scholarly journals Molecular aspects of DNA repair

1987 ◽  
Vol 184 (2) ◽  
pp. 67-86 ◽  
Author(s):  
E.C. Friedberg ◽  
C. Backendorf ◽  
J. Burke ◽  
A. Collins ◽  
L. Grossman ◽  
...  
Keyword(s):  
Dna Repair ◽  
Molecular Aspects

scholarly journals Molecular aspects during seed germination of Erythrina velutina Willd. under different temperatures (Part 2): isoenzyme activity and DNA integrity

2020 ◽  
Vol 42 ◽  
Author(s):  
Francival Cardoso Felix ◽  
Josenilda Aprígio Dantas de Medeiros ◽  
Cibele dos Santos Ferrari ◽  
Mauro Vasconcelos Pacheco ◽  
Salvador Barros Torres
Keyword(s):  
Dna Repair ◽  
Seed Germination ◽  
Dna Integrity ◽  
Genetic Apparatus ◽  
Native Tree ◽  
Social Potential ◽  
Different Temperatures ◽  
Molecular Aspects

ABSTRACT: Erythrina velutina Willd. (Fabaceae) is a Brazilian native tree with economic, ecological and social potential. The aim of this study was to evaluate isoenzyme activity and changes in DNA integrity during germination of E. velutina at different temperatures. The seeds were placed to germinate at 5, 15, 25, 35 and 45 °C, evaluating isoenzyme activity and degradation of the DNA during germination. Isoenzyme expression occurs differently for seed germination under different temperatures, with varied expression between seedlings and cotyledons. The esterase enzyme was more sensitive to express the response of the E. velutina germination seeds at different temperatures. DNA repair is more efficient during the germination of E. velutina seeds when submitted to a temperature of up to 25 °C, with damage to the genetic apparatus with an increase higher than this temperature.

Current Translational Insights into MGMT Methylation Regulating Temozolomide Sensitivity and Resistance in Glioblastoma Multiforme

2020 ◽  
Vol 17 (2) ◽  
pp. 76-93 ◽  
Author(s):  
Ishmeet Gulati ◽  
Harsh Patel ◽  
Bala Prabhakar ◽  
Sujit Nair
Keyword(s):  
Dna Repair ◽  
Glioblastoma Multiforme ◽  
Dna Methyltransferase ◽  
Methylguanine Dna Methyltransferase ◽  
Drug Regulator ◽  
Ethnic Variability ◽  
Molecular Aspects ◽  
Functional Relevance

Background: Temozolomide is used as frontline chemotherapy in the management of glioblastoma multiforme (GBM); however, its clinical utility is limited by the occurrence of significant resistance, majorly caused due to direct DNA repair. O6- methylguanine-DNA-methyltransferase (MGMT), a DNA repair protein, mediates this direct repair pathway and reverses the activity of temozolomide. Methods: We characterize and underscore the functional relevance and molecular aspects of MGMT in the development of sensitivity/resistance to temozolomide treatment. We review early translational, as well as clinical, evidence for the role of MGMT in mediating temozolomide resistance in vitro in cell lines, in vivo in small animals as well as in GBM patients. Results: Various approaches have been delineated to mitigate MGMT-induced temozolomide resistance. The most promising means in discovery biology appears to be the co-administration of MGMT inhibitors such as O6 benzyl guanine or lomeguatrib. Surprisingly, the validation of these pharmacologic inhibitors to assess the reversal of chemoresistance by appropriately designed safety and efficacy trials in combination with temozolomide is yet to be demonstrated. Conclusions: Taken together, given the regulation of temozolomide resistance by MGMT, intermediate and late discovery groups may focus their efforts on pharmacologic inhibition of MGMT, singly or in combination with radiotherapy or immunotherapy, to combat temozolomide resistance in GBM patients. In addition, one may speculate that the combined clinical use of temozolomide with a drug regulator-approved MGMT inhibitor as well as an immune checkpoint inhibitor such as nivolumab may prove beneficial. Future studies may also investigate any inter-ethnic variability in population pharmacogenetics of MGMT and pharmacometric approaches to optimize cancer precision medicine.

259: Dna-Repair Genetic Polymorphisms and Prostate Cancer Risk

2005 ◽  
Vol 173 (4S) ◽  
pp. 71-71
Author(s):  
Peter E. Clark ◽  
M. Craig Hall ◽  
Kristin L. Lockett ◽  
Jianfeng Xu ◽  
Sigun L. Zheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Prostate Cancer Risk

983: Bladder Cancer Predisposition: A Pathway-Based Approach to DNA Repair and Cell Cycle Control Genes

2006 ◽  
Vol 175 (4S) ◽  
pp. 317-317
Author(s):  
Xifeng Wu ◽  
Jian Gu ◽  
H. Barton Grossman ◽  
Christopher I. Amos ◽  
Carol Etzel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bladder Cancer ◽  
Dna Repair ◽  
Cell Cycle Control ◽  
Cancer Predisposition

Drugs Impair Keratinocyte DNA Repair in Culture

2005 ◽  
Vol 36 (7) ◽  
pp. 42
Author(s):  
PATRICE WENDLING
Keyword(s):  
Dna Repair

DNA Repair and Transcription in Human Premature Aging Disorders

1998 ◽  
Vol 3 (1) ◽  
pp. 11-13 ◽  
Author(s):  
Vilhelm A Bohr ◽  
Grigoiy Dianov ◽  
Adayabalam Balajee ◽  
Alfred May ◽  
David K Orren
Keyword(s):  
Dna Repair ◽  
Premature Aging
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