Quantitative Studies on the Motor End Plate

2015 ◽  
pp. 148-153
Author(s):  
M. V. Salmon
Keyword(s):  
End Plate ◽  
Quantitative Studies ◽  
Motor End Plate

Experimental neonatal autoimmune myasthenia gravis: an immunohistochemical, ultrastructural and electrophysiological study of the motor end-plate

1995 ◽  
Vol 132 (2) ◽  
pp. 97-104
Author(s):  
Naoko Tetsuo ◽  
Mitsuhiro Tsujihata ◽  
Akira Satoh ◽  
Toshiro Yoshimura ◽  
Tatsufumi Nakamura ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Electrophysiological Study ◽  
End Plate ◽  
Motor End Plate ◽  
Autoimmune Myasthenia

A study of the effect of X-rays on the electrical properties of mammalian nerve and muscle

1963 ◽  
Vol 157 (969) ◽  
pp. 536-561 ◽  
Keyword(s):  
Dose Rate ◽  
Action Potentials ◽  
Time Course ◽  
Low Dose ◽  
High Dose ◽  
X Rays ◽  
Low Dose Rate ◽  
End Plate ◽  
Small Doses ◽  
Motor End Plate

Resting potentials, action potentials, and miniature end-plate potentials have been re­corded from isolated phrenic-diaphragm preparations of the rat during and after irradiation with X-rays. Relatively small doses of a few thousand roentgens have no obvious effect on the preparation for many hours but larger doses, of the order of 70 to 150 kr irreversibly block neuromuscular transmission. The block is not accompanied by any change in the size of action potentials, resting potentials, membrane constants or miniature potentials recorded in the muscle with intracellular electrodes, or in the size of action potentials recorded in the nerve. Records made at the motor end-plate show that the cause of the block is a ‘pre-synaptic ’ failure of impulse propagation in the intramuscular part of the nerve. The time course of the failure depends largely on the rate at which X-rays are delivered to the pre­paration: at a high dose-rate (70kr/min) the block develops rapidly and is accompanied by an increase in the frequency of miniature potentials; at a low dose-rate (7 kr/min) larger doses are required, the latency is longer and the miniature potentials continue at a normal frequency. The sequence in which different parts of the muscle become blocked, the abrupt nature of the failure at an individual motor end-plate, and the increase in frequency of the miniature potentials together suggest that the action of X-rays is to block conduction in the nerve near its terminals, possibly by depolarizing points where the axons branch and the safety factor for the propagation of impulses is low. The results reported in this paper do not support the hypotheses that small doses of X-rays at a high or a low dose-rate lead to an initial 'enhancement' of function or that they produce immediate and reversible changes in the permeability of excitable membranes to ions.

Dysfunction at the motor end-plate and axon membrane in Guillain-Barré syndrome: A single-fiber EMG study

2003 ◽  
Vol 27 (4) ◽  
pp. 426-434 ◽  
Author(s):  
Frank Spaans ◽  
Jan-Willem Vredeveld ◽  
Humphrey H.E. Morré ◽  
Bart C. Jacobs ◽  
Marc H. De Baets
Keyword(s):  
Single Fiber ◽  
Guillain Barre Syndrome ◽  
Axon Membrane ◽  
End Plate ◽  
Guillain Barré Syndrome ◽  
Motor End Plate ◽  
Guillain Barré

Effects of long-term administration of ambenonium chloride on motor end-plate fine structure and acetylcholine receptor in rat

1981 ◽  
Vol 51 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Ryuji Hazama ◽  
Mitsuhiro Tsujihata ◽  
Masataka Mori ◽  
Masaharu Takamori ◽  
Kazutake Mori ◽  
...  
Keyword(s):  
Fine Structure ◽  
Acetylcholine Receptor ◽  
End Plate ◽  
Motor End Plate ◽  
Term Administration

scholarly journals Panel II on the Therapies of the Depressive Illnesses Tendon Reflexes as a Guide to the Safe use of Succinylcholine in Medicine

1966 ◽  
Vol 11 (1_suppl) ◽  
pp. 67-77
Author(s):  
J. Impastato David
Keyword(s):  
Nerve Impulse ◽  
Test Dose ◽  
Congenital Absence ◽  
Biochemical Reactions ◽  
Convulsive Therapy ◽  
End Plate ◽  
Tendon Reflex ◽  
Motor End Plate ◽  
Natural Variations ◽  
Tendon Reflexes

Familiarity with certain physiologic and biochemical reactions and factors of succinylcholine (SCh) in man is helpful in safely administering SCh in convulsive therapy and anesthesiology. These reactions and factors are: 1) the natural variations in the titer of butyrylcholinesterase (BChE) in the plasma, 2) the interactions between SCh with BChE, 3) the action of SCh in the congenital absence of BChE, 4) understanding of the mechanism of transmission of the nerve impulse, 5) the action of succinylcholine at the motor end plate. Discussion of the above reactions and factors are presented. Two physiologic tests are described. These are the 3 mg SCh test dose and the tendon reflex test. The proper application of these two tests make possible the safest use of succinylcholine in convulsive therapy, as well as in other fields of medicine.

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