Antigen-Specific T Cell Helper Factor: Perspective and Prospect

2015 ◽  
pp. 316-323
Author(s):  
Michael J. Taussig
Keyword(s):  
T Cell ◽  
Helper Factor

Characteristics of a poly(LTyr,LGlu)-poly(DLAla)–poly(LLys)-specific helper factor derived from a T cell hybridoma

1981 ◽  
Vol 11 (11) ◽  
pp. 931-936 ◽  
Author(s):  
Ron N. Apte ◽  
Zelig Eshhar ◽  
Ilana Löwy ◽  
Heidy Zinger ◽  
Edna Mozes
Keyword(s):  
T Cell ◽  
Helper Factor

ANTIGEN-SPECIFIC HELPER FACTOR REACTS WITH ANTIBODY TO THE T-CELL RECEPTOR

1987 ◽  
Vol 14 (2-3) ◽  
pp. 103-107 ◽  
Author(s):  
J. P. Deans ◽  
J. F. Krowka ◽  
T. Mosmannt ◽  
L. M. Pilarski
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Helper Factor

scholarly journals A human T cell lymphoma secreting an immunoglobulin E specific helper factor.

1985 ◽  
Vol 75 (6) ◽  
pp. 1977-1982 ◽  
Author(s):  
M C Young ◽  
H Harfi ◽  
R Sabbah ◽  
D Y Leung ◽  
R S Geha
Keyword(s):  
T Cell ◽  
Immunoglobulin E ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Human T Cell ◽  
Helper Factor

scholarly journals B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.

1981 ◽  
Vol 154 (5) ◽  
pp. 1681-1693 ◽  
Author(s):  
H J Leibson ◽  
P Marrack ◽  
J W Kappler
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cell ◽  
Interleukin 2 ◽  
Spleen Cells ◽  
Con A ◽  
Direct Role ◽  
Cell Responses ◽  
Helper Factor ◽  
Antibody Secreting Cells

A helper factor(s) distinct from interleukin 2 (IL-2) was shown to be present in the concanavalin A-stimulated supernatant of normal mouse spleen cells (normal Con A Sn). Spleen cells thoroughly depleted of T cells required both IL-2 and this factor to produce antibody-secreting cells in response to sheep erythrocytes, although in the presence of IL-2 and a few T cells the requirement for the factor was less apparent. The factor had an apparent approximately 40,000 mol wt. The factor was found in normal Con A Sn that had been depleted of IL-2 by absorption with IL-2-dependent T cells and was absent from Con A-stimulated supernatants of the IL-2-producing T cell hybridoma, FS6-14.13. These results indicate that multiple helper factors control the B cell response to antigen and that IL-2, in addition to its T cell growth promoting activity, plays a direct role in B cell responses.

T-cell hybridoma bearing heavy chain variable region determinants producing (T,G)-A--L-specific helper factor

Nature ◽  
1980 ◽  
Vol 286 (5770) ◽  
pp. 270-272 ◽  
Author(s):  
Zelig Eshhar ◽  
Ron N. Apte ◽  
Ilana Löwy ◽  
Yinon Ben-Neriah ◽  
David Givol ◽  
...  
Keyword(s):  
T Cell ◽  
Heavy Chain ◽  
Variable Region ◽  
Heavy Chain Variable Region ◽  
Helper Factor

scholarly journals Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.

1977 ◽  
Vol 145 (5) ◽  
pp. 1228-1236 ◽  
Author(s):  
T H Hünig ◽  
A Schimpl ◽  
E Wecker
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Immune Responses ◽  
Keyhole Limpet Hemocyanin ◽  
Spleen Cells ◽  
Protein Antigens ◽  
Helper Factor ◽  
T Cell Help ◽  
Kinetics Of

Spleen cells of dinitrophenyl keyhole limpet hemocyanin (DNPKLH) primed and boosted mice produced a nonantigen-specific helper factor upon in vitro challenge with DNPKLH. This helper factor displays all of the biological characteristics so far described for TRF produced by allogeneic or Concanavalin A stimulation of mouse spleen cells. It restores the primary anti-SRBC response in nude spleen cultures following the same kinetics of action as T-cell-replacing factor (TRF). Conversely, TRF restores the primary in vitro immune response of nude spleen cultures to DNPKLH. TRF also restores the secondary anti-hapten IgG response of T-cell-deprived spleen cell cultures derived from DNPKLH primed and boosted mice. Here the need for carrier specificity is fully overcome. The data therefore suggest that TRF, as a nonantigen-specific maturation signal, is involved in the primary and secondary immune responses to both particulate and soluble antigens.

Characterization of Human CD4+ T-Cell Clones that Secrete Helper Factor(s) for B-Cell Proliferation and Maturation

1988 ◽  
Vol 28 (5) ◽  
pp. 519-527
Author(s):  
T. BERZINS ◽  
M. VARGAS-CORTES ◽  
B. AXELSSON ◽  
M.-L. HAMMARSTROM ◽  
S. HAMMARSTROM ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
T Cell ◽  
B Cell ◽  
Cd4 T Cell ◽  
T Cell Clones ◽  
Cell Clones ◽  
Helper Factor

T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice

Nature ◽  
1980 ◽  
Vol 284 (5753) ◽  
pp. 278-280 ◽  
Author(s):  
Hermann Wagner ◽  
Conny Hardt ◽  
Klaus Heeg ◽  
Martin Röllinghoff ◽  
Klaus Pfizenmaier
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cytotoxic T Cells ◽  
Helper Factor ◽  
In Vivo Induction
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