L-Dopa, Parkinson�s Disease and Pupillary Reaction to Light

Author(s):  
W. Knopp ◽  
M. Rotenberg ◽  
R. Boye
Keyword(s):  

Background: The pupillary reaction is controlled by the two main branches of the autonomic nervous system, namely the parasympathetic and sympathetic nervous systems. New discoveries in pupil research has identified that intrinsically photosensitive retinal ganglion cells have an impact on pupillary constriction, particularly sustained pupillary constriction. In the current paper, an objective measurement of sustained pupillary constriction versus the inability to maintain sustained pupillary constriction are observed. The variability in the sustained pupillary constriction, i.e. Alpha Omega pupil, can be objectively identified with the use of modern technology. Case Examples: Two female subjects were adapted to dim illumination, and then two objective pupil measurements of the right eye using Reflex – PLR Analyzer by BrightLamp© (Indianapolis, IN, USA) with sustained illumination were obtained. Subject 1, a 25 year-old-female, demonstrated normal ability of the pupil to constrict and sustain constriction for 10 seconds. She was used as a control for subject 2. Subject 2, a 27 year-old-female, demonstrated the inability to sustain pupillary constriction. She reported being under great psychological stress. Her pupil began to re-dilate between 2 and 3 seconds after the initial constriction. Conclusion: Objective pupillometry can be used to assist in many diagnoses and provides the clinician invaluable information on the state of the individual, and qualifications of sustained pupillary constriction can now be assessed in an objective manner.


2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Ahmed Al-Imam

An eighteen-year-old female patient of the Caucasian ethnicity from Australasia presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when she is outdoors due to oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD, NBOMe, psilocybin, and DMT. The condition affects both eyes to the same extent. Thorough medical, neurological, and radiological examinations, including an EEG and an MRI of the head and neck region, were completely normal. All these tests failed to detect any pathophysiological or anatomical abnormalities. The patient is a known case of chronic endogenous depression in association with attention deficit hyperactivity disorder, for which she is taking citalopram and Ritalin, respectively. There was neither a family history nor a similar congenital condition in her family.


2010 ◽  
Vol 07 (01) ◽  
pp. 213-222 ◽  
Author(s):  
MIOMIR VUKOBRATOVIĆ ◽  
MILOŠ JOVANOVIĆ

The article presents the facts about the pioneering research results of Professor Nikolai Bernstein in the area of man's voluntary movements. Relevant data are given concerning the priority of introducing the notion of feedback in the process of active voluntary human movements, twelve years before the known Wiener's publication. Bernstein demonstrated how the problems of general physiology can be explored in terms of the structural analysis of movements. He dealt with the most important aspects of the vital activity of higher organisms, and how this has been accorded the place in physiology and, when it developed, promised to be of the greatest value in cybernetics and in the exact mathematical formulation of a physiological theory of motor behavior. In his research, Bernstein modeled the function of the central nervous system and offered the cyberneticists a system for the development of analogs for experimental model-making that was not only incomparably richer than examples of internal stabilizing processes (blood-pressure, temperature and sugar-level regulating systems, for example), and also more complex than the systems of dynamic regulation that have already been studied in some depth, such as the mechanisms of ocular accommodation, or of the pupillary reaction.


1925 ◽  
Vol 71 (2) ◽  
pp. 274-276
Author(s):  
Theodore Koppanyi ◽  
Nelles B. Laughton

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