Quantitation of Hepatic Bilirubin Conjugation

2015 ◽  
pp. 203-209
Author(s):  
J. Fevery ◽  
J. De Groote ◽  
K. P. M. Heirwegh
Keyword(s):  
Bilirubin Conjugation

Temporary amelioration of bilirubin conjugation defect in Gunn rats by transplanting conditionally immortalized hepatocytes

2002 ◽  
Vol 17 (6) ◽  
pp. 690-696 ◽  
Author(s):  
BYUNG-HO KIM ◽  
YO SEB HAN ◽  
SEOK HO DONG ◽  
HYO JONG KIM ◽  
YOUNG WOON CHANG ◽  
...  
Keyword(s):  
Gunn Rats ◽  
Immortalized Hepatocytes ◽  
Bilirubin Conjugation

scholarly journals 226 DEVELOPMENT OF BILIRUBIN CONJUGATION IN HUMAN NEW-BORNS

1981 ◽  
Vol 15 ◽  
pp. 477-477
Author(s):  
Norbert Blanckaert ◽  
Philip Rosenthal ◽  
Michael M Thaler
Keyword(s):  
Bilirubin Conjugation

Sodium glucuronate and glucuronolactone in bilirubin conjugation and formation of borneol glucuronide

1959 ◽  
Vol 197 (6) ◽  
pp. 1322-1326 ◽  
Author(s):  
Shirley G. Driscoll ◽  
David Y. Y. Hsia ◽  
David A. Dennen ◽  
Robert M. Dowben
Keyword(s):  
Intravenous Infusion ◽  
Intact Animal ◽  
Indirect Pathway ◽  
Direct Incorporation ◽  
Bilirubin Conjugation

Sodium glucuronate, glucuronolactone or glucose labeled uniformly with radiocarbon was administered intravenously to dogs together with an intravenous infusion of bilirubin. When sodium glucuronate was injected, the bile recovered in the succeeding 3 hours contained 4.16 x 10–6 and 8.33 x 10–7 of the labeled material injected per milligram bilirubin. Recoveries after injection of labeled glucuronolactone were 4.98 x 10–5 and 7.94 x 10–5 of the administered label per milligram bilirubin excreted, and when labeled glucose was given, the fractions recovered were 3.39 x 10–4 and 4.91 x 10–4/mg bilirubin. Radioautograms of paper chromatograms of bile showed radioactivity at the spots corresponding to bilirubin glucuronide when glucose was the labeled substrate. An average of 0.89% glucuronolactone-1-C14 given together with borneol to rats appeared in the borneol glucuronide isolated from urine. When glucuronolactone-6-C14 was used as substrate, the incorporation into borneol glucuronide was not significant. These data are interpreted to indicate the incorporation of a very small but definite fraction of administered glucuronolactone into glucuronide conjugates via an indirect pathway; significant direct incorporation does not occur in the intact animal. However, glucose is a more effective precursor of bilirubin glucuronide than glucuronolactone.

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