Mechanical Factors in Intrahepatic Cholestasis: Reversible and Irreversible

2015 ◽  
pp. 42-46
Author(s):  
D. S. Zimmon
Keyword(s):  
Intrahepatic Cholestasis ◽  
Mechanical Factors

Control of Cellular Morphology by Mechanical Factors

1996 ◽  
Vol 6 (11) ◽  
pp. 1555-1566 ◽  
Author(s):  
Olivier Thoumine
Keyword(s):  
Cellular Morphology ◽  
Mechanical Factors

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites downregulate hepatic LXR[a]

2013 ◽  
pp. 1-1
Author(s):  
Vanya Nikolova ◽  
Shadi Abu Hayyeh ◽  
Georgia Papacleovoulou ◽  
Malcolm Parker ◽  
Catherine Williamson
Keyword(s):  
Intrahepatic Cholestasis ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Progesterone Metabolites ◽  
Cholestasis Of Pregnancy

Recovery from LCDD-associated Severe Liver Cholestasis: a Case Report and Literature Review

2016 ◽  
Vol 25 (1) ◽  
pp. 99-103 ◽  
Author(s):  
Benoit Brilland ◽  
Johnny Sayegh ◽  
Anne Croue ◽  
Frank Bridoux ◽  
Jean-François Subra ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Intrahepatic Cholestasis ◽  
Relevant Literature ◽  
Gamma Glutamyl Transferase ◽  
Light Chain Deposition Disease ◽  
Deposition Disease ◽  
Uncommon Presentation ◽  
Light Chain Deposition ◽  
Glutamyl Transferase

Light chain deposition disease (LCDD) is a rare multisystemic disorder associated with plasma cell proliferation. It mainly affects the kidney, but liver and heart involvement may occur, sometimes mimicking the picture of systemic amyloidosis. Liver disease in LCDD is usually asymptomatic and exceptionally manifests with severe cholestatic hepatitis. We report the case of a 66-year-old female with κ-LCDD and cast nephropathy in the setting of symptomatic multiple myeloma who, after a first cycle of bortezomib-dexamethasone chemotherapy, developed severe and rapidly worsening intrahepatic cholestasis secondary to liver κ-light chain deposition. Intrahepatic cholestasis was attributed to LCDD on the basis of the liver histology and exclusion of possible diagnoses. Chemotherapy was maintained and resulted in progressive resolution of cholestasis. We report here an uncommon presentation of LCDD, with prominent liver involvement that fully recovered with bortezomib-based chemotherapy, and briefly review the relevant literature. Abbreviations: AKI: Acute kidney injury; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate aminotransferase; CMV: Cytomegalovirus; EBV: Epstein–Barr virus; GGT: gamma-glutamyl transferase; HSV: Herpes simplex virus; LC: light chain; LCDD: Light chain deposition disease; MIDD: Monoclonal immunoglobulin deposition disease; MM: Multiple myeloma.

Mechanical Factors of Infl uence on Biological Effi ciency of Solanum Nigrum L.

2014 ◽  
Vol 1 (2) ◽  
pp. 20-23
Author(s):  
O. Ivashchenko ◽  
O. Ivashchenko
Keyword(s):  
Solanum Nigrum ◽  
Black Nightshade ◽  
Effi Ciency ◽  
Weed Plants ◽  
Sensitivity Level ◽  
Solanum Nigrum L ◽  
Small Plot ◽  
Mechanical Factors ◽  
The Moment ◽  
Working Out

Aim. Studying of black nightshade young plants’ response to the induced mechanical stresses. Methods. Researches conducted in small plot fi eld experiments. Results. Change of sensitivity level of Solanum nigrum L. plants depending on phases of their development at the moment of damage of elevated parts has been proven. Owing to loss of the surface capable to photosynthesis, there is an essential decrease in volumes of photosynthesis at plants of weed survived and their possibilities of ontogeny passage. The deep induced dis- stresses reduce biological effi ciency of plants, their ability to accumulate weight and to form seeds and even lead them to death. Conclusions. The defi ned principles of response of weed plants to the induced mechanical dis-stresses are can be used for working out and ecological receptions of crops protection from weeds.

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