A Genetic Study of Plasma Dopamine �-Hydroxylase in Affective Disorder

2015 ◽  
pp. 89-98 ◽  
Author(s):  
Morton Levitt ◽  
Julien Mendlewicz
Keyword(s):  
Affective Disorder ◽  
Genetic Study

A Genetic Study of Bipolar Affective Disorder

1975 ◽  
Vol 126 (5) ◽  
pp. 449-456 ◽  
Author(s):  
N. MeI. James ◽  
C. J. Chapman
Keyword(s):  
Mental Disorder ◽  
Affective Disorder ◽  
Assortative Mating ◽  
Genetic Study ◽  
Bipolar Affective Disorder ◽  
High Rate ◽  
Polygenic Inheritance ◽  
First Degree Relatives

SummaryA group of 46 bipolar probands and their first degree relatives were studied. A high rate of affective disorder (19.6 per cent) was found, including both unipolar (13.2 per cent) and bipolar (6.4 per cent) types, with females predominating (3: 1). The presence of four father-son pairs suffering from affective disorder made the hypothesis of X-linked dominance untenable. Results compatible with polygenic inheritance were found, using both Slater's and Falconer's methods. There was no evidence for assortative mating or for increased total number of females (both well and ill) among first degree relatives. The probands and affectively ill first degree relatives who have died show an alarmingly high rate of suicide (46 per cent). Other forms of mental disorder, including alcoholism, were no more common than in the rest of the community.

Genetic study of dopamine-related genes in unipolar affective disorder

1998 ◽  
Vol 8 ◽  
pp. S190
Author(s):  
G.N. Papadimitriou ◽  
D.G. Dikeos ◽  
G. Karadima ◽  
E.G. Daskalopoulou ◽  
D. Avramopoulos ◽  
...  
Keyword(s):  
Affective Disorder ◽  
Genetic Study
Sign in / Sign up

Export Citation Format

Share Document