Clinical Significance of Urinary Albumin Dimers in the Nephrotic Syndrome

2015 ◽  
pp. 72-77 ◽  
Author(s):  
J. Hardwicke
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Significance ◽  
Urinary Albumin

scholarly journals May be Urinary Excretion of α2-macroglobulin (MW 720 kDa) a Proteinuric Marker of Podocytopathy? Insight from Analysis of 204 Patients with Glomerulonephritis (GN) and Nephrotic Syndrome, 177 with Functional Outcome

2021 ◽  
Vol 8 (3) ◽  
pp. 01-06
Author(s):  
Claudio Bazzi
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Practice ◽  
Urinary Excretion ◽  
Functional Outcome ◽  
Clinical Significance ◽  
Α2 Macroglobulin ◽  
Progression Risk ◽  
Treatment Responsiveness

Background: In IgAN with cellular crescents (CIgAN) urinary excretion of α2-macroglobulin (α2m/C, MW 720 kDa) may be a marker of podocytes damage induced by crescents. The purpose of the study was the evaluation of the clinical significance of α2m/C excretion in 177 patients with glomerulonephritis (GN), nephrotic syndrome (NS) and functional outcome. Methods: In all 177 patients α2m/C excretion was measured; the patients were divided in 2 groups: α2mC=0 (n. 72) and α2m/C >0 (n. 105); for each group were assessed the outcomes considered in combination: Remission & persistent nephrotic syndrome (PNS) with long lasting NRF designed “Remission & NRF”; ESRD & eGFR < 50% & PNS with CRF designed “Progression and progression risk”. Results: In 72 patients with α2m/C=0 “Remission & NRF” was 78% and “Progression & progression risk” was 22%; in 105 patients with α2m/C>0 “remission & NRF” was 52% and “Progression & progression risk” was 48%. “Remission & NRF” in each GN type with α2m/C=0 was: 100% in MCD and LN; 82%, 79%, 67% in FSGS, IMN, MPGN; in α2m/C>0 “Progression and progression risk” was 0%, 38%, 46%, 54%, 56%, 85% in MCD, LN, IMN, MPGN, FSGS, CIgAN with cellular crescents, respectively. Conclusion: Urinary excretion of α2m is a very simple marker available in all clinical practice laboratories, marker of damage of podocytes at least in CIgAN and LN with crescents and marker of GFB damage in different GN types and useful to predict outcome and treatment responsiveness.

Clinical Electron Microscopy of the Glomerulus in Human Renal Disease

1969 ◽  
Vol 27 ◽  
pp. 208-209
Author(s):  
R. V. Weimer ◽  
C. E. Rupe ◽  
J. H. L. Watson
Keyword(s):  
Electron Microscopy ◽  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Basement Membrane ◽  
Renal Disease ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Significant Contribution ◽  
Systemic Lupus ◽  
Glomerular Lesions

Electron microscopy of the glomerulus in human renal disease has yielded much data of clinical significance. Two predominant classifications of glomerular pathology are met: proliferative and membranous transformations. The latter is further divisible into those with or without deposits, usually associated with the capillary basement membrane BM. A precise ultrastructural classification would be a significant contribution to diagnosis. Seven of the classical glomerular lesions will be presented. The figures represent four of them. Three others will also be given in the demonstration viz. "Systemic" Lupus Erythematosus, Amyloidosis and The Nephrotic Syndrome.

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