Effects of Cannabinoid Compounds on Aggressive Behavior1

2015 ◽  
pp. 82-102
Author(s):  
E. A. Carlini
Keyword(s):  
Cannabinoid Compounds

An Introduction to Cannabis

2017 ◽  
Author(s):  
Linda A. Parker
Keyword(s):  
Therapeutic Potential ◽  
Scientific Investigation ◽  
Human History ◽  
Preclinical Research ◽  
Cannabinoid Compounds ◽  
Psychoactive Effects ◽  
The Brain

Although cannabis has been used throughout human history, the scientific investigation of its effects only began with the isolation of THC in the 1960’s. Once discovered it was another 20 years before the mechanism by which THC produces its psychoactive effects in the brain, the CB1 receptor, was discovered. Cannabis contains over 80 cannabinoid compounds, but THC is the only intoxicating compound. Recent preclinical research is being directed towards evaluating the therapeutic potential of other cannabinoid compounds found in cannabis, including CBD. The pharmacokinetics of THC, methods of administration, and dosing issues are explored in Chapter 1.

A correlation between geometric features and analgesic activity for a series of cannabinoid compounds

1998 ◽  
Vol 441 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Saulo L. da Silva ◽  
Agnaldo Arroio ◽  
Albérico B.F. da Silva ◽  
Milan Trsic
Keyword(s):  
Analgesic Activity ◽  
Geometric Features ◽  
Cannabinoid Compounds

Estrogenic effects of marijuana smoke condensate and cannabinoid compounds

2006 ◽  
Vol 214 (3) ◽  
pp. 270-278 ◽  
Author(s):  
Soo Yeun Lee ◽  
Seung Min Oh ◽  
Kyu Hyuck Chung
Keyword(s):  
Estrogenic Effects ◽  
Cannabinoid Compounds

scholarly journals Neuroprotective Aspects of Cannabinoid Compounds

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Molecular Mechanisms ◽  
Reliable Data ◽  
Protective Effects ◽  
Neuroprotective Agents ◽  
Beneficial Effects ◽  
Cannabinoid Compounds ◽  
The Central Nervous System ◽  
Effective Use

The accumulation of reliable data on the effects of cannabinoids is essential for understanding their possible beneficial effects on the central nervous system (CNS). Investigating individual substances along with the action of different combinations may show new possibilities for cannabinoids as neuroprotective agents. The data collected so far reveals the complexity of the mechanism of cannabinoids action on CNS, and even more complex and poorly understood are the effects when combined. Moreover, combining cannabinoids with different drugs and chemicals may lead to a decrease in beneficial effects. These characteristics of their action emphasize the complexity of the molecular mechanisms of neuroprotection and the lack of reliable information that may contribute to the safe and effective use of cannabinoids as medicines with valuable neuroprotective properties. The current brief review summarizes present data related to the protective effects of some cannabinoids on CNS and possible mechanisms involved in cannabinoid-mediated neuroprotection.

scholarly journals Genotype screening of Cannabis sativa L. based on the specifics of minor cannabinoids manifestation

2021 ◽  
Vol 17 (3) ◽  
pp. 218-225
Author(s):  
S. V. Mishchenko ◽  
H. I. Kyrychenko ◽  
I. М. Laiko
Keyword(s):  
Cannabis Sativa ◽  
Negative Relationship ◽  
Correlation Coefficients ◽  
Linear Relationships ◽  
Synthetic Populations ◽  
Strong Positive Relationship ◽  
Cannabinoid Compounds ◽  
Multiple Correlation Coefficients ◽  
Relationship Of ◽  
Genotype Screening

Analysis of hemp collection samples based on the content of minor (rare) non-psychotropic cannabinoids, such as cannabichromene (CBC), cannabidivarin (CBDV), and cannabinol (CBN); determination of correlation relationships between them and common compounds; selection of valuable breeding genotypes. Methods. Field, biochemical (gas chromatography of cannabinoid compounds), and statistical (pair, partial, and multiple linear correlations). Results. Quantitative analysis of 210 samp­les of various ecological-geographical and genetic origin (local and wild forms, self-filing lines, hybrids, varieties, synthetic populations, polyploids) with a tetrahydrocannabinol (THC) content of less than 0.08% in dried plants showed the level of manifestation of the trait from its absence within the sensitivity of the gas chromatograph up to 0.6838% CBC, 0.1719% CBC and 0.3274% CBN. In the studied hemp samples, a medium negative relationship was found between the signs of the CBC and cannabidiol (CBD) contents (r = –0.53), a weak negative relationship between CBC and CBDV contents (r = –0.35), medium positive relationships between the signs of CBC and THC contents (r = 0.57) and CBC and CBN contents (r = 0.59). A medium positive correlation (r = 0.57) was found between the signs of CBDV and CBD contents, while CBN had a strong positive relationship with THC (r = 0.82). There is almost no correlation between cannabigerol (CBG) and the minor cannabinoids under study. The biosynthesis of minor cannabinoid compounds is quite complex. Signs manifestation is affected by many genetic and external factors. Partial correlation coefficients (given that one of the three signs is eliminated) and multiple correlation coefficients (given that the relationship of one sign is determined and two other signs are combined) give grounds to state that the gene for CBCA-synthase affects the production of CBD and, in particular THC. Conclusions. The closeness of the linear relationships between minor cannabinoids and common components allows selecting valuable hemp samples with a high content of one or several compounds under the absence or low content of psychotropic THC.

Analgesic efficacy of cannabinoids for acute pain management after surgery: a systematic review and meta-analysis

2020 ◽  
Vol 45 (7) ◽  
pp. 509-519 ◽  
Author(s):  
Faraj W Abdallah ◽  
Nasir Hussain ◽  
Tristan Weaver ◽  
Richard Brull
Keyword(s):  
Postoperative Pain ◽  
Meta Analysis ◽  
Oral Morphine ◽  
Analgesic Efficacy ◽  
Acute Postoperative Pain ◽  
Acute Pain Management ◽  
Cannabinoid Compounds ◽  
Oral Morphine Equivalent ◽  
Morphine Equivalent

BackgroundEvidence regarding the role of cannabinoids in managing acute postoperative pain is conflicting. The purpose of this systematic review and meta-analysis was to determine the analgesic efficacy of perioperative cannabinoid compounds for acute pain management after surgery.MethodsOriginal research articles evaluating the addition of cannabinoids to standard opioid-based systemic analgesia (Control) in the postoperative period were sought. Our primary outcomes were cumulative oral morphine equivalent consumption and rest pain severity at 24 hours postoperatively. We also assessed analgesic consumption in the postanesthesia care unit (PACU), pain scores in PACU, 6 and 12 hours postoperatively, and opioid-related and cannabinoid-related side effects, patient satisfaction, and quality of recovery as secondary outcomes.ResultsEight randomized controlled trials (924 patients) and four observational studies (4259 patients) were analyzed and included. There were insufficient data to pool for quantification of differences in cumulative oral morphine equivalent consumption and rest pain severity at 24 hours postoperatively with the addition of cannabinoids in comparison to Control. Qualitative synthesis revealed no differences in cumulative oral opioid consumption or pain at rest 24 hours postoperatively with the addition of cannabinoids in comparison to Control. Patients receiving cannabinoids appeared to have an increased weighted mean difference 95% CI of pain at 12 hours by 0.83 cm (0.04 to 1.63) (p=0.04). Patients receiving cannabinoids also appeared to have 3.24 times increased odds of developing hypotension postoperatively (95% CI 1.12 to 9.36) (p=0.03). Qualitative and quantitative synthesis revealed no differences in any other secondary outcomes.ConclusionsOur quantitative and qualitative review of the literature suggests that the analgesic role of perioperative cannabinoid compounds is limited, with no clinically important benefits detected when cannabinoids are added to traditional systemic analgesics compared with traditional systemic analgesics alone. Notably, there appears to be a signal towards increased postoperative pain and hypotension associated with the addition of perioperative cannabinoids to traditional systemic analgesics. These results do not support the routine use of cannabinoids to manage acute postoperative pain at the present time.

Monoclonal Antibody Based Enzyme Immunoassay for Marihuana (Cannabinoid) Compounds+

1996 ◽  
Vol 17 (4) ◽  
pp. 321-342 ◽  
Author(s):  
Hiroyuki Tanaka ◽  
Yuri Goto ◽  
Yukihiro Shoyama
Keyword(s):  
Monoclonal Antibody ◽  
Enzyme Immunoassay ◽  
Cannabinoid Compounds
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