Neuronal and Extraneuronal Uptake of Adrenergic Transmitter in the Blood Vessel1

2015 ◽  
pp. 22-34 ◽  
Author(s):  
O. A. Nedergaard ◽  
J. A. Bevan
Keyword(s):  
Extraneuronal Uptake

Neuronal and Extraneuronal Uptake of 3H-Norepinephrine in the Heart of the Active Bat: An Electron Microscopic Radioautographic Study

1973 ◽  
Vol 31 ◽  
pp. 522-523
Author(s):  
Martin Hagopian ◽  
Michael D. Gershon ◽  
Eladio A. Nunez
Keyword(s):  
Smooth Muscle ◽  
Monoamine Oxidase ◽  
Vascular Smooth Muscle ◽  
Cardiac Muscle ◽  
Maximum Rate ◽  
External Medium ◽  
Extraneuronal Uptake ◽  
Electron Microscopic ◽  
Cardiac Tissues ◽  
High Affinity

The ability of cardiac tissues to take up norepinephrine from an external medium is well known. Two mechanisms, called Uptake and Uptake respectively by Iversen have been differentiated. Uptake is a high affinity system associated with adrenergic neuronal elements. Uptake is a low affinity system, with a higher maximum rate than that of Uptake. Uptake has been associated with extraneuronal tissues such as cardiac muscle, fibroblasts or vascular smooth muscle. At low perfusion concentrations of norepinephrine most of the amine taken up by Uptake is metabolized. In order to study the localization of sites of norepinephrine storage following its uptake in the active bat heart, tritiated norepinephrine (2.5 mCi; 0.064 mg) was given intravenously to 2 bats. Monoamine oxidase had been inhibited with pheniprazine (10 mg/kg) one hour previously to decrease metabolism of norepinephrine.

Effects of corticoadrenal extract on the neuronal and extraneuronal uptake of noradrenaline in the isolated rabbit heart

1985 ◽  
Vol 72 (2) ◽  
pp. 94-95
Author(s):  
Pham Huu Chanh ◽  
R. Kaiser ◽  
R. Chahine ◽  
K. Abou Khalil ◽  
M. Abou-Assaly ◽  
...  
Keyword(s):  
Rabbit Heart ◽  
Extraneuronal Uptake ◽  
Isolated Rabbit Heart ◽  
Uptake Of Noradrenaline

EXTRANEURONAL UPTAKE AND METABOLISM OF CATECHOLAMINES IN ISOLATED PERFUSED HEARTS

1976 ◽  
pp. 117-130 ◽  
Author(s):  
K.-H. Graefe ◽  
H. Bönisch ◽  
R. Fiebig ◽  
U. Trendelenburg
Keyword(s):  
Extraneuronal Uptake ◽  
Perfused Hearts ◽  
Uptake And Metabolism
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