Aims and Implementation of Multicentre Studies

2015 ◽  
pp. 1-8 ◽  
Author(s):  
N. Sartorius ◽  
H. Helmchen
Keyword(s):  
Multicentre Studies

scholarly journals Reducing bias and increasing surgical knowledge: multicentre prospective breast cancer studies

2021 ◽  
Vol 108 (3) ◽  
pp. 231-232
Author(s):  
M Sund
Keyword(s):  
Breast Cancer ◽  
Breast Surgery ◽  
Risk Of Bias ◽  
Multicentre Studies ◽  
Multicentre Trials ◽  
Cancer Studies

Abstract In the March issue of BJS several hot topics within the breast surgery field are highlighted in beautifully planned and executed prospective multicentre trials. BJS encourages the surgical communities in most fields to move towards prospective collaborative and multicentre studies, thereby increasing both power and generalizability as well as reducing the risk of bias.

scholarly journals Turn down of acute aortic syndrome cases during COVID‐19: Results from UK multicentre studies

2020 ◽  
Vol 36 (1) ◽  
pp. 199-202
Author(s):  
Marius Roman ◽  
Amer Harky ◽  
Andrew Brazier ◽  
Kelvin Lim ◽  
George Gradinariu ◽  
...  
Keyword(s):  
Acute Aortic Syndrome ◽  
Multicentre Studies

scholarly journals How to conduct implementation trials and multicentre studies in the emergency department

CJEM ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 448-452
Author(s):  
Ian G. Stiell ◽  
Jeffrey J. Perry ◽  
Jamie Brehaut ◽  
Erica Brown ◽  
Janet A. Curran ◽  
...  
Keyword(s):  
Emergency Department ◽  
Emergency Medicine ◽  
Implementation Research ◽  
Pediatric Emergency ◽  
Research Infrastructure ◽  
Pediatric Emergency Medicine ◽  
Structured Interviews ◽  
Local Study ◽  
Multicentre Studies ◽  
Implementation Studies

AbstractObjectiveThe objective of Panel 2b was to present an overview of and recommendations for the conduct of implementation trials and multicentre studies in emergency medicine.MethodsPanel members engaged methodologists to discuss the design and conduct of implementation and multicentre studies. We also conducted semi-structured interviews with 37 Canadian adult and pediatric emergency medicine researchers to elicit barriers and facilitators to conducting these kinds of studies.ResultsResponses were organized by themes, and, based on these responses, recommendations were developed and refined in an iterative fashion by panel members.ConclusionsWe offer eight recommendations to facilitate multicentre clinical and implementation studies, along with guidance for conducting implementation research in the emergency department. Recommendations for multicentre studies reflect the importance of local study investigators and champions, requirements for research infrastructure and staffing, and the cooperation and communication between the coordinating centre and participating sites.

Overcoming Scanner Variability In Multicentre Studies Using CT Lung Densitometry

2010 ◽  
Author(s):  
Deepak Subramanian ◽  
Greg Gibbons ◽  
Adam Land ◽  
Ken Young ◽  
David Parr
Keyword(s):  
Multicentre Studies ◽  
Lung Densitometry

Ex post facto assessment of diffusion tensor imaging metrics from different MRI protocols: Preparing for multicentre studies in ALS

2015 ◽  
Vol 16 (1-2) ◽  
pp. 92-101 ◽  
Author(s):  
Johannes Rosskopf ◽  
Hans-Peter Müller ◽  
Jens Dreyhaupt ◽  
Martin Gorges ◽  
Albert C. Ludolph ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Multicentre Studies ◽  
Ex Post ◽  
Ex Post Facto

Gradual withdrawal of zopiclone (7.5 mg) and zolpidem (10 mg) in insomniacs treated for at least 3 months

1995 ◽  
Vol 10 (S3) ◽  
pp. 161s-165s ◽  
Author(s):  
P Lemoine ◽  
H Allain ◽  
C Janus ◽  
P Sutet
Keyword(s):  
Adverse Event ◽  
Withdrawal Syndrome ◽  
Control Groups ◽  
Double Blind ◽  
Sleep Complaints ◽  
Multicentre Studies ◽  
Number Of Patients ◽  
Discontinuation Of Treatment

SummaryTwo distinct double-blind randomized multicentre studies were undertaken at the same time using the same design. Patients treated for insomnia with zopiclone 7.5 mg or zolpidem 10 mg for at least three months were allocated to two groups: gradual withdrawal or control. In each study the two groups were compared but there was no comparison between zopiclone and zolpidem. The main criteria was the number of patients in each group with “withdrawal syndrome” defined as: the occurrence of an adverse event, or premature discontinuation of treatment or a total score increase of at least 3 points on the Tyrer questionnaire. In both studies the incidence of “withdrawal syndrome” as defined above was significantly higher in the “withdrawal” groups than in the “control” groups 38% vs 20% for zopiclone p = 0.008 and 38% vs 24% for zolpidem P = 0.049. In most cases, the notified symptoms were sleep complaints.

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