Metabolic Clearance and Production Rate of Growth Hormone in Juvenile Diabetics

2015 ◽  
pp. 105-108
Author(s):  
Mark A. Sperling ◽  
Fleming Wollesen
Keyword(s):  
Growth Hormone ◽  
Production Rate ◽  
Metabolic Clearance ◽  
Rate Of Growth ◽  
Juvenile Diabetics

Metabolic Clearance Rate of Growth Hormone in Mice during Various Physiological States*

Endocrinology ◽  
1979 ◽  
Vol 105 (3) ◽  
pp. 685-689 ◽  
Author(s):  
Y. N. SINHA ◽  
S. R. BAXTER ◽  
W. P. VANDERLAAN
Keyword(s):  
Growth Hormone ◽  
Clearance Rate ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Rate Of Growth

Metabolic Clearance Rate of Growth Hormone in Juvenile Diabetes Mellitus

Diabetes ◽  
1972 ◽  
Vol 21 (3) ◽  
pp. 175-177 ◽  
Author(s):  
R. L. Lipman ◽  
A. L. Taylor ◽  
P. Conly ◽  
D. H. Mintz
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Clearance Rate ◽  
Juvenile Diabetes ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Juvenile Diabetes Mellitus ◽  
Rate Of Growth

scholarly journals Secretory profiles and production rate of growth hormone in ruminant lambs

1987 ◽  
Vol 27 (2B) ◽  
pp. 525-532 ◽  
Author(s):  
M. P. LAURENTIE ◽  
M. DUCLOS ◽  
P. L. TOUTAIN ◽  
J. CHARRIER ◽  
Monique BLANCHARD ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Production Rate ◽  
Rate Of Growth

Metabolic Clearance Rate of Growth Hormone during Experimental Growth Arrest and Subsequent Recovery in Rats*

Endocrinology ◽  
1980 ◽  
Vol 107 (3) ◽  
pp. 744-748 ◽  
Author(s):  
H. D. MOSIER ◽  
R. A. JANSONS ◽  
C. S. BIGGS ◽  
S. M. TANNER ◽  
L. C. DEARDEN
Keyword(s):  
Growth Hormone ◽  
Clearance Rate ◽  
Growth Arrest ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Subsequent Recovery ◽  
Rate Of Growth

IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT

1974 ◽  
Vol 75 (1) ◽  
pp. 50-63 ◽  
Author(s):  
Kristian F. Hanssen
Keyword(s):  
Growth Hormone ◽  
Insulin Treatment ◽  
Juvenile Diabetes ◽  
Control Group ◽  
List Type ◽  
Newly Diagnosed ◽  
Renal Tubular Reabsorption ◽  
Juvenile Diabetics ◽  
The Mean ◽  
Renal Tubular

ABSTRACT Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment. The plasma IRHGH was significantly higher (0.05 > P > 0.01) before than during initial insulin treatment. During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 > P > 0.001) than in a control group. The urinary IRHGH was significantly higher (0.01 > P > 0.001) before than during insulin treatment. The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone. No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.

Production rate, metabolic clearance rate and blood concentration of progesterone in conscious and anaesthetized pregnant rats

1984 ◽  
Vol 102 (3) ◽  
pp. 357-363 ◽  
Author(s):  
B. J. Waddell ◽  
N. W. Bruce
Keyword(s):  
Production Rate ◽  
Clearance Rate ◽  
Blood Concentration ◽  
Constant Infusion ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Short Term ◽  
Pregnant Rats ◽  
Pregnant Rat ◽  
Anaesthetized Rats

ABSTRACT Both production rate and metabolic clearance rate (MCR) of progesterone may vary rapidly and so effect short-term changes in blood concentration of the hormone. Here, a constant infusion and sampling technique was used to estimate these three characteristics of progesterone metabolism in seven conscious and ten anaesthetized rats on day 16 of pregnancy. After steady state was achieved, four samples were collected during a 1-h period from each rat. Mean values for production rate and MCR of progesterone in conscious rats were 14·0 ±1·4 μmol/day and 63·2 ± 6·2 litres/day respectively. Both values were substantially reduced in anaesthetized rats (8.6 ±0·8 μmol/ day and 39·4± 3·4 litres/day respectively) and so blood concentration was unchanged. The production rate was positively related to the total mass of luteal tissue (common correlation coefficient, r = 0·61, P <0·05). There were no consistent changes in the three characteristics with time but variation within rats was high. The estimated coefficients of variation for production rate, MCR and blood concentration within rats were 26, 18 and 17% in conscious and 27, 20 and 23% in anaesthetized rats respectively. Short-term changes in production rate and MCR generally were in the same direction (P <0·05). This reduced variation in blood concentration which would otherwise have occurred if production rate and MCR were unrelated. The pregnant rat is clearly capable of rapid shifts in production rate, MCR and blood concentration of progesterone and the positive relationship between production rate and MCR has a homeostatic effect on blood concentration. J. Endocr. (1984) 102, 357–363

ADRENAL FUNCTION IN BREAST CANCER: PRODUCTION AND METABOLIC CLEARANCE RATE OF CORTISOL IN PATIENTS WITH EARLY OR ADVANCED BREAST CANCER AND IN NORMAL WOMEN *

1968 ◽  
Vol 42 (3) ◽  
pp. 425-432 ◽  
Author(s):  
V. JENSEN ◽  
N. DESHPANDE ◽  
R. D. BULBROOK ◽  
T. W. DOOUSS
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Cancer Patients ◽  
Production Rate ◽  
Clearance Rate ◽  
Advanced Breast ◽  
Metabolic Clearance ◽  
Breast Cancer Patients ◽  
Metabolic Clearance Rate ◽  
Significant Difference

SUMMARY The production rate of cortisol in patients with early or advanced breast cancer was compared with that of controls of comparable age. The miscible pool of this hormone was raised in advanced breast-cancer patients due to a higher production rate. The plasma clearance of cortisol remained unaffected, resulting in a higher titre of cortisol (both total and unbound) in advanced breast-cancer patients. There was no significant difference in the production rate between the early breast-cancer cases and controls. The binding of cortisol to transcortin was studied in all cases. The amount of unbound cortisol was raised in advanced breast-cancer cases. There was a significant correlation between both total and unbound cortisol and the production rate of this hormone. The latter correlation suggests that there is no abnormality in the hepatic extraction of cortisol in these patients. The metabolic clearance rate was found to be of the order of the blood flow through the liver when unbound cortisol was used for its estimation, showing that it is the unbound cortisol which is removed by the liver.

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