The Phosphate-Depletion Syndrome

2015 ◽  
pp. 162-174 ◽  
Author(s):  
Wilhelm Kreusser ◽  
Eberhard Ritz
Keyword(s):  
Phosphate Depletion

Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins

1990 ◽  
Vol 258 (6) ◽  
pp. F1640-F1649
Author(s):  
E. Bellorin-Font ◽  
R. Starosta ◽  
C. L. Milanes ◽  
C. Lopez ◽  
N. Pernalete ◽  
...  
Keyword(s):  
Metabolic Acidosis ◽  
Adenylate Cyclase ◽  
Maximal Activity ◽  
Phosphate Deprivation ◽  
Adp Ribosylation ◽  
Phosphate Depletion ◽  
Cortical Membranes ◽  
And Function ◽  
Gs Alpha

These studies examine the regulation of adenylate cyclase in renal cortical membranes from phosphate-deprived and phosphate-deprived acidotic dogs. Enzyme stimulation by parathyroid hormone (PTH) was decreased in phosphate deprivation [Vmax 1,578 +/- 169 vs. 2,581 +/- 219 pmol adenosine 3',5'-cyclic monophosphate (cAMP).mg protein-1 x 30 min-1 in controls, P less than 0.01]. Metabolic acidosis further decreased PTH-stimulated activity. Membranes from phosphate-deprived dogs showed a decrease in Gs alpha-content by cholera toxin-dependent ADP-ribosylation (174 +/- 18 arbitrary units vs. 266.4 +/- 13.6 in controls, P less than 0.01). Metabolic acidosis further decreased Gs alpha-content, P less than 0.01. Gi content by pertussis-dependent ADP-ribosylation was also lower in phosphate-deprived and phosphate-deprived acidotic animals. Gs function was examined by its property to protect the catalytic unit from inactivation by N-ethylmaleimide when preincubated with GTP gamma S. In controls, protection of inactivation was 80% of the maximal activity, whereas in phosphate deprivation protection was less than 50%. In conclusion, metabolic acidosis enhances adenylate cyclase resistance to PTH in phosphate deprivation. These alterations are associated with a decrease in the content and function of Gs alpha, suggesting a role of Gs in the renal adaptation to phosphate depletion and acidosis.

scholarly journals 636 MECHANISMS FOR SEX DIFFERENCES IN ANTACID-INDUCED PHOSPHATE DEPLETION

1981 ◽  
Vol 15 ◽  
pp. 546-546
Author(s):  
Kathleen B Schwarz ◽  
Debra C Zimmerman ◽  
Max Zahn ◽  
David H Alpers ◽  
Louis V Avioli ◽  
...  
Keyword(s):  
Sex Differences ◽  
Phosphate Depletion

Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle

1983 ◽  
Vol 245 (1) ◽  
pp. C15-C20 ◽  
Author(s):  
K. Sahlin ◽  
L. Edstrom ◽  
H. Sjoholm
Keyword(s):  
High Energy ◽  
Initial Value ◽  
High Co2 ◽  
Fourfold Increase ◽  
Control Value ◽  
Before And After ◽  
Phosphate Depletion ◽  
Creatine Kinase Equilibrium ◽  
Lactate And Pyruvate ◽  
Tetanic Tension

Isolated extensor digitorum longus muscles from rat were exposed to atmospheres of 30% CO2 (high-CO2 muscles) or 6.5% CO2 (control muscles) in O2 for 95 min. Muscle contraction characteristics were studied before and after the incubation. Tetanic tension decreased in high-CO2 muscles to 55% of initial value but remained unchanged in control muscles. Relaxation time was prolonged in high-CO2 muscles but not in control muscles. Intracellular pH was 6.67 +/- 0.04 (SD) in high-CO2 muscles and 7.01 +/- 0.04 in control muscles. CO2-induced acidosis had a marked influence on the intermediary energy metabolism as shown by a fourfold increase of glucose 6-phosphate, a 14% increase of ADP, and a decrease of phosphocreatine to 44% of the control value. Lactate and pyruvate contents were unchanged. The observed metabolic changes can be explained by an effect of H+ on the activity of phosphofructokinase and on the creatine kinase equilibrium. It can be concluded that H+ concentration causes muscular fatigue. It is, however, uncertain whether this is an effect of increased H+ per se or by high-energy phosphate depletion induced by acidosis.

Proteogenomics of a saxitoxin-producing and non-toxic strain ofAnabaena circinalis(cyanobacteria) in response to extracellular NaCl and phosphate depletion

2016 ◽  
Vol 18 (2) ◽  
pp. 461-476 ◽  
Author(s):  
Paul M. D'Agostino ◽  
Xiaomin Song ◽  
Brett A. Neilan ◽  
Michelle C. Moffitt
Keyword(s):  
Phosphate Depletion

High energy phosphate depletion in leaflet matrix cells during processing of cryopreserved cardiac valves

1992 ◽  
Vol 52 (5) ◽  
pp. 483-488 ◽  
Author(s):  
Robert H. Messier ◽  
Patrick W. Domkowski ◽  
Hamdy M. Aly ◽  
Anwar S. Abd-Elfattah ◽  
Donald G. Crescenzo ◽  
...  
Keyword(s):  
High Energy ◽  
High Energy Phosphate ◽  
Cardiac Valves ◽  
Phosphate Depletion
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