Sudden Coronary Death: Incidence and Common Risk Factors

Author(s):  
M. Romo ◽  
R. Ruosteenoja
Circulation ◽  
1998 ◽  
Vol 97 (21) ◽  
pp. 2110-2116 ◽  
Author(s):  
Allen P. Burke ◽  
Andrew Farb ◽  
Gray T. Malcom ◽  
You-hui Liang ◽  
John Smialek ◽  
...  

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Eduardo Missel ◽  
Gary S Mintz ◽  
Stephane G Carlier ◽  
Jie Qian ◽  
Shoujie Shan ◽  
...  

Background: Histopathological data shows that cigarette smoking and a total-cholesterol-to-high-density-lipoprotein ratio (TC/HDL) >5 are associated to sudden coronary death (SCD) in men. We hypothesized a relationship between virtual histology intravascular ultrasound (VH-IVUS) findings and these risk factors. Methods and Results: We performed whole pullback VH-IVUS analyses in a consecutive series of 473 male pts and measured the four basic VH-IVUS coronary plaque components - fibrous (FI), fibro-fatty (FF), dense calcium (DC) and necrotic core (NC) - as well as calculated a NC/DC ratio. Pts age was 61±11years, with 27% current smokers and 69% with a lipid disorder. Among VH-IVUS parameters, the NC/DC ratio was the only parameter related both to the TC/HDL ratio (r=0.18, p=0.0008) and LDL-C levels (r=0.17, p=0.002); it had a negative correlation with HDL-C levels (r=0.11, p=0.03), and was significantly higher for smokers [median: 1.98 (1.35, 3.18)] vs. non-smokers [median: 1.70 (1.23, 2.53), p=0.006]. A NC/DC value >3 was the threshold that best identified smokers with a TC/HDL>5 (odds ratio 3.0, p=0.0001). ROC curves showed superiority of the NC/DC ratio (A 2 : 0.64, p<0.0001) over %DC (A 2 : 0.58, p=0.006) or %NC (A 2 : 0.51, p=0.43) as isolate parameters to identify pts with a risk profile for SCD (Figure ). Conclusions: In diseased coronary segments the ratio of necrotic core to calcification detected by VH-IVUS is related to previously-published pathologic risk factors for SCD.


Circulation ◽  
2002 ◽  
Vol 105 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Allen P. Burke ◽  
Andrew Farb ◽  
Joseph Pestaner ◽  
Gray T. Malcom ◽  
Arthur Zieske ◽  
...  

Author(s):  
Hiroyoshi Mori ◽  
Sho Torii ◽  
Renu Virmani

Despite improvement in the treatment, prevention, and risk factor management of atherosclerosis, the most frequent cause of death globally remains coronary artery disease. Therefore, it is essential to understand the underlying mechanisms involved in the manifestation of acute coronary syndromes, sudden cardiac death, or stable ischaemic heart disease. Coronary atherothrombosis is the main underlying cause of acute coronary syndromes. This chapter discusses the two most frequent causes of atherothrombosis, that is, plaque rupture and plaque erosion, in patients presenting with acute myocardial infarction or sudden coronary death, including differences in the incidence, aetiology, morphological features, and risk factors that lead to plaque rupture and erosion.


Epidemiology ◽  
1997 ◽  
Vol 8 (2) ◽  
pp. 175-180 ◽  
Author(s):  
Luis G. Escobedo ◽  
Carl J. Caspersen

2009 ◽  
Vol 223 (1) ◽  
pp. 19-25 ◽  
Author(s):  
OLLI SUHONEN ◽  
ANTTI REUNANEN ◽  
PAUL KNEKT ◽  
ARPO AROMAA

Sign in / Sign up

Export Citation Format

Share Document