Recent Advances in Pain Management

Author(s):  
Huda Akil
1995 ◽  
Vol 65 (9) ◽  
pp. 674-685 ◽  
Author(s):  
Philip J. Siddall ◽  
Michael J. Cousins

2019 ◽  
Vol 16 (8) ◽  
pp. 815-822 ◽  
Author(s):  
Sameer Jain ◽  
Mark Malinowski ◽  
Pooja Chopra ◽  
Vishal Varshney ◽  
Timothy R. Deer

2015 ◽  
Vol 4 (2) ◽  
pp. 149-168 ◽  
Author(s):  
Maurizio de Martino ◽  
Alberto Chiarugi

2018 ◽  
Vol 120 (2) ◽  
pp. 387-390 ◽  
Author(s):  
J. Archibald ◽  
F. M. Warner ◽  
O. Ortiz ◽  
M. Todd ◽  
C. R. Jutzeler

The pursuit of a physiological indicator of noxious stimulation is desirable as it has the potential to provide mechanistic information regarding acute pain and may ultimately improve pain management strategies. Currently, there are no specific neurophysiological markers of pain to evaluate treatments. Recent attempts to identify neural correlates of pain have focused on different neuroimaging modalities. The purpose of this review is to discuss common neuroimaging techniques and findings thus far.


2002 ◽  
Vol 10 (s1) ◽  
pp. s14-s20 ◽  
Author(s):  
Lise K. Lucas ◽  
Arthur G. Lipman

2001 ◽  
Vol 12 (6) ◽  
pp. 296-301 ◽  
Author(s):  
G.T. Linklater ◽  
M.E.F. Leng

Author(s):  
Priyadarsini Baskaran ◽  
Venkatraman Karthikeayan ◽  
Anusha Natarajan

Pain is one of the most common complaints for which patients approach physicians. In spite of this there is a huge unmet need for developing medications for pain that are safe and efficacious. Owing to the heterogeneity of clinical pain and complex pathophysiology, target identification for drug development is difficult. Preclinical models have also proven unreliable for the development of novel analgesics. Recent advances in understanding the physiology of nociception has enabled the development of novel analgesics including abuse deterrent opioids, drugs targeting several receptors, ion channels and enzymes. This review will attempt to cover the physiology of nociception focusing on the novel targets, the challenges in development of novel analgesics and give an overview of the recently developed drugs and those in the pipeline for the management of pain.


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