Intra-Renal Factors in Renin Release

2015 ◽  
pp. 5-15 ◽  
Author(s):  
W. S. Peart
Keyword(s):  
Renin Release

Adrenomedullin Stimulates Renin Release and Renin mRNA in Mouse Juxtaglomerular Granular Cells

Hypertension ◽  
1997 ◽  
Vol 29 (5) ◽  
pp. 1148-1155 ◽  
Author(s):  
Boye L. Jensen ◽  
Bernhard K. Krämer ◽  
Armin Kurtz
Keyword(s):  
Renin Release ◽  
Granular Cells ◽  
Renin Mrna

Antagonistic effect of theophylline on the adenosine-induced decreased in renin release

1984 ◽  
Vol 247 (2) ◽  
pp. F246-F251 ◽  
Author(s):  
W. S. Spielman
Keyword(s):  
Angiotensin Ii ◽  
Sodium Excretion ◽  
Renal Cortex ◽  
Fractional Excretion ◽  
Antagonistic Effect ◽  
Renin Release ◽  
Detectable Effect ◽  
Fractional Sodium Excretion ◽  
Fractional Excretion Of Sodium ◽  
Anesthetized Dogs

The action of theophylline on the adenosine-induced decrease in renin release was studied in anesthetized dogs. Adenosine inhibited renin release, decreased GFR and fractional sodium excretion, and decreased the concentration of angiotensin II in the renal lymph. Theophylline (5 mumol/min intrarenally) had no significant effect on GFR or RBF yet produced a significant increase in the release of renin and the fractional excretion of sodium. The intrarenal infusion of adenosine (3 X 10(-7) mol/min) during theophylline infusion produced no effect on GFR or RBF, but fractional sodium excretion and renin release were significantly decreased. Adenosine was infused at a lower dose (3 X 10(-8) mol/min) during theophylline (5 X 10(-6) mol/min) infusion in a second group of dogs. With the exception of fractional sodium excretion, all effects of adenosine were effectively antagonized by theophylline. Theophylline at 5 X 10(-6) mol/min, which stimulates renin release and effectively antagonizes the renal effects of adenosine, had no detectable effect on cAMP measured in renal cortex. Furthermore, no change in cortical cAMP was observed until theophylline was increased 50-fold over the dose effective in antagonizing adenosine. These findings demonstrate that theophylline, at concentrations having no effect on cortical cAMP, antagonizes the effect of adenosine on renin release. The results are also consistent with the view that theophylline stimulates renin release by a mechanism other than its action on cAMP.

The role of osmolarity in renin release from afferent arterioles

1989 ◽  
Vol 7 (9) ◽  
pp. 757???762 ◽  
Author(s):  
Bao M. Twu ◽  
Michael E. Cannon ◽  
Chen H. Hsu
Keyword(s):  
Renin Release ◽  
Afferent Arterioles

scholarly journals Regulation of renin release is impaired after nitric oxide inhibition

1996 ◽  
Vol 49 (3) ◽  
pp. 626-633 ◽  
Author(s):  
Christos Chatziantoniou ◽  
Marie-Dominique Pauti ◽  
Florence Pinet ◽  
Dominique Promeneur ◽  
Jean-Claude Dussaule ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renin Release ◽  
Nitric Oxide Inhibition ◽  
Oxide Inhibition

Enhancement of the Antihypertensive Effect of Hydrochlorothiazide in Dogs after Suppression of Renin Release by Beta-Adrenergic Blockade

1975 ◽  
Vol 48 (2) ◽  
pp. 147-151
Author(s):  
C. S. Sweet ◽  
M. Mandradjieff
Keyword(s):  
Blood Pressure ◽  
Plasma Renin Activity ◽  
Arterial Blood Pressure ◽  
Antihypertensive Effect ◽  
Plasma Renin ◽  
Renin Activity ◽  
Renin Release ◽  
Antihypertensive Activity ◽  
Adrenergic Blockade ◽  
Arterial Blood

1. Renal hypertensive dogs were treated with hydrochlorothiazide (8−2 μmol/kg or 33 μmol/kg daily for 7 days), or timolol (4.6 μmol/kg daily for 4 days), a potent β-adrenergic blocking agent, or combinations of these drugs). Changes in mean arterial blood pressure and plasma renin activity were measured over the treatment period. 2. Neither drug significantly lowered arterial blood pressure when administered alone. Plasma renin activity, which did not change during treatment with timolol, was substantially elevated during treatment with hydrochlorothiazide. 3. When timolol was administered concomitantly with hydrochlorothiazide, plasma renin activity was suppressed and blood pressure was significantly lowered. 4. These observations suggest that compensatory activation of the renin-angiotensin system limits the antihypertensive activity of hydrochlorothiazide in renal hypertensive dogs and suppression of diuretic-induced renin release by timolol unmasks the antihypertensive effect of the diuretic.

Sympathetic Modulation of the Pressure-Dependent Renin Release in Conscious Dogs

1987 ◽  
Vol 9 (sup1) ◽  
pp. 167-180 ◽  
Author(s):  
H. Kirchheim ◽  
H. Ehmke ◽  
S. Fischer ◽  
W. Löwe ◽  
P. Persson
Keyword(s):  
Conscious Dogs ◽  
Renin Release ◽  
Sympathetic Modulation
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