Single Breath Diffusion Capacity for Carbon Monoxide in Bronchial Asthma and Emphysema1

2015 ◽  
pp. 147-151 ◽  
Author(s):  
H. Magnussen
Keyword(s):  
Carbon Monoxide ◽  
Bronchial Asthma ◽  
Diffusion Capacity ◽  
Single Breath

scholarly journals New standards for measuring the diffusion capacity of the lungs by carbon monoxide by single breath method

2020 ◽  
pp. 15-23
Author(s):  
G. V. Nekludova ◽  
A. V. Chernyak
Keyword(s):  
Carbon Monoxide ◽  
Working Group ◽  
American Thoracic Society ◽  
Diagnostic Systems ◽  
European Respiratory Society ◽  
Diffusion Capacity ◽  
Single Breath ◽  
Joint Working Group ◽  
Single Breath Method

The article provides an overview of the technical capabilities and updated standards for the study of diffusion capacity of the lungs using diagnostic systems using rapidly responding gas analyzers (RGA analyzers — rapidly responding gas analyzers) of carbon monoxide and indicator gas, presented by a joint working group of the European Respiratory Society (ERC) and the American Thoracic Society (ATS).

The Relationship Between Single-Breath Diffusion Capacity of the Lung for Nitric Oxide and Carbon Monoxide During Various Exercise Intensities

CHEST Journal ◽  
2004 ◽  
Vol 125 (3) ◽  
pp. 1019-1027 ◽  
Author(s):  
Gerald S. Zavorsky ◽  
Karine Badra Quiron ◽  
Philip S. Massarelli ◽  
Larry C. Lands
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Diffusion Capacity ◽  
Single Breath ◽  
The Relationship

The effect of conductive ventilation heterogeneity on diffusing capacity measurement

2008 ◽  
Vol 104 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Sylvia Verbanck ◽  
Daniel Schuermans ◽  
Sophie Van Malderen ◽  
Walter Vincken ◽  
Bruce Thompson
Keyword(s):  
Carbon Monoxide ◽  
Vital Capacity ◽  
Experimental Situation ◽  
Normal Subjects ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
Alveolar Volume ◽  
Estimation Errors ◽  
Single Breath ◽  
Ventilation Heterogeneity

It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and related the resulting changes in conductive ventilation heterogeneity (derived from the multiple-breath washout test) to corresponding changes in diffusing capacity, alveolar volume, and inspired vital capacity (derived from the single-breath DlCO method). Average conductive ventilation heterogeneity doubled ( P < 0.001), whereas DlCO decreased by 6% ( P < 0.001), with no correlation between individual data ( P > 0.1). Average inspired vital capacity and alveolar volume both decreased significantly by, respectively, 6 and 3%, and the individual changes in alveolar volume and in conductive ventilation heterogeneity were correlated ( r = −0.46; P = 0.006). These findings can be brought in agreement with recent modeling work, where specific ventilation heterogeneity resulting from different distributions of either inspired volume or end-expiratory lung volume have been shown to affect DlCO estimation errors in opposite ways. Even in the presence of flow asynchrony, these errors appear to largely cancel out in our experimental situation of histamine-induced conductive ventilation heterogeneity. Finally, we also predicted which alternative combination of specific ventilation heterogeneity and flow asynchrony could affect DlCO estimate in a more substantial fashion in diseased lungs, irrespective of any diffusion-dependent effects.

scholarly journals Relationship Between Exhaled Na+ and the Diffusion Capacity of the Lungs for Carbon Monoxide (DLCO) and Alveolar‐Capillary Membrane Conductance in Healthy Humans

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Courtney M. Wheatley ◽  
Nicholas A. Cassuto ◽  
William T. Foxx‐Lupo ◽  
Eric C. Wong ◽  
Nicholas A. Delamere ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Membrane Conductance ◽  
Diffusion Capacity ◽  
Healthy Humans ◽  
Capillary Membrane ◽  
Alveolar Capillary

Single Breath Carbon Monoxide Diffusing Capacity

1988 ◽  
Vol 137 (5) ◽  
pp. 1244-1244
Author(s):  
Edith Rosenberg ◽  
Margaret R. Becklake
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Single Breath
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