Implications of a Somatic Mutational Approach to Ageing for Gerontological Research

2015 ◽  
pp. 30-36 ◽  
Author(s):  
F. M. Burnet
Keyword(s):  
Gerontological Research

scholarly journals Transforming Gerontological Research by Meaningfully Engaging Persons Living With Dementia

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 728-728
Author(s):  
Michael Lepore ◽  
Richard Fortinsky
Keyword(s):  
Research Participation ◽  
The United States ◽  
International Studies ◽  
Care Services ◽  
Care Partners ◽  
Gerontological Research ◽  
Scientific Meetings ◽  
Conducting Research ◽  
Services And Supports ◽  
Study Designs

Abstract Whereas persons living with dementia have commonly been subjects of gerontological research, participation of persons with dementia in designing and conducting studies and in scientific research meetings has been rare in the United States. In recent years, person-centered research models have arisen which give persons with dementia and their caregivers core roles in the research enterprise. As “co-researchers” with academic/professional researchers, persons with dementia and their caregivers are engaged in all aspects of the research enterprise, jointly developing research questions and study designs, collecting and analyzing data, planning research meetings, and disseminating results. International studies have shown that conducting research in collaboration with the population that is being studied has potential to enhance the quality and appropriateness of research and has been identified as an essential component of studies examining the effectiveness of different approaches to care. This session spotlights innovative advances in gerontological research that meaningfully engages persons with dementia. First, the engagement of persons with dementia in scientific meetings is addressed drawing on the examples of the 2017 and 2020 National Research Summits on Care Services and Supports for Persons with Dementia and their Caregivers (i.e., Summits). Next, a study using a patient engagement framework for caregivers and individuals with mild cognitive impairment living at home is discussed. Finally, the Empowering Partnerships program, which prepares researchers, persons with dementia, and care partners to collaborate in conducting research is reviewed. Outcomes and challenges of these innovations are examined, and the need for academic/professional researcher roles to evolve is discussed.

Clinical Translation of Anti-aging Associated Genetics: Current Progress and Challenges

2021 ◽  
Vol 14 ◽  
Author(s):  
Yi Wang
Keyword(s):  
Genetic Manipulation ◽  
Large Body ◽  
Cost Effective ◽  
Clinical Applications ◽  
Biological Aging ◽  
Aging Research ◽  
Gene Therapies ◽  
Molecular Approaches ◽  
Gerontological Research ◽  
Tremendous Challenge

Background: Currently, the focus of anti-aging research has been changed from geriatrics to biogerontology. This has taken anti-aging strategies from cost-effective but palliative therapeutics to active, molecular approaches. Outline: Over the years, a large body of basic gerontological research has indicated that the process of biological aging is closely associated with genetic factors. This leads to the development of various gene therapies such as RNA interference technology and results in a subsequent need of translating laboratory achievements into clinical applications. The translation has been a tremendous challenge at this stage with respect to practicality, safety and effectiveness of the genetic manipulation techniques. Objective: This review summarizes the current development of anti-aging strategies and the progress in the translation of laboratory achievements into clinical applications, highlights challenges encountered, and provides a prospective outlook for future anti-aging research.

scholarly journals Neuronal ceroid-lipofuscinosis, a type of amaurotic family idiocy: clinical and pathological study of four cases

1974 ◽  
Vol 32 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Luciano de Souza Queiroz ◽  
Joaquim N. da Cruz Neto ◽  
J. Lopes de Faria
Keyword(s):  
Late Onset ◽  
Neuronal Ceroid Lipofuscinosis ◽  
Cerebral Atrophy ◽  
Cell Loss ◽  
Storage Material ◽  
Brazilian Literature ◽  
Ceroid Lipofuscinosis ◽  
Tay Sachs Disease ◽  
Gerontological Research

Neuronal ceroid-lipofuscinosis (NCL) is a recent term, proposed for acurate designation of the late-onset types of Amaurotic Family Idiocy (AFI). Histopathology shows ubiquitous intraneuronal accumulation of lipopigments, being the most important factor for characterization of the entity at present time. Biochemical changes and pathogenesis are obscure. NCL is in contrast to the infantile type of AFI (Tay-Sachs disease), in which intraneuronal accumulation of gangliosides (sphingolipids) is due to the well known deficiency of a lysosomal enzyme. The authors report on four cases of NCL, two brothers of the late infantile (Jansky-Bielschowsky) type and a brother and a sister of the juvenile (Spielmeyer-Sjögren) type. One autopsy and three cortical biopsies revealed moderate to severe distention of the neurons by lipopigment, with nerve cell loss, gliosis and cerebral atrophy. Lipopigment was also increased in liver, heart and spleen. The patients were the first in Brazilian literature in whom the storage material was identified as lipopigment by histochemical methods. A brief summary of the clinical features of NCL is presented, and relevant problems are discussed, concerning interpretation of the nature of the storage material, and significance of the disease for gerontological research.

Sex in an ideology of love

2017 ◽  
Author(s):  
Torbjörn Bildtgård ◽  
Peter Öberg
Keyword(s):  
Older People ◽  
Life Course ◽  
Case Studies ◽  
Intimate Relationships ◽  
Later Life ◽  
Sexual Intimacy ◽  
Sexual Norms ◽  
Gerontological Research ◽  
The Life Course ◽  
Loving Relationship

Until recently the sex life of older people was more or less invisible in family and gerontological research. This chapter contributes to breaking this silence by focusing on the role and meaning of sex in intimate relationships in later life. Based on biographical case studies, the chapter investigates how sexual norms have changed over the life course of contemporary cohorts of older people and how they have experienced this change. The chapter considers sexual intimacy as part of new intimate relationships established late in life and questions the persistent assumption that older people who date are primarily looking for companionate relationships. It is shown that older people’s ideas about sex are deeply embedded in an ideology of love, where sex tends to be viewed as a natural part of a loving relationship, while sex outside of a loving relationship – also in a loveless marriage – is frowned on.

scholarly journals Theorizing Cultural and Social Intersections of Age and Gender: The Approach of Anocriticism

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 826-826
Author(s):  
Roberta Maierhofer
Keyword(s):  
Cultural Construction ◽  
Cultural Representations ◽  
Four Dimensions ◽  
Gerontological Research ◽  
Gender And Age ◽  
Methodological Approaches ◽  
And Gender ◽  
Narrative Performance ◽  
The Individual ◽  
Individual Dimension

Abstract This contribution discusses empirical applications of the approach of ‘anocriticism’ in interdisciplinary gerontological research. Despite the connection in terms of epistemology and ontology, the intersection of gender and age has been mostly ignored, privileging works focusing either on age or gender (Calasanti & Slevin 2001:27; Denninger & Schütze 2017:7). Age/ing Studies, however, would not have been established as a field without the theoretical and methodological approaches of feminist theory (Maierhofer (2019:2). Anocriticism was originally developed in order to investigate cultural representations of age/ing (Maierhofer 2003, 2004b, 2004a, 2007, 2012), but has recently been taken up in social sciences (Ratzenböck 2016a, 2016b, 2017a, 2017b; Gales and Loos 2020, forthcoming) in order to draw attention to four dimensions: (a) age and aging’s collective cultural construction and relation to gender, (b) the individual dimension of aging, (c) people’s interpretative power and narrative performance, and (d) age/ing’s potential for resistance and change.

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