Alpha-Fetoprotein in the Diagnosis, Therapy and Monitoring of Infantile and Adult Germ Cell Tumors (Teratocarcinomas) of Gonadal and Extragonadal Origin1

1981 ◽  
pp. 39-49
Author(s):  
Bent Nørgaard-Pedersen
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Diagnosis Therapy

Affinity chromatography used in distinguishing alpha-fetoprotein in serum from patients with tumors of hepatic parenchyma and of germ cells.

1984 ◽  
Vol 30 (7) ◽  
pp. 1257-1258 ◽  
Author(s):  
P K Buamah ◽  
C Cornell ◽  
A W Skillen
Keyword(s):  
Germ Cell ◽  
Affinity Chromatography ◽  
Germ Cells ◽  
Concanavalin A ◽  
Primary Liver Cancer ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Hepatic Parenchyma ◽  
Liver Cancers ◽  
Serum Alpha Fetoprotein

Abstract We used affinity chromatography on concanavalin A Sepharose to study the serum alpha-fetoprotein of 10 patients with histologically proven germ-cell tumors and 12 patients with primary liver cancer. Less than 50% of the fetoprotein from germ-cell tumors bound to concanavalin A, as compared with more than 80% of the alpha-fetoprotein from primary liver cancers.

Diagnostic Value of Lectin Reactive Alpha-fetoprotein for Neoinfantile Hepatic Tumors and Malignant Germ Cell Tumors

2008 ◽  
Vol 30 (6) ◽  
pp. 447-450 ◽  
Author(s):  
Yoshiaki Kinoshita ◽  
Tatsuro Tajiri ◽  
Ryota Souzaki ◽  
Kyousuke Tatsuta ◽  
Mayumi Higashi ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Diagnostic Value ◽  
Alpha Fetoprotein ◽  
Hepatic Tumors ◽  
Malignant Germ Cell Tumors

Reversible increase in serum alpha-fetoprotein content associated with hepatic dysfunction during chemotherapy for seminoma.

1986 ◽  
Vol 4 (1) ◽  
pp. 41-45 ◽  
Author(s):  
J L Grem ◽  
D L Trump
Keyword(s):  
Hepatitis B ◽  
Germ Cell ◽  
Hepatic Dysfunction ◽  
Tumor Regression ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein ◽  
Response To Treatment ◽  
Beta Hcg ◽  
B Virus ◽  
Serum Alpha Fetoprotein

Serial monitoring of the serum content of the beta subunit of human chorionic gonadotropin (beta hCG) and alpha-fetoprotein (alpha FP) is useful in the initial staging of germ cell tumors and assessing the response to treatment. An increase in either marker during or following treatment almost always heralds disease progression and indicates the need for additional therapy. We report two patients in whom substantial increases in the serum content of AFP occurred during chemotherapy for advanced seminoma. Hepatic dysfunction was present in both patients; in one patient, a chronic carrier of hepatitis B virus, the liver dysfunction was associated with reactivation of hepatitis B manifested by anicteric hepatitis and hepatitis B e antigen positivity. Marked tumor regression had occurred in both patients, and chemotherapy was discontinued in spite of the elevated alpha FP level. The alpha FP content in the serum gradually returned to normal, and hepatic dysfunction resolved. Both patients remain free of disease 15 and 17 months following the last chemotherapy treatment. These cases illustrate that hepatic dysfunction and alpha FP production may occur during chemotherapy and that increases in serum alpha FP content must be interpreted with caution since the elevated alpha FP level does not always indicate progression of germ cell tumors.

PRODUCTION OF ALPHA-FETOPROTEIN BY HUMAN GERM CELL TUMORS IN VIVO AND IN VITRO

1987 ◽  
Vol 37 (8) ◽  
pp. 1263-1277 ◽  
Author(s):  
Teiichi Motoyama ◽  
Hidenobu Watanabe ◽  
Takahiko Yamamoto ◽  
Morimasa Sekiguchi
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein

scholarly journals Germ cell tumors express a specific alpha-fetoprotein variant detectable by isoelectric focusing

Cancer ◽  
1995 ◽  
Vol 75 (7) ◽  
pp. 1663-1668 ◽  
Author(s):  
Philip J. Johnson ◽  
Stephen Ho ◽  
Paul Cheng ◽  
Anthony Chan ◽  
Thomas Leung ◽  
...  
Keyword(s):  
Germ Cell ◽  
Isoelectric Focusing ◽  
Germ Cell Tumors ◽  
Alpha Fetoprotein
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