Low Molecular Weight Proteinuria

2015 ◽  
pp. 156-162 ◽  
Author(s):  
Y. Manuel ◽  
A. Colle ◽  
M. Leclercq ◽  
C. Tonnelle
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Low Molecular Weight Proteinuria

Low concentrations of intravenous polygelines promote low-molecular weight proteinuria

2003 ◽  
Vol 33 (11) ◽  
pp. 962-968 ◽  
Author(s):  
B. A. J. Veldman ◽  
H. L. E. Schepkens ◽  
G. Vervoort ◽  
I. Klasen ◽  
J. F. M. Wetzels
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Low Molecular Weight Proteinuria ◽  
Low Concentrations

Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome

2007 ◽  
Vol 293 (2) ◽  
pp. F456-F467 ◽  
Author(s):  
Annalisa Vilasi ◽  
Pedro R. Cutillas ◽  
Anthony D. Maher ◽  
Severine F. M. Zirah ◽  
Giovambattista Capasso ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Fanconi Syndrome ◽  
Low Molecular Weight ◽  
Renal Fanconi Syndrome ◽  
Dent’S Disease ◽  
H Nmr ◽  
Low Molecular Weight Proteinuria ◽  
Dent's Disease ◽  
Underlying Mechanisms ◽  
Normal Urine

The renal Fanconi syndrome is a defect of proximal tubular function causing aminoaciduria and low-molecular-weight proteinuria. Dent's disease and Lowe syndrome are defined X-linked forms of Fanconi syndrome; there is also an autosomal dominant idiopathic form (ADIF), phenotypically similar to Dent's disease though its gene defect is still unknown. To assess whether their respective gene products are ultimately involved in a common reabsorptive pathway for proteins and low-molecular-mass endogenous metabolites, we compared renal Fanconi urinary proteomes and metabonomes with normal (control) urine using mass spectrometry and1H-NMR spectroscopy, respectively. Urine from patients with low-molecular-weight proteinuria secondary to ifosfamide treatment (tubular proteinuria; TP) was also analyzed for comparison. All four of the disorders studied had characteristic proteomic and metabonomic profiles. Uromodulin was the most abundant protein in normal urine, whereas Fanconi urine was dominated by albumin.1H-NMR spectroscopic data showed differences in the metabolic profiles of Fanconi urine vs. normal urine, due mainly to aminoaciduria. There were differences in the urinary metabolite and protein compositions between the three genetic forms of Fanconi syndrome: cluster analysis grouped the Lowe and Dent's urinary proteomes and metabonomes together, whereas ADIF and TP clustered together separately. Our findings demonstrate a distinctive “polypeptide and metabolite fingerprint” that can characterize the renal Fanconi syndrome; they also suggest that more subtle and cause-specific differences may exist between the different forms of Fanconi syndrome that might provide novel insights into the underlying mechanisms and cellular pathways affected.

scholarly journals Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria

2018 ◽  
Vol 27 (4) ◽  
pp. 392-395 ◽  
Author(s):  
Shpetim Salihu ◽  
Katerina Tosheska ◽  
Svetlana Cekovska ◽  
Velibor Tasic
Keyword(s):  
Molecular Weight ◽  
Sodium Dodecyl Sulfate ◽  
Clinical Presentation ◽  
Viral Infections ◽  
Sodium Dodecyl ◽  
Febrile Illness ◽  
Low Molecular Weight ◽  
Acute Febrile Illness ◽  
Low Molecular Weight Proteinuria ◽  
Sds Page

Objective: Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection. Clinical Presentation and Intervention: In this report, we present a patient who was thought to have febrile proteinuria. Persistence of significant proteinuria after resolution of the infection prompted biochemical and genetic workup which led to the diagnosis of Dent-2 disease. Conclusion: We recommend the use of SDS-PAGE (sodium dodecyl sulfate electropheresis) for the detection of low molecular weight proteinuria.

Hypercalciuria and Nephrocalcinosis in Patients with Idiopathic Low-Molecular-Weight Proteinuria in Japan: Is the Disease Identical to Dent’s Disease in United Kingdom?

Nephron ◽  
1995 ◽  
Vol 69 (3) ◽  
pp. 242-247 ◽  
Author(s):  
Takashi Igarashi ◽  
Hiroshi Hayakawa ◽  
Hiroshi Shiraga ◽  
Hidehiko Kawato ◽  
Kunimasa Yan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
United Kingdom ◽  
Low Molecular Weight ◽  
Dent’S Disease ◽  
Low Molecular Weight Proteinuria ◽  
Dent's Disease

scholarly journals Mutations in the CLCN5 gene in Japanese patients with familial idiopathic low-molecular-weight proteinuria

1997 ◽  
Vol 52 (4) ◽  
pp. 895-900 ◽  
Author(s):  
Hitoshi Nakazato ◽  
Shinzaburo Hattori ◽  
Akio Furuse ◽  
Tomoyasu Kawano ◽  
Shinnyo Karashima ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Japanese Patients ◽  
Low Molecular Weight ◽  
Clcn5 Gene ◽  
Low Molecular Weight Proteinuria

scholarly journals Analysis in the CLCN5 gene in patients with familial idiopathic low-molecular-weight proteinuria.

1998 ◽  
Vol 11 (2) ◽  
pp. 177-180
Author(s):  
Hitoshi Nakazato ◽  
Shinzaburo Hattori ◽  
Junichiro Yoshimuta ◽  
Akio Furuse ◽  
Shinnyo Karashima ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Clcn5 Gene ◽  
Low Molecular Weight Proteinuria

scholarly journals Chloride channel CLCN5 mutations in Japanese children with familial idiopathic low molecular weight proteinuria

1999 ◽  
Vol 55 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Hitoshi Nakazato ◽  
Junichiro Yoshimuta ◽  
Shinnyo Karashima ◽  
Shinichi Matsumoto ◽  
Fumio Endo ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chloride Channel ◽  
Low Molecular Weight ◽  
Japanese Children ◽  
Low Molecular Weight Proteinuria ◽  
Clcn5 Mutations

Holoprosencephaly and low molecular weight proteinuria: The human homologue of murine megalin deficiency

2001 ◽  
Vol 37 (3) ◽  
pp. 624-628 ◽  
Author(s):  
Dominik Müller ◽  
Tobias Ankermann ◽  
Ulrich Stephani ◽  
Martin Kirschstein ◽  
Tamas Szelestei ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Human Homologue ◽  
Low Molecular Weight Proteinuria
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