Suppression of Production of Epstein-Barr Virus in P3HR-1 Cell Line by Bovine Serum

2015 ◽  
pp. 589-591
Author(s):  
Yorio Hinuma ◽  
Takeshi Sairenji
Keyword(s):  
Cell Line ◽  
Bovine Serum ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

Early exposure to interleukin-21 limits rapidly generated anti–Epstein-Barr virus T-cell line differentiation

Cytotherapy ◽  
2015 ◽  
Vol 17 (4) ◽  
pp. 496-508 ◽  
Author(s):  
Julie Orio ◽  
Cédric Carli ◽  
Valérie Janelle ◽  
Martin Giroux ◽  
Julie Taillefer ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
Epstein Barr Virus ◽  
Early Exposure ◽  
Barr Virus ◽  
Interleukin 21 ◽  
Epstein Barr

scholarly journals Oncogenic Role of Epstein-Barr Virus-Encoded RNAs in Burkitt’s Lymphoma Cell Line Akata

1999 ◽  
Vol 73 (12) ◽  
pp. 9827-9831 ◽  
Author(s):  
Jun Komano ◽  
Seiji Maruo ◽  
Koichi Kurozumi ◽  
Takanori Oda ◽  
Kenzo Takada
Keyword(s):  
Cell Line ◽  
Small Rnas ◽  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Soft Agar ◽  
Burkitt's Lymphoma ◽  
Malignant Phenotype ◽  
Barr Virus ◽  
Epstein Barr

ABSTRACT Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt’s lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069–6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150–9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.

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