On the Central Mechanism of Latent Nystagmus

2015 ◽  
pp. 204-204
Author(s):  
A. G. M. van Vliet
Keyword(s):  
Central Mechanism ◽  
Latent Nystagmus

Prevention and Healing of Calcium Signaling Mediated Neuronal Damage on successive Administration of Flavonoid Enriched Pterocarpus Marsupium Roxb in Peripheral Neuropathy Model

2020 ◽  
Vol 16 (9) ◽  
pp. 1346-1355
Author(s):  
Neethi Shaju ◽  
Mrinmoy Gautam ◽  
Abdul Khayum ◽  
Gunasekaran Venkatesh
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Sciatic Nerve ◽  
Motor Neurons ◽  
Neuronal Damage ◽  
Interleukin 10 ◽  
Central Mechanism ◽  
Behavioral Models ◽  
Cell Hyperplasia ◽  
Pterocarpus Marsupium

Background: Modern research on peripheral neuropathy circumstance utter that treatments with Vincristine (VCR) disturb the microtubular cells in sensory and motor neurons due to calcium over- load in sciatic nerve, unfortunately, VCR triggering the release of Tumor necrosis factor-α (TNFα) in central neurons causes excitotoxicity as well. Although ethnomedical information specifies that Pterocarpus marsupium Roxb (PM) is widely used for various nervous disorders, not yet justified on VCR induced peripheral neuropathy and in relation to central mechanism. Objective: This study is aimed to explore the possible central and peripheral mechanism of flavonoid enriched PM in VCR induced neuropathy model. Methods: Neuropathic pain was induced in female Wistar rats by VCR (75μg/ kg/day, i.p) for 10 days. Nociceptive thresholds were assessed by subjecting them to behavioral and biochemical estimation, proinflammatory cytokines along with morphological evaluation. Results: PM significantly increased the nociceptive threshold evident from various behavioral models in comparison to VCR group. More importantly, PM significantly reversed the VCR induced calcium elevation, glutamate and aspartate release in the brain. Discussion: It was also observed that the raised TNF-α, Interleukin-1β were controlled and interleukin- 10 was elevated in sciatic nerve after PM treatment. Evident from histology, PM markedly reversed the VCR induced axonal degeneration, Schwann cell hyperplasia, and myelin fibrosis. Conclusion: Flavonoid enriched PM both 100 & 200mg/kg post and co-administration exerted a preventive and curative effect in VCR induced neuropathic pain by controlling calcium-mediated excitotoxicity through peripheral and central mechanism.

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

Circulation ◽  
1997 ◽  
Vol 96 (12) ◽  
pp. 4357-4363 ◽  
Author(s):  
Naoki Katsumata ◽  
Hiroaki Shimokawa ◽  
Minoru Seto ◽  
Toshiyuki Kozai ◽  
Tohru Yamawaki ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Light Chain ◽  
Myosin Light Chain ◽  
Coronary Artery Spasm ◽  
Central Mechanism ◽  
Interleukin 1Β ◽  
Swine Model

THE CENTRAL MECHANISM OF THE EMOTIONS

1951 ◽  
Vol 108 (6) ◽  
pp. 426-432 ◽  
Author(s):  
E. A. SPIEGEL ◽  
H. T. WYCIS ◽  
H. FREED ◽  
C. ORCHINIK
Keyword(s):  
Central Mechanism

scholarly journals RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability

2003 ◽  
Vol 162 (7) ◽  
pp. 1267-1279 ◽  
Author(s):  
Jorge Santos Da Silva ◽  
Miguel Medina ◽  
Cecilia Zuliani ◽  
Alessia Di Nardo ◽  
Walter Witke ◽  
...  
Keyword(s):  
Neuronal Differentiation ◽  
Hippocampal Neurons ◽  
Morphological Changes ◽  
Decisive Role ◽  
Central Mechanism ◽  
Actin Binding ◽  
Actin Binding Protein ◽  
Rhoa Activity ◽  
Neuronal Soma ◽  
Cultured Hippocampal Neurons

Neuritogenesis, the first step of neuronal differentiation, takes place as nascent neurites bud from the immediate postmitotic neuronal soma. Little is known about the mechanisms underlying the dramatic morphological changes that characterize this event. Here, we show that RhoA activity plays a decisive role during neuritogenesis of cultured hippocampal neurons by recruiting and activating its specific kinase ROCK, which, in turn, complexes with profilin IIa. We establish that this previously uncharacterized brain-specific actin-binding protein controls neurite sprouting by modifying actin stability, a function regulated by ROCK-mediated phosphorylation. Furthermore, we determine that this novel cascade is switched on or off by physiological stimuli. We propose that RhoA/ROCK/PIIa-mediated regulation of actin stability, shown to be essential for neuritogenesis, may constitute a central mechanism throughout neuronal differentiation.

Clinical value of melatonin in the development of central mechanism disorders of reproductive function regulation

1997 ◽  
Vol 78 (6) ◽  
pp. 430-433
Author(s):  
F. A. Fattakhova ◽  
Z. Sh. Gilyazutdinova ◽  
M. K. Mikhailov
Keyword(s):  
Thyroid Gland ◽  
Pineal Gland ◽  
Reproductive Function ◽  
Physiological Process ◽  
Central Mechanism ◽  
Clinical Value ◽  
Calcification Process

The excretion of melatonin in central mechanism disorders of reproductive function regulation is studied. It is stated that thyroid gland calcification is a physiological process and calcification process inhibition is a manifestation of hormonal homeostasis disorder in patients with neuroendocrinic pathology. The treatment of patients with sterility in the galactorrhea-amenorrhea syndrome and scleropolycystosis of ovaries of central genesis is to be performed differentially taking into account pineal gland state.

scholarly journals Latent Nystagmus

2004 ◽  
Vol 122 (2) ◽  
pp. 202 ◽  
Author(s):  
Michael C. Brodsky
Keyword(s):  
Latent Nystagmus
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