
W. Zidek ◽  
W. Häcker ◽  
W. Schmidt ◽  
W. Tenschert ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Intracellular Electrolytes

RELATIONS OF INTRACELLULAR IONS TO METABOLITE SEQUENCES IN MUSCLE IN KWASHIORKOR

PEDIATRICS ◽  
1960 ◽  
Vol 26 (6) ◽  
pp. 960-972
Author(s):  
Jack Metcoff ◽  
Silvestre Frenk ◽  
Irena Antonowicz ◽  
Gustavo Gordillo ◽  
Elizabeth Lopez
Keyword(s):  
Citric Acid Cycle ◽  
Potassium Phosphate ◽  
Sodium Pyruvate ◽  
Intracellular Electrolytes ◽  
Intermediary Metabolite ◽  
Time Of Admission ◽  
Intracellular Ions ◽  
Potassium Magnesium ◽  
Pyruvate Ratio ◽  
Cellular Swelling

A biopsy was obtained at the time of admission and subsequently from eight children with severe kwashiorkor. The biopsies were analyzed for electrolyte content and for the quantities of certain intermediates (pyruvate, lactate, citrate and alphaketoglutarate). The results in five children who recovered are compared with those from three children who died. Significant reductions occurred in intracellular potassium, phosphate, magnesium and pyruvate, but lactate and alpha-ketoglutarate were increased. When the intracellular electrolytes were related to a specific intermediary metabolite (on the premise that the ion served as an activator or inhibitor in an enzymatic sequence leading to the production or the utilization of that intermediate) the changes assumed greater significance. A more dynamic interpretation of the data was provided by comparing ion:metabolite ratios of the initial with those of the second biopsy in patients who either recovered or died. Death from kwashiorkor was associated with a marked reversal in the sodium: pyruvate ratio and the apparent inorganic and organic phosphate to pyruvate ratios within the cell. These changes are consistent with some defect in the formation of pyruvate from phosphoenolpyruvate in a potassium-, magnesium-, phosphorus-dependent system. The citrate, magnesium and "true" inorganic phosphate to alphaketoglutarate ratios also were reversed in children who died compared to those who recovered. Such changes indicate a possible inhibition in the usual citric acid cycle pathway along which alpha-ketoglutarate is metabolized. Preliminary data on concentrations of phosphoenolpyruvate, isocitrate and oxalacetate within the muscle cell and on the activities of pyruvic kinase also are presented. The data are consistent with the hypothesis that the cellular swelling (in muscle) often characteristic of kwashiorkor leads to reduction in concentration of essential intracellular ions with inhibition of intermediary energy metabolism, thus leading to death. Since intracellular ions may function as activators or inhibitors for specific enzymes, it is suggested that changing quantities of a particular ion may be referred to the quantity of metabolite forming substrate or product of the specific enzymatic sequence. Altered ratios of ions to appropriate metabolites emphasize the possible significance of intracellular electrolytes in the biological system.

Changes in Erythrocyte Membrane Ouabain-Sensitive Adenosine Triphosphatase after Renal Transplantation

1975 ◽  
Vol 48 (3) ◽  
pp. 239-242 ◽  
Author(s):  
C. H. Cole ◽  
R. Maletz
Keyword(s):  
Renal Transplantation ◽  
Atpase Activity ◽  
Erythrocyte Membrane ◽  
Adenosine Triphosphatase ◽  
Inorganic Phosphorus ◽  
Erythrocyte Membranes ◽  
Healthy Controls ◽  
Intracellular Electrolytes ◽  
Transplant Patients ◽  
The Mean

1. Intracellular electrolytes, and erythrocyte membrane adenosine triphosphatase (ATPase) activity, was studied in twenty patients after renal transplantation. 2. The mean ouabain-sensitive ATPase activity in the erythrocyte membranes of the transplant patients was 122 nmol of inorganic phosphorus (Pi) h−1 mg of tissue−1 (sem 14), compared with 62 nmol of Pi h−1 mg of tissue−1 (sem 8) in a group of paired, healthy controls. 3. The increase in ouabain-sensitive ATPase was most marked in the 4 months after transplantation. However, a significant increase in ouabain-sensitive ATPase persisted for more than 8 months after transplantation. 4. This increase in ouabain-sensitive ATPase was associated with a decrease in intracellular sodium in the erythrocytes of the transplant patients.

Regulation of protein synthesis, intracellular electrolytes and cataract formation in vitro

Nature ◽  
1977 ◽  
Vol 270 (5636) ◽  
pp. 406-411 ◽  
Author(s):  
Toshimichi Shinohara ◽  
Joram Piatigorsky
Keyword(s):  
Protein Synthesis ◽  
Cataract Formation ◽  
Intracellular Electrolytes

scholarly journals The effect of environmental temperature on prandial changes in leucocyte sodium transport in man

1989 ◽  
Vol 62 (3) ◽  
pp. 639-645 ◽  
Author(s):  
L. L. Ng ◽  
T. D. R. Hockaday
Keyword(s):  
Sodium Transport ◽  
Room Temperature ◽  
Environmental Temperature ◽  
Normal Subjects ◽  
Efflux Rate ◽  
Intracellular Electrolytes ◽  
Daily Energy ◽  
Na Efflux ◽  
Efflux Rate Constant ◽  
Environmental Temperatures

Cellular sodium transport via the Na+, K+-ATPase contributes significantly to daily energy expenditure. The effect of a meal on leucocyte Na+ transport and intracellular electrolytes was therefore investigated in lean normal subjects at room temperatures of 23° and 33°, to determine if the Na pump responds to the need for thermogenesis. In the fasting state, the ouabain-sensitive efflux rate which reflects active Na+ transport, and the intracellular electrolytes were similar. At 2 h after eating a 4·2 MJ (1000 kcal) meal, the ouabain-sensitive efflux rate constant rose when the room temperature was 23° but not at 33°. The ouabain-sensitive Na+ efflux rate, an index of active Na+ transport, 0rose post-prandially at 23° only. The post-prandial activation of leucocyte active Na efflux in normal subjects was blunted at higher environmental temperatures, when the need for thermogenesis was reduced.

Intracellular Electrolytes During Antihypertensive Treatment with a Loop Diuretic

1984 ◽  
Vol 2 (4) ◽  
pp. 393-395 ◽  
Author(s):  
Walter Zidek ◽  
Heinz Losse ◽  
Werner Schmidt ◽  
Klaus J. Fehske ◽  
Hans Vetter
Keyword(s):  
Antihypertensive Treatment ◽  
Loop Diuretic ◽  
Intracellular Electrolytes
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