Oncogenic and Nononcogenic Mutants of Adenovirus 12: Induction of Chromosome Aberrations and Cell Divisions1

2015 ◽  
pp. 260-272 ◽  
Author(s):  
H. F. Stich
Keyword(s):  
Chromosome Aberrations

Bestimmung der DNA-Schädigung in vitro

2010 ◽  
Vol 49 (S 01) ◽  
pp. S64-S68
Author(s):  
E. Dikomey
Keyword(s):  
Dna Damage ◽  
Cell Lines ◽  
Chromosome Aberrations ◽  
Genetic Factors ◽  
Double Strand Breaks ◽  
Strand Breaks ◽  
Cell Inactivation ◽  
Repair Mechanisms ◽  
Break Repair

SummaryIonising irradiation acts primarily via induction of DNA damage, among which doublestrand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of doublestrand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about doublestrand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.

scholarly journals DNA-Replikationsstress, Mitose und genomische Instabilität

BIOspektrum ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 10-13
Author(s):  
Alicia Konrath ◽  
Ann-Kathrin Schmidt ◽  
Holger Bastians
Keyword(s):  
Dna Replication ◽  
Tumor Progression ◽  
Chromosome Aberrations ◽  
Chromosomal Instability ◽  
Chromosome Instability ◽  
Replication Stress ◽  
Functional Link ◽  
Structural Chromosome ◽  
Genomische Instabilität

AbstractChromosomal instability (CIN) is a hallmark of cancer and contributes to tumorigenesis and tumor progression. While structural CIN (S-CIN) leads to structural chromosome aberrations, whole chromosome instability (W-CIN) is defined by perpetual gains or losses of chromosomes during mitosis causing aneuploidy. Mitotic defects, but also abnormal DNA replication (replication stress) can lead to W-CIN. However, the functional link between replication stress, mitosis and aneuploidy is little understood.

Numerical Chromosome Aberrations in Fibrothecoma

1992 ◽  
Vol 78 (2) ◽  
pp. 140-142 ◽  
Author(s):  
Paola Dal Cin ◽  
Philippe Moerman ◽  
Ivo De Wever ◽  
Herman Van Den Berghe
Keyword(s):  
Chromosome Aberrations ◽  
Genital Tract ◽  
Cytogenetic Analysis ◽  
Female Genital Tract ◽  
Chromosome 12 ◽  
Mesenchymal Tumors ◽  
Extra Copy ◽  
Embryonic Origin ◽  
Numerical Chromosome ◽  
Female Genital

Cytogenetic analysis on a 7-day-old culture of a fibrothecoma showed only numerical chromosome abnormalities: 57, XX, +4, +5, +6, +10, + 12, +12, +14, +17, +18, +19, +20. The finding of an extra copy of chromosome 12 in mesenchymal tumors, mostly benign and originating from the female genital tract, may possibly point towards their common embryonic origin.

Chromosome Aberrations and the Cell Cycle

1968 ◽  
Vol 33 (3) ◽  
pp. 609 ◽  
Author(s):  
Sheldon Wolff
Keyword(s):  
Cell Cycle ◽  
Chromosome Aberrations
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