Control of Macrophage Stimulation and Proliferation

2015 ◽  
pp. 345-352 ◽  
Author(s):  
John A. Hamilton
Keyword(s):  
Macrophage Stimulation

scholarly journals Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

2010 ◽  
Vol 6 (1) ◽  
pp. e1000744 ◽  
Author(s):  
Kevin N. Couper ◽  
Tom Barnes ◽  
Julius C. R. Hafalla ◽  
Valery Combes ◽  
Bernhard Ryffel ◽  
...  
Keyword(s):  
Malaria Infection ◽  
Macrophage Stimulation

An arabinogalactan isolated from Boswellia carterii: Purification, structural elucidation and macrophage stimulation via NF-κB and MAPK pathways

2019 ◽  
Vol 52 ◽  
pp. 450-458 ◽  
Author(s):  
Saman Bahramzadeh ◽  
Mehdi Tabarsa ◽  
SangGuan You ◽  
Khamphone Yelithao ◽  
Vladimir Klochkov ◽  
...  
Keyword(s):  
Structural Elucidation ◽  
Mapk Pathways ◽  
Boswellia Carterii ◽  
Macrophage Stimulation

ENDOTOXIN TOLERANCE IMPAIRS MACROPHAGE STIMULATION BY TNF AND PDGF: GLOBAL CELLULAR DYSREGULATION?

Shock ◽  
2004 ◽  
Vol 21 (Supplement) ◽  
pp. 63
Author(s):  
W Heagy ◽  
N Du ◽  
A Remmenschneider ◽  
M A West
Keyword(s):  
Endotoxin Tolerance ◽  
Macrophage Stimulation

scholarly journals The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70 kDa Heat Shock Protein DnaK in Macrophage Stimulation

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Elias Blasius ◽  
Elke Gülden ◽  
Hubert Kolb ◽  
Christiane Habich ◽  
Volker Burkart
Keyword(s):  
Heat Shock ◽  
Cytokine Production ◽  
Interleukin 1 ◽  
The Core ◽  
Hsp70 Family ◽  
Macrophage Stimulation ◽  
Shock Proteins ◽  
Autoimmune Reactivity ◽  
Necrosis Factor

Background. Heat shock proteins (Hsp) act as intracellular chaperones and in addition are used as adjuvant in vaccines of peptides complexed with recombinant Hsp. By interacting with autologous peptides, Hsp may promote the induction of autoimmune reactivity. Objective. Here, we analysed whether the effect of Hsp on macrophages is modulated by insulin peptides known to interact with Hsp. Results. Combinations of the 70 kDa Hsp DnaK with peptide B11-23 from the core region of the proinsulin B-chain induced the release of the inflammatory mediators interleukin-6, tumor necrosis factor α, and interleukin-1β from cells of human and murine macrophage lines. In parallel, there was high-affinity binding of B11-23 to DnaK. DnaK mixed with peptides from other regions of the insulin molecule did not stimulate cytokine secretion. DnaK alone induced little cytokine production, and peptides alone induced none. Conclusion. The macrophage-stimulating potential of Hsp70 family proteins when combined with the proinsulin B-chain peptide B11-23 may contribute to the immunodominance of this peptide in the development of beta cell-directed autoimmunity in type 1 diabetes.

scholarly journals Enhancement of Macrophage Stimulation by Lipoteichoic Acid and the Costimulant Hemoglobin Is Dependent on Toll-Like Receptors 2 and 4

2007 ◽  
Vol 75 (5) ◽  
pp. 2638-2641 ◽  
Author(s):  
Kathleen H. Cox ◽  
Itzhak Ofek ◽  
David L. Hasty
Keyword(s):  
Interleukin 6 ◽  
Lipoteichoic Acid ◽  
Toll Like Receptors ◽  
First Results ◽  
Macrophage Stimulation ◽  
Additional Stimulation

ABSTRACT Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases of interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA plus Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

scholarly journals Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulation

2011 ◽  
Vol 82 (9) ◽  
pp. 1175-1185 ◽  
Author(s):  
Jing Sun ◽  
Liang-Chuan S. Wang ◽  
Zvi G. Fridlender ◽  
Veena Kapoor ◽  
Guanjun Cheng ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Macrophage Stimulation

Effect of macrophage stimulation on parasympathetic airway contraction in dogs

1987 ◽  
Vol 138 (3) ◽  
pp. 421-425 ◽  
Author(s):  
Jun Tamaoki ◽  
Kiyohisa Sekizawa ◽  
Iris F. Ueki ◽  
Paul D. Graf ◽  
Jay A. Nadel ◽  
...  
Keyword(s):  
Macrophage Stimulation
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