Normovolemic and Hypervolemic Hemodilution in Cerebrovascular Ischemia

2015 ◽  
pp. 127-138 ◽  
Author(s):  
Ulrich Gottstein
Keyword(s):  
Hypervolemic Hemodilution

THE PROTECTIVE EFFECT OF HYPERVOLEMIC HEMODILUTION IN EXPERIMENTAL HEATSTROKE

Shock ◽  
2001 ◽  
Vol 16 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Chen-Kuei Chang ◽  
Cheu-Heng Chien ◽  
Hung-Li Chou ◽  
Mao-Tsun Lin
Keyword(s):  
Protective Effect ◽  
Hypervolemic Hemodilution

scholarly journals Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Marion Bienert ◽  
Niklas Plange ◽  
Andreas Remky ◽  
Kay Oliver Arend ◽  
David Kuerten
Keyword(s):  
Blood Flow ◽  
Hydroxyethyl Starch ◽  
Optic Neuropathy ◽  
Acute Effect ◽  
Anterior Ischemic Optic Neuropathy ◽  
Ischemic Optic Neuropathy ◽  
Hypervolemic Hemodilution ◽  
Blood Flow Velocities ◽  
Retrobulbar Hemodynamics ◽  
Flow Velocities

Purpose.Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION).Methods.24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot’s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs).Results.After infusion of HES blood flow velocities significantly increased in the CRA (PSV from7.53±2.33to8.32±2.51  (p<0.001); EDV from2.16±0.56to2.34±0.55  (p<0.05)) and in the PCAs (PSV from7.18±1.62to7.56±1.55  (p<0.01); EDV from2.48±0.55to2.66±0.6 cm/sec (p<0.01)). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged.Conclusions.Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered withDRKS00012603.

Hypervolemic-Hemodilution During Cerebral Ischemia in Rats

1997 ◽  
Vol 9 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Daniel J. Cole ◽  
John C. Drummond ◽  
Piyush M. Patel ◽  
Lowell R. Reynolds
Keyword(s):  
Cerebral Ischemia ◽  
Hypervolemic Hemodilution

Hypervolemic hemodilution in experimental focal cerebral ischemia

1983 ◽  
Vol 59 (3) ◽  
pp. 500-509 ◽  
Author(s):  
James H. Wood ◽  
Frederick A. Simeone ◽  
Eugene A. Fink ◽  
Michael A. Golden
Keyword(s):  
Molecular Weight ◽  
Focal Cerebral Ischemia ◽  
Arterial Occlusion ◽  
Total Blood ◽  
Content Type ◽  
Arterial Blood ◽  
Hypervolemic Hemodilution ◽  
The Mean ◽  
Cerebral Arterial Occlusion ◽  
Hemispheric Infarction

✓ Cerebrovascular and cardiac alterations evoked by intravascular volume expansion with low molecular weight dextran (LMD, molecular weight 40,000), an advocated adjunct in the clinical prevention or therapy of acute stroke and cerebral vasospasm, were studied in splenectomized dogs. Clipping of the right distal internal carotid artery and the proximal middle cerebral artery (MCA) in eight dogs decreased regional cortical blood flow (rCoBF) by 58% without changing cardiac output (CO), and caused 10% ± 5% (SE) hemispheric infarction. Ten other dogs underwent similar cerebral arterial occlusion and were infused twice with LMD within 2 hours; each infusion equaled 20% of the respective dog's total blood volume. Both CO and rCoBF in the territory of the occluded MCA increased significantly by 119% ± 13% and 42% ± 6%, respectively, following the two LMD infusions. Although the mean arterial blood pressure was unaltered, the hematocrit decreased significantly and the intracranial pressure (ICP) increased significantly. The mean hemispheric infarction in these 10 treated dogs was 4% ± 2%. Another nine dogs underwent arterial manipulation without clipping. Two hemodiluting LMD infusions, similar to those in the 10 dogs, significantly elevated CO and ICP but not rCoBF. These data suggest that hypervolemic hemodilution with LMD effectively elevates collateral perfusion to ischemic regions of brain distal to occluded MCA segments and concomitantly raises the CO and ICP.

scholarly journals Simultaneous investigations of maternal cardiac output and fetal blood flow during hypervolemic hemodilution in preeclampsia — preliminary observations

1986 ◽  
Vol 14 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Ulrich Siekmann ◽  
Lothar Heilmann ◽  
Wolfgang Klosa ◽  
Ludwig Quaas ◽  
Helmut Schillinger
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Fetal Blood ◽  
Hypervolemic Hemodilution

Comparison of hypervolemic hemodilution concepts in acute stroke

1996 ◽  
Vol 16 (3) ◽  
pp. 367-375
Author(s):  
Johannes Treib ◽  
Anton Haass ◽  
Markus T. Grauer ◽  
Martin Stoll ◽  
Dagmar Koch ◽  
...  
Keyword(s):  
Acute Stroke ◽  
Hypervolemic Hemodilution
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