Congenital Malformations Causing Renal Failure in the Neonatal Period

2015 ◽  
pp. 55-66 ◽  
Author(s):  
Wallace W. McCrory
Keyword(s):  
Renal Failure ◽  
Congenital Malformations ◽  
Neonatal Period

Oligohydramnion in the First Half of Pregnancy in the Fetuses with Congenital Abnormalities: Ultrasound Diagnostics and Obstetric Outcomes

2021 ◽  
Vol 76 (4) ◽  
pp. 341-350
Author(s):  
Sergey M. Voevodin ◽  
Tatiana V. Shemanaeva ◽  
Alyona V. Serova
Keyword(s):  
Amniotic Fluid ◽  
Congenital Malformations ◽  
Fetal Death ◽  
Congenital Abnormalities ◽  
Neonatal Period ◽  
Perinatal Outcomes ◽  
Main Group ◽  
Obstetric Outcomes ◽  
Fetal Abnormalities ◽  
4D Ultrasound

Background.Oligohydramnion in the first half of pregnancy, combined with congenital abnormalities in the fetus has objective difficulties in diagnosis. The morphology features and type of defects associated with oligohydramnion, which manifests in the first half of pregnancy, are not sufficiently studied at the present stage. Aims to evaluate the clinical significance of diagnosing oligohydramnion in the first half of pregnancy in women with congenital fetal malformations. Materials and methods.The analysis of the course of pregnancy and perinatal outcomes in 77 women with low water content in combination with congenital malformations of the fetus and 72 patients with a normal amount of amniotic fluid and no congenital malformations of the fetus was performed. The patients of the main group were divided into two subgroups depending on the severity of oligohydramnion: the 1st subgroup (n = 54) patients with severe oligohydramnion and the 2nd subgroup (n = 23) patients with moderate oligohydramnion. The amount of amniotic fluid was determined by 3D/4D ultrasound (1321 weeks of gestation) and the structure of fetal abnormalities associated with oligohydramnion was analyzed. We evaluated perinatal outcomes in women with congenital malformations of the fetus in combination with oligohydramnion and the effect of its severity on the outcome of pregnancy. Results.In the main group (n = 77), fetal abnormalities were detected in patients: urinary system 39 (50.6%), respiratory system 4 (5.2%), heart 1 (1.3%), chromosomal and genetic abnormalities 14 (18.2%), central nervous system 3 (3.9%), osseous system 3 (3.9%), multiple 13 (16.9%). In the main group (n = 77), pregnancy was terminated for medical indications in 47 (61%) cases, in 6 (7.8%) spontaneous miscarriage occurred, in 5 (6.5%) antenatal fetal death. 19 (24.7%) children were born alive, and surgical treatment in the neonatal period was required in 8 (10.4%) cases. In the 1st subgroup (n = 54) in 53 (98.1%) cases, there was a loss of the fetus, in 1 (1.9%) the newborn died on the 9th day. In the 2nd subgroup (n = 23), fetal death occurred in 5 (21.7%) cases, 18 (78.3%) children were born alive, and 8 (44.4%) newborns were operated on in the neonatal period. In the control group, all pregnancies ended with the birth of healthy children. A decrease in ultrasound imaging of internal organs in the fetus was observed when a pregnant woman was obese (BMI more than 35). Conclusions.Oligohydramnion in the first half of pregnancy in combination with fetal malformation should be considered an extremely unfavorable clinical sign for the prognosis of pregnancy and the health of the fetus and newborn. 3D/4D ultrasound scanning allows you to reliably determine oligohydramnion in the first half of pregnancy, and the degree of its severity to assume the nature of complications.

Exome sequencing in the assessment of congenital malformations in the fetus and neonate

2019 ◽  
pp. fetalneonatal-2018-316352 ◽  
Author(s):  
Fionnuala Mone ◽  
Elizabeth Quinlan-Jones ◽  
Andrew K Ewer ◽  
Mark D Kilby
Keyword(s):  
Next Generation Sequencing ◽  
Exome Sequencing ◽  
Congenital Malformations ◽  
Neonatal Period ◽  
Diagnostic Yield ◽  
Prolonged Hospitalisation ◽  
Pathogenic Variants ◽  
Fetus And Neonate ◽  
Generation Sequencing

Major congenital anomalies are often associated with perinatal mortality, long-term morbidity and prolonged hospitalisation. Prenatal ultrasound remains the principle diagnostic test for many anomalies, but despite this up to one-third are only identified in the neonatal period. The primary step in determining underlying aetiology is to define accurately the phenotype by recognition of dysmorphology (both prenatally and postnatally). The potential introduction of next-generation sequencing, primarily through exome sequencing, into perinatal practice may improve the pathological diagnostic yield. However, clinicians must understand both the benefit and potential harms of this technology in facilitating the discovery of relevant pathogenic variants in the diagnosis and management of congenital malformations.

scholarly journals CLINICAL AND THERAPEUTIC ASPECTS IN THE SEVERE AORTIC COARCTATION WITH DUCT DEPENDENT SYSTEMIC CIRCULATION IN THE NEWBORN

2015 ◽  
Vol 64 (4) ◽  
pp. 406-409
Author(s):  
Alina-Costina Luca ◽  
◽  
Andreea-Simona Holoc ◽  
Constantin Iordache ◽  
◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Response ◽  
Early Treatment ◽  
Aortic Coarctation ◽  
Congenital Malformations ◽  
Prostaglandin E1 ◽  
Clinical Case ◽  
Neonatal Period ◽  
Systemic Circulation ◽  
Early Diagnostic

The aortic coarctation has an incidence of 0.6-0.8/1,000 newborn, with clinical manifestation starting with the neonatal period. In the newborn, the heart congenital malformations associated to heart failure and clinical response early in the first hours of life have a guarded prognosis, needing an early diagnostic and an adequate therapeutic conduct. We present a clinical case of severe aortic coarctation with duct dependent systemic circulation, diagnosed early in the neonatal period. The early treatment with Prostaglandin E1 allowed the maintenance of the hemodynamic balance, the newborn benefiting from surgical correction in the first month of life.

Congenital Malformations Presenting During the Neonatal Period

1998 ◽  
Vol 25 (2) ◽  
pp. 351-369 ◽  
Author(s):  
Julie Kessel ◽  
Robert M. Ward
Keyword(s):  
Congenital Malformations ◽  
Neonatal Period

scholarly journals Mortality among children under the age of one: analysis of cases after discharge from maternity *

2016 ◽  
Vol 50 (3) ◽  
pp. 390-398 ◽  
Author(s):  
Elieni Paula dos Santos ◽  
Rosângela Aparecida Pimenta Ferrari ◽  
Maria Rita Bertolozzi ◽  
Alexandrina Aparecida Maciel Cardelli ◽  
Christine Bacarat de Godoy ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Causes Of Death ◽  
Neonatal Period ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Medical Visits ◽  
Time Period ◽  
Chi Square Test ◽  
External Causes

Abstract OBJECTIVE To analyze infant death after discharge from maternity in the time period between 2000 and 2013. METHOD A cross-sectional retrospective quantitative study in a municipality northward in the state of Paraná. Data were analyzed using the SPSS®, and were subjected to Chi-square test, logistical regression, 95% confidence interval, and a significance level of p <0.05. RESULTS Two hundred forty-nine children were born, discharged from maternity and subsequently died; 10.1% in the neonatal period and 89.9% in the post-neonatal period. Pregnancy follow-up, birth, and child monitoring took place mainly in the public health system. There was a statistically significant association between the infant component and place of delivery (p =0.002; RR=1.143; IC95%=1.064-1.229), and a lower number of childcare medical visits (p =0.001; RR=1.294; IC95%=1.039-1.613). The causes of death in the neonatal period were perinatal conditions (40%); external causes (32%); and congenital malformations (20%). In the post-neonatal period, congenital malformations (29.9%), external causes (24.1%); and infectious-parasitic diseases (11.2%) were the causes of death. CONCLUSION Virtually all children were born in conditions of good vitality that were worsened due to potentially preventable diseases that led to death.

Inherited and Congenital Malformations of the Kidneys in the Neonatal Period

1992 ◽  
Vol 19 (1) ◽  
pp. 197-211 ◽  
Author(s):  
Bernard S. Kaplan ◽  
Paige Kaplan ◽  
Eduardo Ruchelli
Keyword(s):  
Congenital Malformations ◽  
Neonatal Period

scholarly journals STRUCTURE OF SURGICAL ABNORMALITY IN NEWBORNS OF THE NIZHNY NOVGOROD REGION

2019 ◽  
Vol 8 (4) ◽  
pp. 33-38
Author(s):  
I. Yu. Karpova ◽  
V. V. Parshikov ◽  
E. A. Rozhdenkin ◽  
G. B. Batanov ◽  
V. E. Pivikov ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Birth Rate ◽  
Congenital Abnormalities ◽  
Neonatal Period ◽  
Initial Therapy ◽  
Surgical Pathology ◽  
Adequate Treatment ◽  
Medical University ◽  
The City ◽  
Nizhny Novgorod Region

Introduction.A tendency to the decline in birth rate and reduced number of diseases of the neonatal period has been lately observed in the Nizhny Novgorod region.Materials and methods. 494 neonates with a surgical pathology aged from the frst hours to several weeks were treated in hospitals serving as clinical bases for the Volga Research Medical University from 2013 to 2017. 305 (62%) boys and 189 (38%) girls were observed. The majority of children (88%) were taken to surgical departments from maternity homes and perinatal centers of the city and region. 62 (12%) of children were hospitalized following the referral from local pediatricians. Admitted patients had a clinical and instrumental examination and initial therapy that stabilized their conditions and prepared them for surgeries.Results. Congenital malformations (CM) were diagnosed in 330 (67%) children only. According to analysis of diseases related to the neonatal period, purulent and septic processes were found in 104 (21%) patients. Surgeries were performed in children aged from day 1 to several months of life.Conclusion. Modern antenatal diagnostics and complex examination of newborns in the neonatal period enable timely detection of congenital abnormalities and initiation of adequate treatment.

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