Structure and Arrangement of Human Heavy Chain Variable Region Genes

2015 ◽  
pp. 132-138
Author(s):  
G. Matthyssens ◽  
T. H. Rabbitts
Keyword(s):  
Heavy Chain ◽  
Variable Region ◽  
Heavy Chain Variable Region ◽  
Variable Region Genes

scholarly journals Interaction and sequence diversity among T15 VH genes in CBA/J mice.

1988 ◽  
Vol 168 (4) ◽  
pp. 1339-1349 ◽  
Author(s):  
S E Ferguson ◽  
S Rudikoff ◽  
B A Osborne
Keyword(s):  
Heavy Chain ◽  
Sequence Variation ◽  
Variable Region ◽  
Gene Interaction ◽  
Time Frame ◽  
Gene Correction ◽  
Heavy Chain Variable Region ◽  
Vh Genes ◽  
Short Time ◽  
Variable Region Genes

Nucleotide sequences of the four genes composing the T15 heavy chain variable region (VH) family of the CBA/J mouse have been determined. Comparison of these sequences with their published BALB/c and C57BL/10 homologues reveals that nucleotide differences found between given alleles of two strains, i.e., CBA/J and BALB/c, are observed in other family members of the same strain. We suggest that these patterns of sequence variation are most readily explained by gene interaction (conversion). Additionally, the sequence of a CBA/J hybridoma, 6G6, proposed to have been generated by gene conversion, is directly encoded by the CBA/J V11 gene indicating that the putative conversion has occurred meiotically in the germline. These results are consistent with the premise that gene correction is occurring frequently among members of this family and that such processes may contribute significantly to the evolution of Ig variable region genes even in the relatively short time frame of inbred strain derivation.

The heavy chain variable region genes of human lupus autoantibodies

1994 ◽  
pp. 131-149
Author(s):  
Christophe Demaison ◽  
Patricia Chastagner ◽  
Céline Bensimon ◽  
Moncef Zouali
Keyword(s):  
Heavy Chain ◽  
Variable Region ◽  
Heavy Chain Variable Region ◽  
Variable Region Genes
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