Aplastic Anaemia: Clinical Course and Histologic Picture

2015 ◽  
pp. 103-108
Author(s):  
P. Meusers ◽  
E. K�nig ◽  
G. Brittinger
Keyword(s):  
Aplastic Anaemia ◽  
Clinical Course

scholarly journals Necrotizing Bacterial Myositis as the Initial Presentation of Severe Aplastic Anaemia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Synne Dragesund Rørvik ◽  
Kristoffer Stange Larsen ◽  
Lars Helgeland ◽  
Håvard Dale ◽  
Birgitta Ivarsen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Soft Tissue ◽  
Aplastic Anaemia ◽  
Clinical Course ◽  
Initial Presentation ◽  
Severe Neutropenia ◽  
Soft Tissue Infections ◽  
Severe Aplastic Anaemia ◽  
Necrotizing Soft Tissue Infections ◽  
Severe Pancytopenia

Introduction. Necrotizing soft tissue infections are rapidly progressing infections associated with severe inflammation and cytokine release. Early recognition and surgical intervention are key factors to secure survival. The current case presents a patient with multifocal necrotizing soft tissue infection as the initial presentation of severe aplastic anaemia. Case Presentation. A man in his fifties was admitted with septic shock with multiorgan failure and severe pancytopenia, after two days of malaise with high fever and right flank pain. The diagnosis streptococcal necrotizing myositis was significantly delayed due to atypical clinical findings. After initial surgical exploration, the decision was made to defer from surgical debridement due to extensive involvement of several muscle groups, grave pancytopenia, and suspected dismal prognosis. Surprisingly, the patient stabilized after antibiotics and intensive care treatment. Based on severe pancytopenia and hypocellular bone marrow, with no evidence of other bone marrow disorders, the patient was diagnosed with aplastic anaemia. Treatment for aplastic anaemia with antithymocyte globulin, cyclosporine, and eltrombopaq was started, and 2 months later, a partial haematological recovery was observed. The patient could be discharged from hospital without antibiotic treatment. Conclusions. This case illustrates the crucial role of a multidisciplinary approach on admission and further during the clinical course. Clinical improvement despite severe neutropenia and stabilization during immunosuppressive therapy suggest that immunological factors modulate clinical course in necrotizing soft tissue infections.

scholarly journals Detection of GPI-anchored protein-deficient cells in patients with aplastic anaemia and evidence for clonal expansion during the clinical course

1999 ◽  
Vol 105 (1) ◽  
pp. 80-84 ◽  
Author(s):  
Kohtaro Kawaguchi ◽  
Hiroshi Wada ◽  
Ako Mori ◽  
Yoshinobu Takemoto ◽  
Eizo Kakishita ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Clinical Course ◽  
Clonal Expansion

Aplastic anaemia during pregnancy: variable clinical course and outcome

2001 ◽  
Vol 94 (1) ◽  
pp. 152-154 ◽  
Author(s):  
Deepika Deka ◽  
Neelam Banerjee ◽  
Kallol K. Roy ◽  
V.P. Choudhary ◽  
Rajesh Kashyap ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Clinical Course

74: How Septic is Urosepsis? Treatment and Clinical Course of Infected Hydronephrosis

2005 ◽  
Vol 173 (4S) ◽  
pp. 21-21
Author(s):  
Frank Christoph ◽  
Steffen Weikert ◽  
Markus Müller ◽  
Kurt Miller
Keyword(s):  
Clinical Course ◽  
Infected Hydronephrosis
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