The Clinical Course of Breast Cancer: A Psychological Perspective1

Author(s):  
Jimmie Holland
Author(s):  
Leisha C. Elmore ◽  
Henry M. Kuerer ◽  
Carlos H. Barcenas ◽  
Benjamin D. Smith ◽  
Makesha V. Miggins ◽  
...  

2000 ◽  
Vol 59 (3) ◽  
pp. 271-278 ◽  
Author(s):  
E.-F. Solomayer ◽  
I.J. Diel ◽  
G.C. Meyberg ◽  
Ch. Gollan ◽  
G. Bastert

2009 ◽  
Vol 70 (11) ◽  
pp. 3263-3266 ◽  
Author(s):  
Takeshi YAMAGIWA ◽  
Takayuki TAJIMA ◽  
Masato NAKAMURA ◽  
Masaya MUKAI ◽  
Sadaki INOKUCHI ◽  
...  

2002 ◽  
Vol 48 (8) ◽  
pp. 1360-1362 ◽  
Author(s):  
Thomas Schöndorf ◽  
Markus Hoopmann ◽  
Mathias Warm ◽  
Rainer Neumann ◽  
Anke Thomas ◽  
...  

1987 ◽  
Vol 55 (1) ◽  
pp. 61-66 ◽  
Author(s):  
RE Coleman ◽  
RD Rubens

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Milica Nedeljković ◽  
Nikola Tanić ◽  
Tatjana Dramićanin ◽  
Zorka Milovanović ◽  
Snežana Šušnjar ◽  
...  

Summary Background: Triple negative breast cancer (TNBC) is characterized by aggressive clinical course and is unresponsive to anti-HER2 and endocrine therapy. TNBC is difficult to treat and is often lethal. Given the need to find new targets for therapy we explored clinicopathological significance of copy number gain of FGFR1 and c-MYC. Our aim was to determine the impact of FGFR1 and c-MYC copy number gain on clinical course and outcome of TNBC. Methods: FGFR1 and c-MYC gene copy number alterations were evaluated in 78 archive TNBC samples using TaqMan based quantitative real time PCR assays. Results: 50% of samples had increased c-MYC copy number. c-MYC copy number gain was associated with TNBC in contrast to ER positive cancers. Our results showed significant correlation between c-MYC copy number gain and high grade of TNBCs. This suggests that c-MYC copy number could be an useful prognostic marker for TNBC patients. c-MYC copy number gain was associated with high pTNM stage as well as lobular and medullary tumor subtypes. 43% of samples had increased FGFR1 copy number. No correlations between FGFR1 copy number gain and clinicopathological variables were observed. Conclusions: We identified c-MYC copy number gain as a prognostic marker for TNBC. Our results indicate that c- MYC may contribute to TNBC progression. We observed no significant association between c-MYC and/or FGFR1 copy number status and patient survival.


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