Putative Neurotrophic Factors in Brain Tissue - Novel Neuromodulators?

2015 ◽  
pp. 68-84
Author(s):  
M. P. Rathbone ◽  
R. L. Carlone ◽  
R. H. C. Van der Jagt ◽  
M. Ganagarajah
Keyword(s):  
Brain Tissue ◽  
Neurotrophic Factors

Analysis of brain biocompatibility of drug-releasing biodegradable microspheres by scanning and transmission electron microscopy

2001 ◽  
Vol 95 (3) ◽  
pp. 489-494 ◽  
Author(s):  
Joëlle Veziers ◽  
Maurice Lesourd ◽  
Christophe Jollivet ◽  
Claudia Montero-Menei ◽  
Jean-Pierre Benoit ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Brain Tissue ◽  
Neurotrophic Factors ◽  
Rat Striatum ◽  
Inert Material ◽  
Biodegradable Microspheres ◽  
Content Type ◽  
Transmission Electron ◽  
Fine Print

Object. Stereotactically guided implantation of biodegradable microspheres is a promising strategy for delivery of neurotrophic factors in a precise and spatially defined brain area. The goal in this study was to show the biocompatibility of poly(D,L,lactide-co-glycolide) microspheres with brain tissue at the ultrastructural level and to analyze the three-dimensional (3D) ultrastructure after intrastriatal implantation of these microparticles. Methods. Scanning and transmission electron microscopy were used to study the microspheres and their environment after implantation in an inert material (gelatin) and in the rat striatum. Observations were made at different time periods, ranging from 24 hours to 2 months postimplantation. Conclusions. The progressive degradation of the microspheres, with vacuolization, deformation, and shrinkage, was well visualized. This degradation was identical in microspheres implanted in the inert material and in the rat brain tissue, independent of the presence of macrophages. The studies preformed in the striatum permitted the authors to demonstrate the structural integrity of axons in contact with microspheres, confirming the biocompatibility of the polymer. Furthermore, scanning electron microscopy showed the preservation of the 3D ultrastructure of the striatum around the microparticles. These microparticles, which can be stereotactically implanted in functional areas of the brain and can release neurotrophic factors, could represent, for some indications, an alternative to gene therapy.

EFFECTS OF REPEATEDLY HEADING A SOCCER BALL ON SERUM LEVELS OF TWO NEUROTROPHIC FACTORS OF BRAIN TISSUE, BDNF AND NGF, IN PROFESSIONAL SOCCER PLAYERS

2011 ◽  
Vol 28 (3) ◽  
pp. 177-181 ◽  
Author(s):  
B. Bamac ◽  
G.S. Tamer ◽  
T. Colak ◽  
E. Colak ◽  
E. Seyrek ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Neurotrophic Factors ◽  
Serum Levels ◽  
Soccer Players ◽  
Soccer Ball ◽  
Professional Soccer

Modulation of rat visceral pain by brain-derived neurotrophic factors (BDNF)

2010 ◽  
Vol 34 (8) ◽  
pp. S22-S22
Author(s):  
Rong Wei ◽  
Ying Gao ◽  
Xiaoxue Ding ◽  
Ziqi Yue ◽  
Sha Wu ◽  
...  
Keyword(s):  
Neurotrophic Factors ◽  
Visceral Pain

Effects of therapeutic and toxic phenobarbital doses on brain tissue caspase 3-activity in the neonatal rat

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
R Husain ◽  
HS Fink ◽  
K Lang ◽  
B Merkle ◽  
R Bauer ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Caspase 3 ◽  
Neonatal Rat

Effects of Hormone Replacement Therapy on Plasma and Tissue Fibrinolytic Activity in a Rat Model of Surgically Induced Menopause

2014 ◽  
Vol 37 (2) ◽  
pp. 85 ◽  
Author(s):  
Ata Topcuoglu ◽  
Mustafa Albayrak ◽  
Hayriye Erman ◽  
Huriye Balci ◽  
Mesut Karakus ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Oral Administration ◽  
Replacement Therapy ◽  
Plasminogen Activator ◽  
Brain Tissue ◽  
Fibrinolytic Activity ◽  
Hormone Replacement ◽  
17Β Estradiol ◽  
Surgically Induced ◽  
Pai 1

Purpose: The purpose of this study was to analyze the effects of estrogen deficiency and hormone replacement therapy (HRT) on fibrinolytic activity in a rat mode of surgically-induced menopause. Methods: Twelve-week-old, sexually mature female Sprague-Dawley rats, each weighing 200–250 g, were randomly divided into four groups: (1) sham-operated group, (2) ovariectomy group, (3) ovariectomy group followed by oral administration of daily 17β-estradiol (0.02 mg/kg/day) (E2) + norethisterone acetate (0.01 mg/kg/day), and (4) ovariectomy group followed by oral administration of daily 17β-estradiol (0.01 mg/kg/day) + drospirenone (0.02 mg/kg/day). Tissue plasminogen activator (tPA) antigen, plasminogen activator inhibitor-1 (PAI-1) antigen, and PAI-1/tPA levels were measured as markers of fibrinolysis in plasma and liver and brain tissue. Results: Compared with sham-operated rats, ovariectomized rats showed higher levels of fibrinolytic activity; however, the increased fibrinolytic activity in plasma and liver tissue was significantly reduced by HRT regimens. No change was observed in the levels of fibrinolytic activity in brain tissue. Conclusions: HRT showed beneficial effects by decreasing fibrinolytic activity related to surgically-induced menopause. Short-term HRT treatment was associated with a shift in the procoagulant-anticoagulant balance toward a procoagulant state.

Improvement of somatopsychic and cognitive abilities in a post-stroke patient treated with neurotrophic factors

Psihiatru ro ◽  
2020 ◽  
Vol 4 (63) ◽  
pp. 30
Author(s):  
Gabriela Marian ◽  
Brânduşa Ecaterina Focşeneanu ◽  
George Stercu ◽  
Andrei-Cristian Bondar ◽  
Claudiu Pavel ◽  
...  
Keyword(s):  
Stroke Patient ◽  
Neurotrophic Factors ◽  
Cognitive Abilities ◽  
Post Stroke
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