Experimental Studies of Galactose Elimination Capacity as a Quantitative Measure of Hepatocellular Function

2015 ◽  
pp. 156-163
Author(s):  
S. Keiding ◽  
F. V. Hansen ◽  
K. T�nnesen ◽  
N. Tygstrup
Keyword(s):  
Experimental Studies ◽  
Quantitative Measure ◽  
Elimination Capacity ◽  
Galactose Elimination Capacity ◽  
Galactose Elimination

Hepatic, renal, and total body galactose elimination in the pig

1993 ◽  
Vol 265 (1) ◽  
pp. G9-G14 ◽  
Author(s):  
K. Winkler ◽  
J. H. Henriksen ◽  
N. Tygstrup
Keyword(s):  
Quantitative Measure ◽  
The Body ◽  
Elimination Capacity ◽  
Whole Body ◽  
Renal Elimination ◽  
Maximal Velocity ◽  
Blood Concentrations ◽  
Galactose Elimination Capacity ◽  
Total Body ◽  
Galactose Elimination

Galactose elimination capacity is used as a quantitative measure of liver function on the assumption that galactose elimination outside the liver is negligible or easily corrected for. The relationship between hepatic and extrahepatic removal of galactose was studied in anesthetized pigs during quasi-steady-state conditions by continuous infusion of galactose. The hepatic removal approximated a constant [maximal velocity = 585 +/- 41 mumol/min, Michaelis constant (Km) = 0.24 +/- 0.07 mmol/l, mean +/- SE, n = 20]. The renal removal was less than the amount filtered, showing maximal tubular reabsorption (Tm 178 +/- 3.0 mumol/min, Km 3.8 +/- 0.9 mmol/l, n = 20). Metabolic conversion of galactose in the kidney was not demonstrable. At all concentrations studied (0.4-5.8 mmol/l), total galactose elimination from the body exceeded the sum of hepatic and renal elimination by approximately 100 mumol/min, independent of the concentration. At blood concentrations usually used for clinical estimation of the galactose elimination capacity (approximately 4 mmol/l), hepatic removal in the pig accounted for 55% and renal removal for 30% of total removal; 15% of removal occurred in other organs. We conclude that estimation of the hepatic galactose elimination capacity from whole body elimination curves requires correction for renal removal of galactose.

Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis

1991 ◽  
Vol 36 (9) ◽  
pp. 1197-1203 ◽  
Author(s):  
Carlo Merkel ◽  
Angelo Gatta ◽  
Marco Zoli ◽  
Massimo Bolognesi ◽  
Paolo Angeli ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Breath Test ◽  
Elimination Capacity ◽  
Aminopyrine Breath Test ◽  
Galactose Elimination Capacity ◽  
Icg Clearance ◽  
Galactose Elimination

EVALUATION OF AMMONIA AND LIDOCAINE CLEARANCE, AND GALACTOSE ELIMINATION CAPACITY OF XENOPERFUSED PIG LIVERS USING A PHARMACOKINETIC ANALYSIS1

1999 ◽  
Vol 68 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Takehiko Uesugi ◽  
Iwao Ikai ◽  
Toshikazu Yagi ◽  
Seiji Satoh ◽  
Akiyoshi Kanazawa ◽  
...  
Keyword(s):  
Elimination Capacity ◽  
Galactose Elimination Capacity ◽  
Galactose Elimination
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