Relationship of Genetic Factors to Course and Drug Response in Schizophrenia, Mania and Depression1

2015 ◽  
pp. 1-11 ◽  
Author(s):  
George Winokur
Keyword(s):  
Drug Response ◽  
Genetic Factors ◽  
Relationship Of

Invited Review: Pharmacogenetics of estrogen replacement therapy

2001 ◽  
Vol 91 (6) ◽  
pp. 2776-2784 ◽  
Author(s):  
David M. Herrington ◽  
Karen Potvin Klein
Keyword(s):  
Estrogen Replacement Therapy ◽  
Genetic Factors ◽  
Estrogen Receptor Α ◽  
Estrogen Replacement ◽  
Risk Gene ◽  
Thrombosis Risk ◽  
Venous Thromboembolic Events ◽  
Venous Thromboembolic ◽  
Relationship Of ◽  
The Relationship

There are a number of genetic factors that likely modulate both the beneficial and adverse effects of estrogen. An important domain of consideration is the relationship of estrogen and thrombosis risk. Gene polymorphisms among the key elements of the coagulation and fibrinolytic cascade appear to influence the effects of estrogen on risk for venous thromboembolic events and possibly arterial thrombosis as well. Emerging data also suggest that allelic variants in the estrogen receptor-α may modulate estrogen's effects, especially with respect to bone and lipid metabolism.

RELATIONSHIP OF TAXA IN THE GENUS MEDICAGO AS REVEALED BY HYBRIDIZATION. I. M. STRIATA × M. LITTORALIS

1968 ◽  
Vol 10 (2) ◽  
pp. 263-275 ◽  
Author(s):  
K. Lesins ◽  
A. Erac
Keyword(s):  
High Mortality ◽  
Genetic Factor ◽  
Genetic Factors ◽  
Chromosomal Rearrangements ◽  
Cytoplasmic Factor ◽  
Reciprocal Crosses ◽  
Gross Chromosomal Rearrangements ◽  
Coiling Direction ◽  
Chlorophyll Deficiencies ◽  
Relationship Of

In crosses between the two taxa Medicago striata Bast, and M. littoralis Rohde a high mortality of gametes and seedlings, and sterility of some plants were noted which were not related to gross chromosomal rearrangements. Although the F1, F2 and F3 generations from reciprocal crosses differed in chlorophyll deficiencies (indicating a cytoplasmic influence) a genic cause became evident from segregations for chlorophyll characters in the F2 and F3. Transference of the cytoplasmic factor by the pollen is indicative.Segregation for pod coiling direction indicated that the character was determined by one or two genetic factors of which the clockwise coiling direction is recessive. The spininess appeared to be determined by one genetic factor, of which the spineless allele is recessive.On the basis of genetic differences (especially on the built-in repulsion systems for normal chlorophyll development of opposite species) the two taxa should be considered two different species.

scholarly journals The relationship of genetic factors to the development of nephrolithiasis in primary hyperparathyroidism

2015 ◽  
Author(s):  
Elena Peretokina ◽  
Natalia Mokrysheva ◽  
Lyudmila Rozhinskaya ◽  
Ekaterina Zakharova
Keyword(s):  
Primary Hyperparathyroidism ◽  
Genetic Factors ◽  
Relationship Of ◽  
The Relationship

Genetic influence on normal variability of maximum expiratory flow-volume curves

1976 ◽  
Vol 41 (6) ◽  
pp. 874-877 ◽  
Author(s):  
S. F. Man ◽  
N. Zamel
Keyword(s):  
Genetic Factors ◽  
Genetic Influence ◽  
Identical Twins ◽  
Flow Volume ◽  
Peripheral Airways ◽  
Normal Individuals ◽  
Maximum Expiratory Flow ◽  
Large Airways ◽  
Expiratory Flow ◽  
Relationship Of

To determine the importance of genetic influence on the variability of maximum expiratory flow-volume (MEFV) curves in normal individuals, MEFV curves breathing air and a mixture of 80% helium and 20% oxygen (He-O2), lung volumes, specific airway conductance, and closing capacity (CC) were obtained in 10 pairs of identical and 6 pairs of nonidentical twins, all nonsmokers and asymptomatic. For a given pair of identical twins, MEFV curves on air were more similar than those of a pair of nonidentical twins (P less than0.02). The intrapair differences of identical twins were smaller than nonidentical twins of maximum expiratory flow (Vmax) at 60% of total lung capacity (TLC) on air (P less than 0.001) and on He-O2 (P less than 0.01). However, intrapair differences of Vmax at 40% TLC and CC were not significantly different in the two groups. Since Vmax at 60% TLC on air and He-O2 are dependent on the geometry of large airways these findings are suggestive that the geometry of large airways may be related to genetic factors. The relationship of the geometry of the peripheral airways and genetic factors has notbeen defined.

Lifetime prevalence of mood and anxiety disorders in twin pairs discordant for schizophrenia

Twin Research ◽  
2000 ◽  
Vol 3 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Michael J Lyons ◽  
Jonathan Huppert ◽  
Rosemary Toomey ◽  
Rebecca Harley ◽  
Jack Goldberg ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Anxiety Disorders ◽  
Genetic Factors ◽  
Statistical Significance ◽  
Monozygotic Twins ◽  
Twin Registry ◽  
Mood And Anxiety Disorders ◽  
Vietnam Era ◽  
Relationship Of ◽  
The Relationship

AbstractThere have been long questions about the relationship of schizophrenia to other mental disorders. Lifetime DSM-III-R diagnoses of mood and anxiety disorders in twins with clinically diagnosed schizophrenia (n = 24) and their non-affected co-twins (n = 24) were compared with twins from pairs without schizophrenia (n = 3327) using a sample from the Vietnam Era Twin Registry. Schizophrenic probands had significantly elevated rates of all included disorders (bipolar disorder, major depression, dysthymia, generalized anxiety disorder, panic disorder, and PTSD) compared with controls (P < 0.01). The odd ratios comparing co-twins of schizophrenic probands with controls was greater than three for every disorder, but did not attain statistical significance. A similar pattern was observed when analyses were restricted to only monozygotic twins (n = 12). Consistent with other studies, schizophrenics appeared to have higher rates of a range of mental disorders. Our results suggest that schizophrenia per se represents a risk factor for other psychiatric disorders, but the absence of significantly elevated risk among non-schizophrenic co-twins suggested that family environmental and/or genetic factors that contribute to risk of schizophrenia do not increase the risk of mood and anxiety disorders to the same extent that the risk of these other disorders is increased by the presence of schizophrenia. Twin Research (2000) 3, 28–32.

scholarly journals SUN-580 PCSK9 and Lp(a): Association Between PCSK9 Level and Larger Apo(a) Isoform Size in African-Americans and Caucasians

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Enkhmaa Byambaa ◽  
Kyoungmi Kim ◽  
Wei Zhang ◽  
Kevin Truax ◽  
Anuurad Erdembileg ◽  
...  
Keyword(s):  
African Americans ◽  
Genetic Factors ◽  
African American Families ◽  
Apolipoprotein A ◽  
Causal Risk Factor ◽  
The Mean ◽  
Race Ethnicity ◽  
Age Range ◽  
Relationship Of ◽  
The Relationship

Abstract Introduction: An elevated level of lipoprotein(a) [Lp(a)] is an independent causal risk factor for cardiovascular disease. Non-genetic factors do not appreciably influence Lp(a) levels due to a strong genetic control. However, inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to reduce Lp(a) levels. The association of PCSK9 with Lp(a) level and its major genetic determinant—apolipoprotein(a) [apo(a)] size—is not fully understood. In this study, we assessed the relationship between PCSK9, Lp(a) level, apo(a) size, age, and race/ethnicity. Methods: Healthy Caucasian and African-American families were recruited from the general population (age range: 6–74 years, N=267). PCSK9 and Lp(a) levels were assayed enzymatically; apo(a) isoform and LPA allele sizes and isoform-specific Lp(a) levels were determined. Results: In all participants, PCSK9 levels differed significantly by race/ethnicity, age, and sex. Thus, the mean PCSK9 levels were significantly higher in African-Americans vs. Caucasians (104 ± 29 vs. 95 ± 30 ng/mL, respectively, p=0.020), in adults vs. children (102 ± 29 vs. 92 ± 31 ng/mL, respectively, p=0.001) and in females vs. males (103 ± 30 vs. 94 ± 29 ng/mL, respectively, p=0.007). PCSK9 levels were not associated with total plasma Lp(a) levels neither in all participants nor in ethnicity-specific analyses. However, PCSK9 levels were significantly and positively associated with isoform-specific Lp(a) levels carried by the larger apo(a) size in all subjects (r=0.139, p=0.0361). In race/ethnicity analyses, a significant association was seen for African-Americans (r=0.268, p=0.0199), but not for Caucasians. In contrast, there were no significant associations of PCSK9 with isoform-specific Lp(a) levels for the smaller apo(a) sizes in all participants nor in ethnic-specific analyses. Of note, PCSK9 levels were significantly negatively associated with the larger apo(a) isoform sizes in all participants (r=-0.139, p=0.0366). Although significant in both groups, heritability of PCSK9 level was higher in Caucasians than in African-Americans (47% vs. 22%, respectively). Conclusions: Among African-Americans, but not Caucasians, PCSK9 levels were associated with isoform-specific Lp(a) levels carried on larger, but not smaller, apo(a) sizes. The findings illustrate a diverging relationship of PCSK9 with isoform-specific Lp(a) levels.

scholarly journals HUBUNGAN TINGKAT STRES TERHADAP PENINGKATAN KADAR GULA DARAH PADA PASIEN DM TIPE II DI RSU. ROYAL PRIMA MEDAN

2020 ◽  
Vol 3 (1) ◽  
pp. 39
Author(s):  
Tiarnida Nababan ◽  
Karmila Br Kaban ◽  
Eva Latifah Nurhayati
Keyword(s):  
Blood Sugar ◽  
Genetic Factors ◽  
The Body ◽  
Type Ii ◽  
Elevated Blood ◽  
Chi Square ◽  
High Blood Glucose ◽  
Sample Number ◽  
Sugar Levels ◽  
Relationship Of

Diabetes mellitus is the result of the interaction of genetic factors and environmental exposure. Genetic factors will determine the individuals susceptible to DM.Uncontrolled diabetes and over time cause serious damage to many systems of the body, especially the nerves and blood vessels. By 2014, 8.5% of adults 18 years and over have diabetes. By 2015, diabetes is a direct cause of 1.6 million deaths and by 2012 high blood glucose is the cause of 2.2 million other deaths. This study aims to determine the relationship of stress levels to elevated blood sugar levels in patients with type II DM in Royal Prima Hospytal Medan. The research design used is correlation (Correlation Study) with Cross Sectional approach. The sample of this research is patient of DM type II disease with sample number 67 respondent using chi-square statistic test. Based on chi-square statistic test can be obtained result of 0,04 that is <0,05 means smaller than value α = 0,05. Thus drawn conclusion there is a relationship of stress level to increase blood sugar levels in DM tipe II patients in Royal Prima Hospytal Medan. From the results of the study concluded that there is a relationship level of stress to elevated blood sugar levels in patients DM tipe II. Suggested to Royal Prima Hospytal Medan recommends that patients keep control of stress on natural problems and diseases in order not to lead to other forms of disease.

scholarly journals Predicting of fentanyl-associated neurotoxicity in pancreatic cancer with clical, genetic model

2021 ◽  
pp. 136-145
Author(s):  
O. P. Bobrova ◽  
N. A. Shnayder ◽  
M. M. Petrova ◽  
S. N. Zobova ◽  
Yu. A. Dykhno ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Personalized Medicine ◽  
Genetic Factors ◽  
Genetic Model ◽  
Clinical Genetic ◽  
Relationship Of ◽  
The Relationship

Aim. To develop a model for the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer based on an analysis of the relationship of clinical and genetic factors. Materials and methods. In 45 patients with pancreatic cancer, 54 clinical and genetic factors were studied for predicting the implementation of opioid-associated neurotoxicity, receiving a transdermal form of fentanyl. Results. A clinical genetic model of the implementation of opioid - associated neurotoxicity in patients with pancreatic cancer was developed using the example of a transdermal form of fentanyl Conclusion. The clinical genetic model for predicting the risk of opioid-associated neurotoxicity in patients with pancreatic cancer is important from the perspective of personalized medicine.

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