Recent Advances in our Understanding of Hepatitis B Infections

2015 ◽  
pp. 8-16
Author(s):  
A. M. Prince ◽  
W. Szmuness ◽  
B. Brotman ◽  
H. Ikram
Keyword(s):  
Hepatitis B ◽  
Recent Advances

Recent Advances in our Understanding of Hepatitis B Infections

Vox Sanguinis ◽  
1973 ◽  
Vol 24 ◽  
pp. 8-16 ◽  
Author(s):  
A. M. Prince ◽  
W. Szmuness ◽  
B. Brotman ◽  
H. Ikram
Keyword(s):  
Hepatitis B ◽  
Recent Advances

Recent advances in the molecular biology of hepatitis B virus

1996 ◽  
Vol 10 (2) ◽  
pp. 207-225 ◽  
Author(s):  
Pier Paolo Scaglioni ◽  
Margherita Melegari ◽  
Jack R. Wands
Keyword(s):  
Hepatitis B Virus ◽  
Molecular Biology ◽  
Hepatitis B ◽  
Recent Advances ◽  
B Virus

scholarly journals Recent advances in understanding and diagnosing hepatitis B virus infection

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2243 ◽  
Author(s):  
Slim Fourati ◽  
Jean-Michel Pawlotsky
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Modulation ◽  
Hepatitis B Surface Antigen ◽  
Sodium Taurocholate ◽  
Hbv Infection ◽  
New Drugs ◽  
Recent Advances ◽  
Hbsag Detection ◽  
B Virus

Hepatitis B virus (HBV) infects approximately 240 million individuals worldwide. Recent advances in the virology, immunopathogenesis, and diagnosis of HBV infection are summarized in this review article. The identification of a hepatocyte-specific cellular receptor for HBV, the sodium taurocholate co-transporting polypeptide (NTCP), made it possible to develop reliable cell culture systems and better understand the early steps of the viral lifecycle. Viral and host factors involved in covalently closed circular DNA synthesis, stability, and transcriptional regulation have also been identified and provide potential targets for new drugs. Based on recent evidence showing trained immunity in immune-tolerant patients, the immune tolerance and immune clearance phases have been renamed the non-inflammatory and inflammatory phases, respectively. New diagnostic and monitoring tools are now available, including rapid diagnostic tests for hepatitis B surface antigen (HBsAg) detection, HBsAg quantification assays, anti-HBc antibody quantification assays, an HBV core-related antigen (HBcrAg) quantification test, new HBV DNA detection and quantification assays, and an HBV RNA quantification test. Their clinical utility is under study. Finally, new antiviral and immune modulation approaches are in the preclinical or early clinical developmental stages, with the goal to achieve functional cure or ideally (if possible) eradication of HBV infection.

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