Imipramine and Viloxazine Plasma Levels and their Relevance to Antidepressant Response

2015 ◽  
pp. 112-118
Author(s):  
M. M. Amin ◽  
R. Khalid ◽  
P. Khan
Keyword(s):  
Plasma Levels ◽  
Antidepressant Response

Plasma levels of bupropion (BUP), major metabolites and antidepressant response in juveniles

2005 ◽  
Vol 77 (2) ◽  
pp. P94-P94
Author(s):  
J PEREL ◽  
W DAVISS ◽  
G RUDOLPH ◽  
D AXELSON ◽  
S NUSS ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Antidepressant Response

Protriptyline plasma levels and antidepressant response

1977 ◽  
Vol 22 (3) ◽  
pp. 269-273 ◽  
Author(s):  
John T. Biggs ◽  
Vincent E. Ziegler
Keyword(s):  
Plasma Levels ◽  
Antidepressant Response

Plasma levels of interleukin-6 and antidepressant response to Paroxetine in Chinese depressive patients

2021 ◽  
Vol 297 ◽  
pp. 113723
Author(s):  
Zaiquan Dong ◽  
Weihong Kuang ◽  
Xiaoling Shen ◽  
Liantian Tian
Keyword(s):  
Interleukin 6 ◽  
Plasma Levels ◽  
Antidepressant Response ◽  
Depressive Patients

Acute Antidepressant Response and Plasma Levels of Bupropion and Metabolites in a Pediatric-Aged Sample

2006 ◽  
Vol 28 (2) ◽  
pp. 190-198 ◽  
Author(s):  
W. Burleson Daviss ◽  
James M. Perel ◽  
David A. Brent ◽  
David A. Axelson ◽  
George R. Rudolph ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Aged Sample ◽  
Antidepressant Response

Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine

2010 ◽  
Vol 25 (8) ◽  
pp. 476-478 ◽  
Author(s):  
F. Benedetti ◽  
S. Dallaspezia ◽  
C. Colombo ◽  
C. Lorenzi ◽  
A. Pirovano ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Plasma Levels ◽  
Repeated Measures ◽  
Individual Response ◽  
Antidepressant Response ◽  
Major Depressive ◽  
Factors Affecting ◽  
Antidepressant Efficacy ◽  
Drug Plasma Levels ◽  
The Individual

AbstractRationaleThe catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity. Recent clinical studies found a significant effect of rs4680 on antidepressant response to fluoxetine and paroxetine, but several other studies were negative. No study considered drug plasma levels as possible nuisance covariate.ObjectivesWe studied the effect of rs4680 on response to fluvoxamine antidepressant monotherapy.Patients and methodsForty-one consecutively admitted inpatients affected by a major depressive episode in course of major depressive disorder were administered fluvoxamine for 6 weeks. Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed with repeated measures ANOVA in the context of General Linear Model, with rs4680 and fluvoxamine plasma levels as factors.Resultsrs4680 significantly interacted with time in affecting antidepressant response to fluvoxamine, with outcome being inversely proportional to the enzyme activity: better effects in Met-carriers, worse effects in Val/Val homozygotes. The effect became significant at the fourth week of treatment, and influence final response rates. Fluvoxamine plasma levels had marginal effects on outcome.ConclusionsThis is the first study that reports a positive effect of rs4680 on response to fluvoxamine, and the third independent report of its influence on response to selective 5-HT reuptake inhibitors (SSRIs). Our findings support the hypothesis that factors affecting catecholaminergic neurotransmission might contribute to shape the individual response to antidepressants irrespective of their primary molecular target.

Escitalopram plasma levels and antidepressant response

2017 ◽  
Vol 27 (9) ◽  
pp. 940-944 ◽  
Author(s):  
Vincenzo Florio ◽  
Stefano Porcelli ◽  
Alois Saria ◽  
Alessandro Serretti ◽  
Andreas Conca
Keyword(s):  
Plasma Levels ◽  
Antidepressant Response

Milnacipran plasma levels and antidepressant response in Japanese major depressive patients

2003 ◽  
Vol 18 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Hisashi Higuchi ◽  
Keizo Yoshida ◽  
Hitoshi Takahashi ◽  
Shingo Naito ◽  
Mitsuhiro Kamata ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Antidepressant Response ◽  
Major Depressive ◽  
Depressive Patients

Urokinase type plasminogen activator and inhibitor type-1 plasma levels in colorectal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A599-A600 ◽  
Author(s):  
L HERSZENYI ◽  
F FARINATI ◽  
G ISTVAN ◽  
M PAOLI ◽  
G ROVERONI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Plasminogen Activator ◽  
Plasma Levels ◽  
Type Plasminogen Activator ◽  
Urokinase Type Plasminogen Activator ◽  
Inhibitor Type
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