Studies on the Rate-Limiting Role of d-Aminolevulinic Acid Synthetase in Heme Biosynthesis in Fetal Rat Liver

2015 ◽  
pp. 86-97
Author(s):  
James S. Woods
Keyword(s):  
Rat Liver ◽  
Aminolevulinic Acid ◽  
Heme Biosynthesis ◽  
Fetal Rat ◽  
Fetal Rat Liver ◽  
Rate Limiting

Metallothionein synthesis and localization in relation to metal storage in rat liver during gestation

1985 ◽  
Vol 63 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Douglas M. Templeton ◽  
Diponkar Banerjee ◽  
M. George Cherian
Keyword(s):  
Rat Liver ◽  
Metal Binding ◽  
Protein Composition ◽  
Progressive Increase ◽  
Immunohistochemical Localization ◽  
Late Gestation ◽  
Adult Rat ◽  
Fetal Rat ◽  
Fetal Rat Liver

The metallothionein (MT) content of fetal rat liver was measured daily during the final week of gestation, by both cadmium saturation and polarographic methods. MT levels rise sharply at day 18 of gestation and continue to increase into the neonatal period. In late gestation, MT serves to bind Cu and Zn from the preexisting hepatic pools of these metals, as well as to accumulate additional amounts of both metals The fetal MT is similar to the adult rat protein both in terms of its protein composition and metal-binding properties. Perinatally the Zn/MT ratio remains constant for several days suggesting a carefully regulated process. At birth, most of the hepatic Zn and a significant amount of hepatic Cu are bound to MT. Immunohistochemical localization of MT shows a progressive increase in cytoplasmic MT with the appearance of nuclear MT by day 20 of gestation in fetal rat liver. The results are discussed in terms of a model for regulation of MT synthesis and for the metal storage role of MT in perinatal development.

Effects of Steroids on Fetal Rat Liver

1969 ◽  
Vol 27 ◽  
pp. 350-351
Author(s):  
F. G. Zaki
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Fetal Liver ◽  
Dosage Level ◽  
Maternal Plasma ◽  
Methyl Prednisolone ◽  
Fetal Rat ◽  
Toxic Agents ◽  
Fetal Rat Liver ◽  
Neonatal Liver

Fetal and neonatal liver injury induced by agents circulating in maternal plasma, even though well recognized, its morphological manifestations are not yet established. As part of our studies of fetal and neonatal liver injury induced by maternal nutritional disorders, metabolic impairment and toxic agents, the effects of two anti-inflammatory steroids have been recently inves tigated.Triamcinolone and methyl prednisolone were injected each in a group of rats during pregnancy at a-dosage level of 2 mgm three times a week. Fetal liver was studied at 18 days of gestation. Litter size and weight markedly decreased than those of control rats. Stillbirths and resorption were of higher incidence in the triamcinolone group than in those given the prednisolone.

Changes in the properties of fetal rat liver during organ culture

In Vitro ◽  
1979 ◽  
Vol 15 (8) ◽  
pp. 579-586
Author(s):  
Carl Monder ◽  
Alena Hatle Coufalik
Keyword(s):  
Organ Culture ◽  
Rat Liver ◽  
Fetal Rat ◽  
Fetal Rat Liver

Hormonal control of fructose 2,6-bisphosphate concentration and of phosphofructokinase 2 in the rat liver during development

1986 ◽  
Vol 6 (6) ◽  
pp. 513-518 ◽  
Author(s):  
Christian Schubert ◽  
Hans-Joachim Boehme ◽  
Eberhard Hofmann
Keyword(s):  
Rat Liver ◽  
Total Activity ◽  
Hormonal Control ◽  
Developmental Changes ◽  
Adrenal Hormones ◽  
Phosphorylation State ◽  
Exogenous Glucose ◽  
Substrate Supply ◽  
Fetal Rat ◽  
Fetal Rat Liver

In fetal rat liver the concentration of fructose 2,6-bisphosphate is decreased by administration of glucagon. The glucagon effect, i.e., the phosphorylation state of phosphofructokinase 2, dominates over the substrate supply. Insulin was found to increase fructose 2,6-bisphosphate only when exogenous glucose is supplied simultaneously. The total activity of phosphofructokinase 2 exhibits remarkable developmental changes. It is high at term, moderate in the fetal as well as in the mature organ, and low during suckling. The level of the enzyme during development is controlled by pancreatic and adrenal hormones.

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