Rapid Induction of Epithelial Hyperplasia and Lymphoplasmacytosis in the Chinese Hamster (Cricetulus griseus) by Mineral and Pristane Oil1

2015 ◽  
pp. 424-434 ◽  
Author(s):  
G. Yerganian ◽  
I. Paika ◽  
H. J. Gagnon ◽  
A. Battaglino
Keyword(s):  
Chinese Hamster ◽  
Cricetulus Griseus ◽  
Epithelial Hyperplasia ◽  
Rapid Induction

Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia

1989 ◽  
Vol 9 (1) ◽  
pp. 6-14
Author(s):  
S J Compere ◽  
P A Baldacci ◽  
A H Sharpe ◽  
R Jaenisch
Keyword(s):  
Rapid Development ◽  
Latency Period ◽  
Mouse Embryos ◽  
Epithelial Hyperplasia ◽  
Ras Oncogene ◽  
Cutaneous Lesions ◽  
Retroviral Transduction ◽  
Rapid Induction ◽  
Time Of Infection ◽  
Adult Skin

Infection of mouse embryos at 8 days of gestation with a replication-defective retrovirus carrying the human c-Ha-ras-1 oncogene led to efficient and rapid induction of hyperplastic lesions. Twenty-four percent of viable off-spring developed abnormal growths after infection with purified virus. The lesions contained a single integrated provirus and produced viral RNA and the Ha-ras oncogene product (p21). The latency period between the time of infection and appearance of the lesions suggested that secondary alterations in addition to activated ras were necessary for neoplasms to develop. The earliest and most abundant growths were cutaneous and appeared from 4 to 36 weeks of age, with a median of 4 weeks of age. A number of subcutaneous lesions also developed over the same time span but at a median of 18 weeks of age. The rapid development of cutaneous lesions in response to transduction of the ras oncogene contrasts with other studies in which adult skin required secondary treatment with promoters prior to ras induction of epithelial hyperplasia. These results demonstrate that infection of midgestation mouse embryos allows rapid analysis of oncogene potency in skin.

Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation

1988 ◽  
Vol 8 (11) ◽  
pp. 4716-4720
Author(s):  
A J Fornace ◽  
H Schalch ◽  
I Alamo
Keyword(s):  
Sequence Analysis ◽  
Uv Irradiation ◽  
Time Course ◽  
Human Fibroblasts ◽  
Chinese Hamster ◽  
Cdna Clones ◽  
X Rays ◽  
General Stress Response ◽  
Rapid Induction ◽  
Kinetics Of

Sequence analysis of Chinese hamster V79 lung fibroblast cDNA clones, which code for UV radiation-inducible transcripts, revealed that many of the clones corresponded to metallothioneins (MTs) I and II. A third cDNA clone, DDIU4, was found also to code for a similar-size UV-inducible transcript which was unrelated to MT by both sequence analysis and kinetics of induction. MTI and MTII RNAs rapidly increased in V79 cells within 1 h after UV irradiation, and maximum induction was seen by 4 h. This rapid induction of MT RNA by UV irradiation was not observed in human fibroblasts. MTI and MTII were coordinately induced in both time course and dose-response experiments, although the induction of MTII, up to 30-fold, was three to four times greater than that of MTI. The induction of MT did not appear to be a general stress response, since no increase occurred after exposure to X rays or H2O2.

scholarly journals Fine Structure of the Parotid Gland of Chinese Hamster (Cricetulus griseus)

1981 ◽  
Vol 30 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Syusaku SUZUKI ◽  
Hayao NISHINAKAGAWA ◽  
Junichi OTSUKA
Keyword(s):  
Fine Structure ◽  
Parotid Gland ◽  
Chinese Hamster ◽  
Cricetulus Griseus
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