Analysis of Multiple Site Phosphorylation of H1 Histone

2015 ◽  
pp. 70-82 ◽  
Author(s):  
T. A. Langan ◽  
C. E. Zeilig ◽  
B. Leichtling
Keyword(s):  
Multiple Site ◽  
H1 Histone

Risk of osteonecrosis in systemic lupus erythematosus: An 11-year Chinese single-center cohort study

Lupus ◽  
2021 ◽  
pp. 096120332110211
Author(s):  
Yin Long ◽  
Shangzhu Zhang ◽  
Jiuliang Zhao ◽  
Hanxiao You ◽  
Li Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Risk Factor ◽  
Femoral Head ◽  
Lupus Erythematosus ◽  
Femoral Head Necrosis ◽  
Joint Involvement ◽  
Multiple Site ◽  
Systemic Lupus ◽  
Cns Involvement

Objective Osteonecrosis (ON), which can lead to physical disability, is a common complication of systemic lupus erythematosus (SLE). The purpose of this study was to determine the prevalence of ON and identify possible risk factors in Chinese SLE patients. Methods SLE patients who fulfilled the 1997 American College of Rheumatology SLE classification criteria were recruited from the Peking Union Medical College Hospital. The chi-square test (χ 2 test) and multivariate regression analyses were used to evaluate risk factors. The Cox proportional-hazards model was used to construct the survival curves and estimate the simultaneous effects of prognostic factors on survival. Results We consecutively enrolled 1,158 patients, of which 88 patients (7.6%) developed ON. Among ON patients, 57.1% of patients had isolated femoral head necrosis and 42.9% had multiple joint involvement. The mean age of ON patients (24.62 ± 8.89 years) was significantly younger than SLE patients without ON (27.23 ± 10.16 years, p = 0.09). The ON group presented with a much longer disease course (10.68 ± 5.97 years, p < 0.001) and increased incidence of arthritis, kidney, and central nervous system (CNS) involvement (65.9% [ p < 0.05], 57.6% [ p < 0.05], and 16.5% [ p < 0.05], respectively, in the ON group). ON patients were more likely to be treated with glucocorticoid (GC) and to receive a high dose of prednisolone at the initial stage of SLE ( p < 0.05). The percentage of patients who received hydroxychloroquine was much higher in the control group ( p < 0.001). Cox regression analysis suggested that CNS involvement and GC therapy were two independent risk factors for ON in SLE patients. The presence of anti-phospholipid antibodies (aPLs) was a risk factor for multiple joint necrosis (odds ratio: 6.28, p = 0.009). Conclusions ON remains a serious and irreversible complication in SLE. In addition to glucocorticoid therapy, we found that CNS system involvement was a risk factor for ON, while the administration of hydroxychloroquine was a protective factor. The clinical characteristics of multiple site ON patients were distinct from isolated femoral head necrosis patients. The presence of aPLs was a risk factor for multiple site osteonecrosis.

Studies on peroxynitrite-modified H1 histone: Implications in systemic lupus erythematosus

Biochimie ◽  
2014 ◽  
Vol 97 ◽  
pp. 104-113 ◽  
Author(s):  
M. Asad Khan ◽  
Kiran Dixit ◽  
Moinuddin ◽  
Zarina Arif ◽  
Khursheed Alam
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
H1 Histone

Prediction of Joint Rain Attenuation Statistics Induced on Earth–Satellite Multiple Site Diversity Systems Using Gaussian Copula

2017 ◽  
Vol 16 ◽  
pp. 95-98 ◽  
Author(s):  
Arsim Kelmendi ◽  
Charilaos Kourogiorgas ◽  
Andrej Hrovat ◽  
Athanasios D. Panagopoulos ◽  
Gorazd Kandus ◽  
...  
Keyword(s):  
Earth Satellite ◽  
Rain Attenuation ◽  
Gaussian Copula ◽  
Multiple Site ◽  
Diversity Systems ◽  
Site Diversity

Bringing Them in: The Experiences of Imported and Overseas-Qualified Teachers

2009 ◽  
Vol 53 (2) ◽  
pp. 192-206 ◽  
Author(s):  
Elaine Sharplin
Keyword(s):  
Cultural Adaptation ◽  
Multiple Site ◽  
Application Process ◽  
Empirical Examination ◽  
Teacher Shortages ◽  
Behaviour Management ◽  
Qualified Teachers ◽  
School Based ◽  
Western Australian

This qualitative multiple-site case study explores the experiences of imported and overseas-qualified teachers appointed to fill ‘difficult-to-staff’ Western Australian rural schools. In a climate of global teacher shortages, investigation of the strategies adopted to solve this problem requires empirical examination. The study of six imported and overseas-qualified teachers found that they experienced difficulties with the employment application process, were not adequately inducted into the system and experienced difficulties with cultural adaptation related to pedagogy, behaviour management and language. These teachers still remained in schools for lengths of time comparable to their Australian-born counterparts. Transitions into schools could be assisted with improved appointment processes, induction and school-based support. A research agenda for further investigation of this field is recommended.

Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex

2002 ◽  
Vol 140 (1-3) ◽  
pp. 254-267 ◽  
Author(s):  
Birthe Fahrenkrog ◽  
Bohumil Maco ◽  
Ammon M. Fager ◽  
Joachim Köser ◽  
Ursula Sauder ◽  
...  
Keyword(s):  
Nuclear Pore Complex ◽  
Nuclear Pore ◽  
Multiple Site ◽  
Specific Antibodies ◽  
Domain Specific
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