Comments on Multicenter Trials of Antidepressant Drugs

Frequently Used Antidepressant Drugs

PsycEXTRA Dataset ◽

10.1037/e502432012-001 ◽

2013 ◽

Keyword(s):

Antidepressant Drugs

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It's Your Health: Antidepressant Drugs

PsycEXTRA Dataset ◽

10.1037/e611462012-001 ◽

2011 ◽

Keyword(s):

Antidepressant Drugs

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Multicenter Trials for Brain Trauma Questioned

Clinical Psychiatry News ◽

10.1016/s0270-6644(05)70535-x ◽

2005 ◽

Vol 33 (7) ◽

pp. 50

Author(s):

JANE SALODOF MACNEIL

Keyword(s):

Brain Trauma ◽

Multicenter Trials

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Association between body weight and serum concentration of antidepressant drugs

Pharmacopsychiatry ◽

10.1055/s-0035-1558047 ◽

2015 ◽

Vol 48 (06) ◽

Author(s):

B Warrings ◽

J Deckert ◽

S Unterecker

Keyword(s):

Body Weight ◽

Serum Concentration ◽

Antidepressant Drugs

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Percentage of Inadequate Phlebograms and Observer Agreement in Thromboprophylactic Multicenter Trials Using Standardized Methodology and Central Assessment

Thrombosis and Haemostasis ◽

10.1055/s-0038-1650682 ◽

1996 ◽

Vol 76 (06) ◽

pp. 0893-0896 ◽

Cited By ~ 26

Author(s):

P Kälebo ◽

S Ekman ◽

S Lindbratt ◽

B I Eriksson ◽

U Pauli ◽

...

Keyword(s):

Standard Method ◽

Observer Agreement ◽

Observer Variability ◽

Intraobserver Agreement ◽

Multicenter Trials ◽

Kappa Value

SummaryThis study examines inadequacy rates for phlebography in two multicenter trials for the prevention of post-operative DVT and determines inter- and intra-observer variability in evaluating phlebograms. A total of 991 (I) and 385 (II) patients underwent bilateral phlebography in two studies of thromboprophylaxis. Phlebography was performed using a standard method designed to visualize and assess all deep veins. Each vein was scored as normal, DVT or inadequate by both local and central assessment. The study showed low inadequacy rates for phlebograms of 12.2% (121/991) and 6.5% (25/385). Inter-observer agreement (local vs. central assessment) was moderate in both studies (1:74.8%, Kappa-value 0.41; II: 82.6%, Kappa-value 0.51). Good intraobserver agreement (within the central assessment group) was observed (I: 88.8%, Kappa-value 0.75). This study demonstrates low inadequacy rates for phlebograms using a standardized methodology and superior intra-observer agreement compared to inter-observer agreement and supports the importance of central assessment of phlebograms in thromboprophylactic multicenter trials to reduce observer variability.

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