Juxta-Cerebroventricular Sodium Sensitivity

2015 ◽  
pp. 107-118
Author(s):  
B. Andersson
Keyword(s):  
Hypertension ◽  
1996 ◽  
Vol 28 (1) ◽  
pp. 139-142 ◽  
Author(s):  
Takashi Uzu ◽  
Frida S. Kazembe ◽  
Kazuhiko Ishikawa ◽  
Satoko Nakamura ◽  
Takashi Inenaga ◽  
...  

1988 ◽  
Vol 6 (4) ◽  
pp. S209-212 ◽  
Author(s):  
Akira Sakaguchi ◽  
Toshihiro Saito ◽  
Kazutoshi Yamamoto ◽  
Jiro Iwata ◽  
Masahide Tonooka ◽  
...  

Author(s):  
Jiang He ◽  
Jian-Feng Huang ◽  
Changwei Li ◽  
Jing Chen ◽  
Xiangfeng Lu ◽  
...  

Cross-sectional studies have reported that high sodium sensitivity is more common among individuals with hypertension. Experimental studies have also reported various animal models with sodium-resistant hypertension. It is unknown, however, whether sodium sensitivity and resistance precede the development of hypertension. We conducted a feeding study, including a 7-day low-sodium diet (1180 mg/day) followed by a 7-day high-sodium diet (7081 mg/day), among 1718 Chinese adults with blood pressure (BP) <140/90 mm Hg. We longitudinally followed them over an average of 7.4 years. Three BP measurements and 24-hour urinary sodium excretion were obtained on each of 3 days during baseline observation, low-sodium and high-sodium interventions, and 2 follow-up studies. Three trajectories of BP responses to dietary sodium intake were identified using latent trajectory analysis. Mean (SD) changes in systolic BP were −13.7 (5.5), −4.9 (3.0), and 2.4 (3.0) mm Hg during the low-sodium intervention and 11.2 (5.3), 4.4 (4.1), and −0.2 (4.1) mm Hg during the high-sodium intervention ( P <0.001 for group differences) in high sodium-sensitive, moderate sodium-sensitive, and sodium-resistant groups, respectively. Compared with individuals with moderate sodium sensitivity, multiple-adjusted odds ratios (95% CIs) for incident hypertension were 1.43 (1.03–1.98) for those with high sodium sensitivity and 1.43 (1.03–1.99) for those with sodium resistance ( P =0.006 for nonlinear trend). Furthermore, a J-shaped association between systolic BP responses to sodium intake and incident hypertension was identified ( P <0.001). Similar results were observed for diastolic BP. Our study indicates that individuals with either high sodium sensitivity or sodium resistance are at an increased risk for developing hypertension.


Hypertension ◽  
2014 ◽  
Vol 64 (2) ◽  
pp. 287-295 ◽  
Author(s):  
Richard A. Preston ◽  
David Afshartous ◽  
Barry J. Materson ◽  
Rolando Rodco ◽  
Alberto B. Alonso

Hypertension ◽  
2001 ◽  
Vol 38 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Yoshio Konishi ◽  
Noriyuki Okada ◽  
Mikio Okamura ◽  
Takashi Morikawa ◽  
Michiaki Okumura ◽  
...  

Hypertension ◽  
1987 ◽  
Vol 10 (4) ◽  
pp. 443-446 ◽  
Author(s):  
M H Weinberger ◽  
J Z Miller ◽  
N S Fineberg ◽  
F C Luft ◽  
C E Grim ◽  
...  

1987 ◽  
Vol 82 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Friedrich C. Luft ◽  
Myron H. Weinberger ◽  
Naomi S. Fineberg ◽  
Judy Z. Miller ◽  
Clarence E. Grim

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