Telemetry of Radionuclide Tracers by Implantable Thermoluminescent Dosimeters on Rats

2015 ◽  
pp. 43-45
Author(s):  
J�rgen Bojsen ◽  
Ulla M�ller ◽  
Poul Christensen ◽  
J�rgen Lippert
Keyword(s):  
Thermoluminescent Dosimeters ◽  
Radionuclide Tracers

Storage telemetry of radionuclide tracers by implantable thermoluminescent dosimeters.

1977 ◽  
Vol 233 (6) ◽  
pp. E479
Author(s):  
J Bojsen ◽  
U Moller ◽  
P Christensen ◽  
J Lippert
Keyword(s):  
Tumor Tissue ◽  
Relative Uncertainty ◽  
Experimental Conditions ◽  
Thermoluminescent Dosimeters ◽  
Beta Emitters ◽  
Temperature Rhythm ◽  
Radionuclide Tracers ◽  
Silicon Tube ◽  
Subcutaneous Tissues

A storage telemetrical method using thermoluminescent (TL) dosimeters for long-term measurements of incorporated radioactive substances in unrestrained rats has been developed. The system has been used in combination with radiotelemetrical registration of the circadian temperature rhythm. By sequential replacement of double TL dosimeters (60 mg, CaSO4:Dy) through an implanted silicon tube, the concentration of different radionuclides can be determined over long periods. The persistence of the circadian temperature rhythm indicates that the animals were unaffected by the experimental conditions. The relative uncertainty of the dosimeter system and the temperature transmitter is approximately +/- 2% (SD) at 5 mR exposures and +/- 0.05 degrees C, respectively. The weight of the system in total is 5.7 g. Disappearance studies (36-48 h) have been performed with the beta-emitters, 32P nad 42K, in subcutaneous tissues and tumor tissue. This TL method permits the repetition of an experiment on the same rat several times, and thereby avoids errors due to biological variations between animals.

scholarly journals Estimation of dose and cancer risk to newborn from chest X-ray in South-South Nigeria: a call for protocol optimization

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Akintayo Daniel Omojola ◽  
Michael Onoriode Akpochafor ◽  
Samuel Olaolu Adeneye ◽  
Isiaka Olusola Akala ◽  
Azuka Anthonio Agboje
Keyword(s):  
Cancer Risk ◽  
Age Groups ◽  
Field Size ◽  
Radiological Protection ◽  
International Studies ◽  
X Ray ◽  
Thermoluminescent Dosimeters ◽  
Chest X Ray ◽  
Neonatal Patient ◽  
The Mean

Abstract Background The use of X-ray as a diagnostic tool for complication and anomaly in the neonatal patient has been helpful, but the effect of radiation on newborn stands to increase their cancer risk. This study aims to determine the mean, 50th percentile (quartile 2 (Q2)), and 75th percentile (quartile 3 (Q3)) entrance surface dose (ESD) from anteroposterior (AP) chest X-ray and to compare our findings with other relevant studies. The study used calibrated thermoluminescent dosimeters (TLDs), which was positioned on the central axis of the patient. The encapsulated TLD chips were held to the patients’ body using paper tape. The mean kilovoltage peak (kVp) and milliampere seconds (mAs) used was 56.63(52–60) and 5.7 (5–6.3). The mean background TLD counts were subtracted from the exposed TLD counts and a calibration factor was applied to determine ESD. Results The mean ESDs of the newborn between 1 and 7, 8 and 14, 15 and 21, and 22 and 28 days were 1.09 ± 0.43, 1.15 ± 0.50, 1.19 ± 0.45, and 1.32 ± 0.47 mGy respectively. A one-way ANOVA test shows that there were no differences in the mean doses for the 4 age groups (P = 0.597). The 50th percentile for the 4 age groups was 1.07, 1.26, 1.09, and 1.29 mGy respectively, and 75th percentile were 1.41, 1.55, 1.55, and 1.69 mGy respectively. The mean effective dose (ED) in this study was 0.74 mSv, and the estimated cancer risk was 20.7 × 10−6. Conclusion ESD was primarily affected by the film-focus distance (FFD) and the patient field size. The ESD at 75th percentile and ED in this study was higher compared to other national and international studies. The estimated cancer risk to a newborn was below the International Commission on Radiological Protection (ICRP) limit for fatal childhood cancer (2.8 × 10−2Sv−1).

Use of the Leksell Gamma Knife for Localized Small Field Lens Irradiation in Rodents

2003 ◽  
Vol 2 (5) ◽  
pp. 449-454 ◽  
Author(s):  
Colleen DesRosiers ◽  
Marc S. Mendonca ◽  
Craig Tyree ◽  
Vadim Moskvin ◽  
Morris Bank ◽  
...  
Keyword(s):  
Gamma Knife ◽  
High Precision ◽  
Small Animal ◽  
Small Animals ◽  
Small Field ◽  
Thermoluminescent Dosimeters ◽  
Ion Chamber ◽  
Order Of Magnitude ◽  
Contralateral Eye

For most basic radiobiological research applications involving irradiation of small animals, it is difficult to achieve the same high precision dose distribution realized with human radiotherapy. The precision for irradiations performed with standard radiotherapy equipment is ±2 mm in each dimension, and is adequate for most human treatment applications. For small animals such as rodents, whose organs and tissue structures may be an order of magnitude smaller than those of humans, the corresponding precision required is closer to ±0.2 mm, if comparisons or extrapolations are to be made to human data. The Leksell Gamma Knife is a high precision radiosurgery irradiator, with precision in each dimension not exceeding 0.5 mm, and overall precision of 0.7 mm. It has recently been utilized to treat ocular melanoma and induce targeted lesions in the brains of small animals. This paper describes the dosimetry and a technique for performing irradiation of a single rat eye and lens with the Gamma Knife while allowing the contralateral eye and lens of the same rat to serve as the “control”. The dosimetry was performed with a phantom in vitro utilizing a pinpoint ion chamber and thermoluminescent dosimeters, and verified by Monte Carlo simulations. We found that the contralateral eye received less than 5% of the administered dose for a 15 Gy exposure to the targeted eye. In addition, after 15 Gy irradiation 15 out of 16 animals developed cataracts in the irradiated target eyes, while 0 out of 16 contralateral eyes developed cataracts over a 6-month period of observation. Experiments at 5 and 10 Gy also confirmed the lack of cataractogenesis in the contralateral eye. Our results validate the use of the Gamma Knife for cataract studies in rodents, and confirmed the precision and utility of the instrument as a small animal irradiator for translational radiobiology experiments.

Thin sintered Al2O3 pellets as thermoluminescent dosimeters for the therapeutic dose range

2003 ◽  
Vol 58 (6) ◽  
pp. 719-722 ◽  
Author(s):  
Felı́cia D.G. Rocha ◽  
Mércia L. Oliveira ◽  
Linda V.E. Caldas
Keyword(s):  
Therapeutic Dose ◽  
Dose Range ◽  
Thermoluminescent Dosimeters ◽  
Therapeutic Dose Range

Ionizing radiation and its considerations in imaging diagnosis: comparison of absorbed dose between cone beam computed tomography and multi-detector computed tomography in the head and neck

2021 ◽  
Author(s):  
P.L.E. Oliveira ◽  
C.R. Starling ◽  
C.L.P. Maurício ◽  
F.R. Guedes ◽  
M.A. Visconti ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Head And Neck ◽  
Cone Beam Computed Tomography ◽  
Absorbed Dose ◽  
Cone Beam ◽  
Thermoluminescent Dosimeters ◽  
Organ Tissue ◽  
The Mean ◽  
Average Adult ◽  
Multi Detector Computed Tomography

Introduction: The objective of this study was to compare the mean absorbed dose in patients undergoing head and neck examinations using two cone beam computed tomography (CBCT, Kodak and i-CAT) and one multi-detector computed tomography (MDCT). Methods: Three thermoluminescent dosimeters (TLDs), calibrated in air kerma, were positioned in 24 regions of the head and neck of a phantom simulating an average adult. The mean absorbed dose (mGy) values in these positions, for different organs and tissues, were obtained using correction factors, considering the ratio between the mass energy absorption coefficients of organ/tissue and air. Comparison between radiation doses in the most radiosensitive regions was done by calculating the ratio of these dose values, with propagated uncertainty. Results: The dose in all regions was significantly higher for MDCT when compared to CBCT. Concerning CBCT equipment, the Kodak device had a higher absorbed dose than the i-CAT for most of the regions tested. The uncertainty of the i-CAT was greater than that of the Kodak. Conclusion: Due to the considerable difference between absorbed doses, emphasizing the higher dose values obtained in MDCT, the dissemination of CBCT application in medicine is recommended, as well as further studies to broaden the criteria for use.

scholarly journals Intraoperative 2D C-arm and 3D O-arm in children: a comparative phantom study

2018 ◽  
Vol 12 (5) ◽  
pp. 550-557 ◽  
Author(s):  
M. Prod’homme ◽  
M. Sans-Merce ◽  
N. Pitteloud ◽  
J. Damet ◽  
P. Lascombes
Keyword(s):  
Radiation Exposure ◽  
Scattered Radiation ◽  
Intraoperative Imaging ◽  
Radiation Doses ◽  
Organ Doses ◽  
Thermoluminescent Dosimeters ◽  
Dose Rates ◽  
Absorbed Doses ◽  
Entrance Dose ◽  
Student’S T

Purpose Exposure to ionizing radiation is a concern for children during intraoperative imaging. We aimed to assess the radiation exposure to the paediatric patient with 2D and 3D imaging. Methods To evaluate the radiation exposure, patient absorbed doses to the organs were measured in an anthropomorphic phantom representing a five-year-old child, using thermoluminescent dosimeters. For comparative purposes, organ doses were measured using a C-arm for one minute of fluoroscopy and one acquisition with an O-arm. The cone-beam was centred on the pelvis. Direct and scattered irradiations were measured and compared (Student’s t-test). Skin entrance dose rates were also evaluated. Results All radiation doses were expressed in µGy. Direct radiation doses of pelvic organs were between 631.22 and 1691.87 for the O-arm and between 214.08 and 737.51 for the C-arm, and were not significant (p = 0.07). Close scattered radiation on abdominal organs were between 25.11 and 114.85 for the O-arm and between 8.03 and 55.34 for the C-arm, and were not significant (p = 0.07). Far scattered radiation doses on thorax, neck and head varied from 0.86 to 6.42 for the O-arm and from 0.04 to 3.08 for the C-arm, and were significant (p = 0.02). The dose rate at the skin entrance was 328.58 µGy.s−1 for the O-arm and 1.90 with the C-arm. Conclusion During imaging of the pelvis, absorbed doses for a 3D O-arm acquisition were higher than with one minute fluoroscopy with the C-arm. Further clinical studies comparing effective doses are needed to assess ionizing risks of the intraoperative imaging systems in children.

Deriving hillslope sediment budgets in wildfire-affected forests using fallout radionuclide tracers

Geomorphology ◽  
2009 ◽  
Vol 104 (3-4) ◽  
pp. 105-116 ◽  
Author(s):  
W.H. Blake ◽  
P.J. Wallbrink ◽  
S.N. Wilkinson ◽  
G.S. Humphreys ◽  
S.H. Doerr ◽  
...  
Keyword(s):  
Sediment Budgets ◽  
Radionuclide Tracers ◽  
Fallout Radionuclide
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