Genetic Regulation of Expression of Mammalian Lysosomal Enzymes

2015 ◽  
pp. 55-71
Author(s):  
Aidons J. Lusis
Keyword(s):  
Lysosomal Enzymes ◽  
Genetic Regulation ◽  
Regulation Of Expression

Transferrin: Evolution and Genetic Regulation of Expression

1988 ◽  
pp. 1-38 ◽  
Author(s):  
Barbara H. Bowman ◽  
Funmei Yang ◽  
Gwendolyn S. Adrian
Keyword(s):  
Genetic Regulation ◽  
Regulation Of Expression

scholarly journals Network Analysis Prioritizes DEWAX and ICE1 as the Candidate Genes for Major eQTL Hotspots in Seed Germination

2020 ◽  
Author(s):  
Margi Hartanto ◽  
Ronny V. L. Joosen ◽  
Basten L. Snoek ◽  
Leo A. J. Willems ◽  
Mark G. Sterken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Network Analysis ◽  
Seed Germination ◽  
Recombinant Inbred Lines ◽  
Genetic Regulation ◽  
Regulation Of Gene Expression ◽  
Regulatory Genes ◽  
Regulation Of Expression ◽  
Trait Locus

AbstractSeed germination is characterized by a constant change of gene expression across different time points. These changes are related to specific processes, which eventually determine the onset of seed germination. To get a better understanding on the regulation of gene expression during seed germination, we performed a quantitative trait locus mapping of gene expression (eQTL) at four important seed germination stages (primary dormant, after-ripened, six-hour after imbibition, and radicle protrusion stage) using Arabidopsis thaliana Bay x Sha recombinant inbred lines (RILs). The mapping displayed the distinctness of the eQTL landscape for each stage. We found several eQTL hotspots across stages associated with the regulation of expression of a large number of genes. Interestingly, an eQTL hotspot on chromosome five collocates with hotspots for phenotypic and metabolic QTLs in the same population. Finally, we constructed a gene co-expression network to prioritize the regulatory genes for two major eQTL hotspots. The network analysis prioritizes transcription factors DEWAX and ICE1 as the most likely regulatory genes for the hotspot. Together, we have revealed that the genetic regulation of gene expression is dynamic along the course of seed germination.One-sentence summaryTwo transcription factors, DEWAX and ICE1, may be important regulators of gene expression during seed germination, based on network analysis of eQTL hotspots.

scholarly journals Network Analysis Prioritizes DEWAX and ICE1 as the Candidate Genes for Major eQTL Hotspots in Seed Germination of Arabidopsis thaliana

2020 ◽  
Vol 10 (11) ◽  
pp. 4215-4226
Author(s):  
Margi Hartanto ◽  
Ronny V. L. Joosen ◽  
Basten L. Snoek ◽  
Leo A. J. Willems ◽  
Mark G. Sterken ◽  
...  
Keyword(s):  
Gene Expression ◽  
Arabidopsis Thaliana ◽  
Network Analysis ◽  
Seed Germination ◽  
Recombinant Inbred Lines ◽  
Genetic Regulation ◽  
Regulation Of Gene Expression ◽  
Regulatory Genes ◽  
Regulation Of Expression ◽  
Trait Locus

Seed germination is characterized by a constant change of gene expression across different time points. These changes are related to specific processes, which eventually determine the onset of seed germination. To get a better understanding on the regulation of gene expression during seed germination, we performed a quantitative trait locus mapping of gene expression (eQTL) at four important seed germination stages (primary dormant, after-ripened, six-hour after imbibition, and radicle protrusion stage) using Arabidopsis thaliana Bay x Sha recombinant inbred lines (RILs). The mapping displayed the distinctness of the eQTL landscape for each stage. We found several eQTL hotspots across stages associated with the regulation of expression of a large number of genes. Interestingly, an eQTL hotspot on chromosome five collocates with hotspots for phenotypic and metabolic QTL in the same population. Finally, we constructed a gene co-expression network to prioritize the regulatory genes for two major eQTL hotspots. The network analysis prioritizes transcription factors DEWAX and ICE1 as the most likely regulatory genes for the hotspot. Together, we have revealed that the genetic regulation of gene expression is dynamic along the course of seed germination.

scholarly journals Gene Regulation of Biofilm-Associated Functional Amyloids

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 490
Author(s):  
Khushal Khambhati ◽  
Jaykumar Patel ◽  
Vijaylaxmi Saxena ◽  
Parvathy A ◽  
Neha Jain
Keyword(s):  
Environmental Factors ◽  
Bacterial Communities ◽  
Genetic Regulation ◽  
Bacterial Cells ◽  
Regulation Of Expression ◽  
Form Of Life ◽  
Stringent Control ◽  
Factors Influencing ◽  
Functional Amyloids ◽  
Biofilm Matrix

Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids.

scholarly journals A λ Cro-Like Repressor Is Essential for the Induction of Conjugative Transfer of SXT/R391 Elements in Response to DNA Damage

2015 ◽  
Vol 197 (24) ◽  
pp. 3822-3833 ◽  
Author(s):  
Dominic Poulin-Laprade ◽  
Vincent Burrus
Keyword(s):  
Dna Damage ◽  
Multidrug Resistance ◽  
Pathogenic Bacteria ◽  
Diarrheal Disease ◽  
Genetic Regulation ◽  
Antibiotic Resistance Genes ◽  
Multidrug Resistant ◽  
Conjugative Transfer ◽  
Regulation Of Expression ◽  
Content Type

ABSTRACTIntegrative and conjugative elements (ICEs) of the SXT/R391 family are the main contributors to acquired multidrug resistance in the seventh pandemic lineage ofVibrio cholerae, the etiological agent of the diarrheal disease cholera. Conjugative transfer of SXT/R391 ICEs is triggered by antibiotics and agents promoting DNA damage through RecA-dependent autoproteolysis of SetR, an ICE-encoded λ CI-like repressor. Here, we describe the role of CroS, a distant λ Cro homolog, as a key component contributing to the regulation of expression of the activator SetCD that orchestrates the expression of the conjugative transfer genes. We show that deletion ofcroSabolishes the SOS response-dependent induction of SXT despite the presence of a functionalsetRgene. Using quantitative reverse transcription-PCR andlacZreporter assays, we also show that CroS repressessetRandsetCDexpression by binding to operator sites shared with SetR. Furthermore, we provide evidence of an additional operator site bound by SetR and CroS. Finally, we show that SetCD expression generates a positive feedback loop due to SXT excision and replication in a fraction of the cell population. Together, these results refine our understanding of the genetic regulation governing the propagation of major vectors of multidrug resistance.IMPORTANCEHealthcare systems worldwide are challenged by an alarming drug resistance crisis caused by the massive and rapid propagation of antibiotic resistance genes and the associated emergence of multidrug-resistant pathogenic bacteria. SXT/R391 ICEs contribute to this phenomenon not only in clinical and environmental vibrios but also in several members of the familyEnterobacteriaceae. We have identified and characterized here the regulator CroS as a key factor in the stimulation of conjugative transfer of these ICEs in response to DNA-damaging agents. We have also untangled conflicting evidence regarding autoactivation of transfer by the master activator of SXT/R391 ICEs, SetCD. Discovery of CroS provides a clearer and more complete understanding of the regulatory network that governs the dissemination of SXT/R391 ICEs in bacterial populations.

scholarly journals Genetic regulation of transcriptional variation in natural Arabidopsis thaliana accessions

2016 ◽  
Author(s):  
Yanjun Zan ◽  
Xia Shen ◽  
Simon K. G. Forsberg ◽  
Örjan Carlborg
Keyword(s):  
Arabidopsis Thaliana ◽  
Genetic Regulation ◽  
Global Gene Expression ◽  
Structural Variations ◽  
Regulation Of Expression ◽  
Cis Acting ◽  
Rna Transcripts ◽  
Genome Wide ◽  
Transcriptional Variation ◽  
Genome Wide Data

AbstractAn increased knowledge of the genetic regulation of expression in Arabidopsis thaliana is likely to provide important insights about the basis of the plant’s extensive phenotypic variation. Here, we reanalysed two publicly available datasets with genome-wide data on genetic and transcript variation in large collections of natural A. thaliana accessions. Transcripts from more than half of all genes were detected in the leaf of all accessions, and from nearly all annotated genes in at least one accession. Thousands of genes had high transcript levels in some accessions but no transcripts at all in others and this pattern was correlated with the genome-wide genotype. In total, 2,669 eQTL were mapped in the largest population, and 717 of them were replicated in the other population. 646 cis-eQTLs regulated genes that lacked detectable transcripts in some accessions, and for 159 of these we identified one, or several, common structural variants in the populations that were shown to be likely contributors to the lack of detectable RNA-transcripts for these genes. This study thus provides new insights on the overall genetic regulation of global gene-expression diversity in the leaf of natural A. thaliana accessions. Further, it also shows that strong cis-acting polymorphisms, many of which are likely to be structural variations, make important contributions to the transcriptional variation in the worldwide A. thaliana population.

Phenotypic dissection of bone mineral density facilitates the identification of skeletal site specificity on the genetic regulation of bone

2013 ◽  
Author(s):  
P Kemp John ◽  
Medina-Gomez Carolina ◽  
Estrada Karol ◽  
H M Heppe Denise ◽  
M Zillikens Carola ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Genetic Regulation ◽  
Site Specificity ◽  
Mineral Density ◽  
Skeletal Site

Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton

2017 ◽  
Author(s):  
Jonathan Mitchell ◽  
Alessandra Chesi ◽  
Shana McCormack ◽  
Diana Cousminer ◽  
Heidi Kalkwarf ◽  
...  
Keyword(s):  
Bone Density ◽  
Genetic Regulation ◽  
Principal Component
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